Patents Assigned to Bar-llan University
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Publication number: 20200082031Abstract: A logic element includes a logic block, a supply voltage input, switchable power gates and a gate selector. The logic block implements a logic function on input data to obtain at least one output data signal. The switchable power gates transfer a supply voltage from the supply voltage input to the logic block in accordance with respective gate control signals. At least two of the power gates have different respective electrical properties. The gate selector switches on differing ones of the power gates in accordance with gate selection data.Type: ApplicationFiled: June 29, 2017Publication date: March 12, 2020Applicant: Bar-llan UniversityInventors: Itamar LEVI, Osnat KEREN, Alexander FISH
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Publication number: 20200061076Abstract: Methods of treating leukodystrophy are provided. Accordingly there is provided a method of treating leukodystrophy in a subject, the method comprising administering to the subject a therapeutically effective amount of an agent capable of up-regulating activity and/or expression of a component participating in a Sigma-1 Receptor (Sig-1R) signaling pathway. Also provided are agents and methods of up-regulating activity of Sig-1R in a cell and treating a disease that can benefit from up-regulating activity of Sig-1R. Also provided are agents and methods of modulating activity of sonic hedgehog (SHH) in a cell and treating a disease that can benefit from modulating activity of SHH.Type: ApplicationFiled: May 10, 2018Publication date: February 27, 2020Applicants: Ramot at Tel-Aviv University Ltd., Bar-llan UniversityInventors: Orna ELROY-STEIN, Hanoch SENDEROWITZ, Andrea ATZMON
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Publication number: 20190295633Abstract: A CDMR memory cell, includes a first bitcell which is used to store a current data level and a second bitcell which is used to store the complementary data level. When a read operation is performed, a comparator compares the data levels read from the two bitcells. If these two levels are not complementary, the comparator outputs an indicator. This indicator serves as an alert that a storage error has, or may have, occurred.Type: ApplicationFiled: September 19, 2017Publication date: September 26, 2019Applicant: Bar-llan UniversityInventors: Robert GITERMAN, Lior ATIAS, Adam TEMAN, Alexander FISH
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Publication number: 20190220554Abstract: A logic element includes a logic block, a clock generator, a clock assigner and at least one sampling element. The logic block implements a logic function on input data to obtain a plurality output data signals. The output data signals are sampled by respective clock signals. The clock generator generates phase-shifted clock signals from a reference clock signal. The clock assigner assigns differing ones of the phase-shifted clock signals to respective output data signals. The sampling element(s) sample the output data signals in accordance with the respective assigned phase-shifted clock signals.Type: ApplicationFiled: June 29, 2017Publication date: July 18, 2019Applicant: Bar-llan UniversityInventors: Itamar LEVI, Osnat KEREN, Alexander FISH
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Publication number: 20160120184Abstract: Nanoparticle composites comprised of a metal oxide and ions of a metallic element included within a crystal lattice of said metal oxide are disclosed. Process of preparing the nanoparticle composites per se and incorporated in or on a substrate are also disclosed. Uses of the nanoparticle composites and of substrates incorporating same, particularly for reducing a formation of a load of a microorganism or of a biofilm, are also disclosed.Type: ApplicationFiled: May 5, 2014Publication date: May 5, 2016Applicant: Bar-llan UniversityInventors: Aharon GEDANKEN, Ehud BANIN, Ilana PERELSHTEIN, Rachel LUBART, Anat LIPOVSKY, Eyal MALKA, Nitzan YESHAYAHU, Nina PERKAS, Yakov SHALOM, Jonathan LELLOUCHE, Tal PATICK, Michal ESHED, Livnat NAPARSTEK
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Patent number: 9073990Abstract: An isolated pore-forming polypeptide is disclosed which comprises a naturally-occurring plugging module and a naturally-occurring pore domain, wherein at least one amino acid of the pore-forming polypeptide is mutated to generate a protease cleavage site, serving to at least partially remove the plugging module from the pore domain. The pore forming polypeptides may be inserted into an encapsulating particle and positioned such that it is capable of forming a pore through the lipid layer of the particle in a presence of the protease.Type: GrantFiled: April 4, 2011Date of Patent: July 7, 2015Assignee: Bar-llan UniversityInventors: Yoav Paas, Ilya Pittel, Uri Nir, Barak Ben-David
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Publication number: 20130184347Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.Type: ApplicationFiled: September 22, 2011Publication date: July 18, 2013Applicants: Ramot at Tel-Aviv University Ltd., BioLineRX Ltd., Bar-llan UniversityInventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul
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Publication number: 20130121915Abstract: An isolated pore-forming polypeptide is disclosed which comprises a naturally-occurring plugging module and a naturally-occurring pore domain, wherein at least one amino acid of the pore-forming polypeptide is mutated to generate a protease cleavage site, serving to at least partially remove the plugging module from the pore domain. The pore forming polypeptides may be inserted into an encapsulating particle and positioned such that it is capable of forming a pore through the lipid layer of the particle in a presence of the protease.Type: ApplicationFiled: April 4, 2011Publication date: May 16, 2013Applicant: Bar-llan UniversityInventors: Yoav Paas, Ilya Pittel, Uri Nir, Barak Ben-David
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Publication number: 20120027809Abstract: The present invention provides pharmaceutical compositions comprising water-soluble sulfonate-protected nanoparticles, more particularly, pharmaceutical compositions comprising water-soluble sulfonate-protected silver or gold nanoparticles. The pharmaceutical compositions of the invention are useful in prevention or treatment of infections or conditions or disorders caused by microorganisms capable of binding to heparan sulfate, e.g., herpes simplex viruses.Type: ApplicationFiled: June 21, 2011Publication date: February 2, 2012Applicant: Bar-llan UniversityInventors: Ronit Sarid, Aharon Gedanken, Dana Baram-Pinto
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Publication number: 20110189721Abstract: An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location.Type: ApplicationFiled: February 2, 2011Publication date: August 4, 2011Applicant: Bar-llan UniversityInventor: Mordechai DEUTSCH
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Publication number: 20090298814Abstract: Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions.Type: ApplicationFiled: June 7, 2006Publication date: December 3, 2009Applicants: RAMOT AT TEL AVIV UNIVERISTY LTD, BAR-LLAN UNIVERSITY, BIOLINERX LTDInventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Shlomit Halachmi, Eran J. Benjamin
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Patent number: 7385051Abstract: The invention relates to fluorescent N2,N3-etheno-purine (2?-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quantitation of genetic material.Type: GrantFiled: January 24, 2006Date of Patent: June 10, 2008Assignee: Bar-llan UniversityInventors: Bilha Fischer, Einat Sharon
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Publication number: 20040110698Abstract: A small interfering duplex oligonucleotide comprising a 15 to 30 base pair sequence being at least 90 % identical to a contiguous nucleic acid sequence of COX-II, as determined using the GCG BestFit software of the Wisconsin sequence analysis package, utilizing the Smith and Waterman algorithm, where gap weight equals 50, length weight equals 3, average match equals 10 and average mismatch equals −9.Type: ApplicationFiled: December 10, 2002Publication date: June 10, 2004Applicants: Kimron Veterinary Institute, Bar-llan UniversityInventors: Mordechai Shemesh, Laurence Shore, Yehuda Stram, Shulamit Michaeli, Haim Breitbart