Abstract: An adjustable interface device for connecting two components of a medical device includes an elongate body and an elongate member. The elongate body has a first end, a second end, an interior channel, and a side wall that surrounds the interior channel. The side wall defines a first connector portion adjacent the second end. The first connector portion attaches to a respective one of the components of the medical device. The elongate member has a head end portion and a shaft portion that longitudinally extends from the head end portion. The shaft portion is located at least partially in the interior channel of the elongate body. The shaft portion is configured to slidably move axially along the longitudinal axis to adjust a length of the adjustable interface device. The head end portion defines a second connector portion that attaches to another of the components of the medical device.

Abstract: The present disclosure relates to ultrasonic catheters including vibration wires that are positionable in a retracted position and an extended position, and their methods of use. In operation, catheters according to the present disclosure are operable in an occlusion crossing mode, in which the catheter emits ultrasonic energy with the vibration wires in the retracted position and in an atherectomy mode, in which the catheter emits ultrasonic energy with the vibration wires in the extended position, causing the vibration wires to oscillate. The vibration wires may directly or indirectly engage plaque within an artery, causing the plaque to break free from the artery wall. The oscillation of the vibration wires may be less abrasive than conventional cutting elements used in atherectomy procedures, such that catheters according to the present disclosure may cause less trauma to artery walls as compared to conventional atherectomy devices.

Abstract: A vascular device insertion system includes a support catheter having a hub, a flexible elongate member that extends distally from the hub, and a catheter lumen that extends through the hub and the flexible elongate member. An insertion module housing is configured to contain a motor having a hollow motor shaft. The hollow motor shaft has a proximal end, a distal end, a distal end portion, and an elongate opening that extends from the proximal end to the distal end. The distal end portion of the hollow motor shaft is configured to couple to the hub of the support catheter. The elongate opening of the hollow motor shaft and the catheter lumen of the support catheter together define a continuous passage. A motor controller is electrically coupled to the motor, and is configured to rotationally oscillate the hollow motor shaft to in turn rotationally oscillate the support catheter.

Abstract: A thrombectomy device for removing a material from a subject includes a catheter, a diaphragm, and a vacuum. The catheter includes an outer body defining a lumen extending therethrough. The diaphragm is coupled to the catheter and is moveable between an open diaphragm configuration and a closed diaphragm configuration. The diaphragm allows movement of the material through the lumen when in the open diaphragm configuration and prevents movement of the material through the lumen when in the closed diaphragm configuration. The vacuum is in communication with the lumen and is operable to exert a vacuum pressure on the diaphragm. The vacuum pressure is operable to move the diaphragm from the open diaphragm configuration to the closed diaphragm configuration.

Abstract: Embodiments herein are directed to an occlusion device that includes a body, a pair of lobes, and an adjustment assembly. One of the pair of lobes positioned at a distal portion of the body and the other one is positioned at a proximal portion. The body includes an adjustment assembly positioned between the distal and the proximal portions to change a distance between the pair of lobes. The adjustment assembly includes a receiving member and an elongated member. The elongated member is configured to move the body between an extended position and a retracted position, such that in the retracted position, the elongated member is received within an inner diameter of the receiving member. In the extended position, the elongated member is extended away from a first end of the receiving member such that the distance between the pair of lobes is increased.

Abstract: A damping assembly for a core wire of an ultrasonic catheter assembly includes a body for receiving the core wire. The body includes a bore extending from a proximal end of the body. The bore is defined by an interior surface of the body and includes an insertion region at the proximal end and a compression region disposed distal to the insertion region. A plurality of compression members are disposed within the compression region of the bore. A retention member extends at least partially into the compression region to axially compress the plurality of compression members. The interior surface of the body defining the insertion region of the bore corresponds in shape to at least a portion of an exterior surface of the retention member to facilitate insertion of the retention member into the bore.

Abstract: Disclosed herein is a catheter defining a first lumen and a second lumen. A proximal portion of the catheter can be configured to separate along a longitudinal axis to allow a proximal portion of the first lumen to be trimmed to a different length than a proximal portion of the second lumen. The catheter can include a septum disposed laterally between the first lumen and the second lumen configured to facilitate separation of the first lumen from the second lumen. The septum can include grooves, perforations, and can be formed of different materials to facilitate separation. Further the septum can include a wire configured to facilitate separation of the first lumen from the second lumen. Separation and/or trimming of the lumens positions the subcutaneous access ports in a spaced apart relationship to differentiate between infusion and aspiration lumens of the catheter.

