Abstract: A daisy chain two-wire sensor measurement system includes one or more slave modules, a master module and a daisy chain wire. The one or more slave modules are connected to one or more sensors, and configured to modulate a detected sensor signal into the corresponding current signal. The master module is successively cascaded to a first slave module, an upper-stage slave module, and a lower-stage slave module in the one or more slave modules through the daisy chain wire to form a daisy chain sensor network, and interconnected with an upper computer through a communication wire. The daisy chain wire is configured to supply power and transmit the current signal obtained by the slave module through modulation, such that the master module obtains and then decodes the current signal on the daisy chain wire to obtain the corresponding sensor data. A daisy chain two-wire sensor measurement method is further provided.