Abstract: The invention provides a wear-resistant steel plate, which has the following chemical composition (wt. %): C: 0.08-0.21%, Si: 0.15-0.45%, Mn: 1.10-1.80%, P: ?0.015%, S: ?0.010%, Nb: 0.010-0.040%, Al: 0.010-0.080%, B: 0.0006-0.0014%, Ti: 0.005-0.050%, Ca: 0.0010-0.0080%, V?0.080%, Cr?0.60%, N?0.0080%, O?0.0060%, H?0.0004%, wherein 0.025%?Nb+Ti?0.080%, 0.030%?Al+Ti?0.12%, and the balance being Fe and unavoidable impurities. The invention also provides a method of manufacturing the wear-resistant steel plate, comprising smelting, casting, rolling, post-rolling direct cooling, inter alia. The wear-resistant steel plate obtained from the above composition and process has perfect weldability, high strength, high hardness, good low-temperature toughness, and excellent machinability, and is suitable for quick-wear devices in engineering and mining machinery, such as bucket, mining vehicle body and scraper transporter, etc.