Abstract: An implantable device for treating hypervolemia includes an expandable chamber, a rigid chamber coupled to the expandable chamber, a first valve in fluid communication with both the expandable chamber and the rigid chamber, a second valve in fluid communication with the rigid chamber and an exterior of the implantable device, and an osmotic fluid. The expandable chamber includes a first semipermeable membrane. The rigid chamber includes a piston. The first valve has an open position to permit fluid flow between the expandable chamber and the rigid chamber. The second valve has an open position to permit fluid flow from the rigid chamber to the exterior of the implantable device. The osmotic fluid has a higher osmotic concentration than bodily fluid. The osmotic fluid is designed to absorb water from the bodily fluid through the first semipermeable membrane.

Abstract: A drainage system includes a fluid-receiving container that includes an inlet and a drainage conduit communicatively coupled to the inlet of the fluid-receiving container. A first one-way valve is along the drainage conduit that provides a one-way fluid flow direction through the drainage conduit into the fluid-receiving volume. A displacement body is out-of-line with the drainage conduit and fluidly connected to the drainage conduit. The displacement body is configured to be actuated and released to provide a negative pressure to a fluid-receiving passageway through the drainage conduit. Actuation of the displacement body displaces air within the fluid-receiving passageway, the air being forced into the fluid-receiving volume by a second one-way valve and inhibited from escaping the fluid-receiving volume by the first one-way valve.

Abstract: Delivery devices, as well as systems incorporating the same and methods of using the same are disclosed. A needle assembly includes a hub having first and second input ports and an auxiliary port, and an injection needle assembly. The injection needle assembly includes an elongate hollow stylet extending distally from the hub that includes an outer side wall defining an outer lumen fluidly coupled to the auxiliary port, a first inner side wall defining a middle lumen disposed within the outer lumen that is fluidly coupled to the first input port, a second inner side wall defining an inner lumen disposed within the middle lumen that is fluidly coupled to the second input port, and a mixing chamber fluidly coupled to the outer lumen, the middle lumen, and the inner lumen.

Abstract: A vascular occlusion device includes a plurality of radially-extending segments and a plurality of angled bends connecting ends of two or more radially-extending segments of the plurality of radially-extending segments. Each angled bend may define a contact point configured to anchor to a vessel wall. The vascular occlusion device may be configurable between an unexpanded state and an expanded state, and when the vascular occlusion device is in the expanded state, the plurality of angled bends expand such that the contact points contact the vessel wall. The contact points may define a width of the vascular occlusion device in a direction perpendicular to a length of the vascular occlusion device. The width may be configured to correspond to a diameter of a blood vessel.

Abstract: A marker delivery assembly for a biopsy device includes an integration module and a marker delivery module. The integration module includes a connector defining a cavity and a neck that extends outwardly from the cavity in a longitudinal direction. A transmission cover having a shaft is disposed about the neck, and further includes a spindle gear and a drum gear. A bevel drum is rotatably coupled to the drum gear and a pushrod is engaged to the bevel drum. The marker delivery module includes a marker housing releasably coupled to the integration module. A marker delivery cartridge engages the marker housing, and is rotatable between an initial position and a delivery position. The pushrod extends through the marker delivery cartridge and forces at least one marker into the biopsy device.

Abstract: A catheter (100) for treating hypervolemia in a patient includes a luminal ingress (112) joined to a luminal egress (114) at a distal end portion (116) of the catheter having a closed distal end (102). The distal end portion is configured to at least temporarily reside within a vessel of the patient, the distal end portion including a semipermeable membrane. The luminal ingress is designed to convey an influent having a first osmotic concentration to the distal end portion. The semipermeable membrane is configured to pass blood-borne water from the vessel into the distal portion. The blood-borne water is absorbed by the influent to produce an effluent having a second osmotic concentration lower than the first osmotic concentration. Systems (200) with the catheter and methods for treating hypervolemia are also disclosed.

Abstract: A fluid connector system configured to couple a first fluid line structure, e.g. port, with a second fluid line structure, e.g. catheter. The connector system can include a connector body and one or more locking mechanisms designed to transition between an unlocked position and a locked position. The locking mechanism includes a first lever arm rotatably coupled to the connector body, and a second lever arm rotatably coupled to the first lever arm. The second lever arm can further be rotatably and releasably coupled to the port. Rotating the first lever arm uses mechanical advantage to urge the port to engage a catheter ensuring a tight seal therebetween even under high fluid pressures.

Abstract: A biopsy device having an elongate biopsy needle and a thermal cooling device. The biopsy device includes an elongate biopsy needle that has a proximal end portion, an intermediate portion, and a distal end portion. The elongate biopsy needle is made of a thermally conductive material. The biopsy device includes a thermally conductive mechanical member that extends between the proximal end portion of the elongate biopsy needle and the thermal cooling device. The thermally conductive mechanical member has a first end and a second end. The biopsy device includes a first thermo-mechanical coupler that connects the first end of the thermally conductive mechanical member to the thermal cooling device and a second thermo-mechanical coupler that connects the second end of the thermally conductive mechanical member to the proximal end portion of the elongate biopsy needle.

Abstract: Systems and methods to use an adaptor component for a particulate material delivery assembly to deliver a mixed particulate solution to a patient, the adaptor component including at least a pair of device connector ports. Each device connector port is configured to connect to a corresponding delivery line connector of a particulate delivery device to receive the mixed particulate solution. The adaptor component further includes a guidewire connector port configured to connect to a containment bag unit, the containment bag unit including a guidewire disposed therein and a catheter connector port configured to connect to a microcatheter to deliver the mixed particulate solution to the patient. The guidewire is configured to retract into and extend from the containment bag unit to position the microcatheter within the patient without disconnecting at least one of the pair of device connector ports from the delivery line connector of the particulate delivery device.

Abstract: A lipid emulsion is provided herein, including sunflower lecithin, an oil, a co-surfactant, and a cryogenic agent. Also provided is a method of preparing a lipid emulsion, the method including: (i) dissolving sunflower lecithin in water to create an aqueous phase; (ii) mixing an oil, a co-surfactant and a cryogenic agent to create an organic phase; and (iii) homogenizing the aqueous and organic phases to produce the lipid emulsion, wherein the lipid emulsion has a mean particle size of less than about 1000 nm.

Abstract: Embodiments herein are directed to a measurement device. The measurement device includes a processing device, a catheter, and a tip portion. The tip portion is disposed at a distal end of the catheter. The tip portion receives the distal end of the catheter. A diaphragm film assembly is coupled to the tip portion at an opposite end that receives the distal end of the catheter. The diaphragm film assembly is configured to flexibly move between a plurality of positions based on an applied pressure that displaces the diaphragm film assembly. A sensor assembly communicatively coupled to the processing device, the sensor assembly is configured to measure the applied pressure displacing the diaphragm film assembly and the processing device determines a concentration of ammonia currently in a fluid at the tip portion.

Abstract: The present disclosure is generally directed to novel bead geometries that can provide improved sanding efficiencies in rotational atherectomy procedures. The abrasive elements disclosed herein may open stenotic lesions to diameters that are substantially larger than the maximum diameter of the abrasive element. In some embodiments, the abrasive elements may open stenotic lesions to diameters that are substantially larger than the maximum diameter of the sheath from which the abrasive element is delivered through. In some embodiments the abrasive elements are configured to expand when the abrasive elements are rotated at high speeds. In some embodiments, the abrasive elements have local centers of mass that are positioned at opposite diagonal ends. Accordingly, the abrasive elements disclosed herein may have improved sanding ranges, reduce treatment times, and prevent re-stenosis.

Abstract: An apparatus is for forming a balloon layer, such as on an expanded base balloon. The apparatus includes a mandrel supporting the expanded base balloon. At least one gripper is provided for gripping the balloon layer, and an actuator is for stretching the balloon layer over the expanded base balloon, such as by moving the at least one gripper. Related methods for forming a balloon layer are also disclosed.