Patents Assigned to Base Pair Biotechnologies, Inc.
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Patent number: 11725240Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid derivatives.Type: GrantFiled: January 19, 2021Date of Patent: August 15, 2023Assignee: BASE PAIR BIOTECHNOLOGIES, INC.Inventors: Jasmine Kaur, Rafal Drabek, George W. Jackson, Robert Batchelor, Alexander Chiu
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Patent number: 11608356Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as antibiotics, such as colistin.Type: GrantFiled: February 22, 2020Date of Patent: March 21, 2023Assignee: BASE PAIR BIOTECHNOLOGIES, INC.Inventors: Robert Batchelor, George W. Jackson, Truong Nguyen, Vinoth Sankarapani
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Patent number: 11427825Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as drug compounds, such as levamisole and cocaine.Type: GrantFiled: February 28, 2018Date of Patent: August 30, 2022Assignee: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Robert Batchelor, Truong Nguyen, Rafal Drabek, Alexander S. Chiu, Deepak Thirunavukarasu, Vinoth Sankarapani
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Patent number: 11111603Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.Type: GrantFiled: January 30, 2019Date of Patent: September 7, 2021Assignee: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Robert Batchelor, Alexander S. Chiu, Rafal Drabek, Deepak Thirunavukarasu, Caitlin Bruns
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Patent number: 11078489Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.Type: GrantFiled: April 23, 2018Date of Patent: August 3, 2021Assignee: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Darryl Bornhop
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Patent number: 10941444Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as lipoarabinomannan (LAM).Type: GrantFiled: January 30, 2019Date of Patent: March 9, 2021Assignee: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Robert Batchelor, Rafal Drabek, Caitlin Bruns
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Patent number: 10927381Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as molecules used proteins or peptides, such as LL37.Type: GrantFiled: November 7, 2019Date of Patent: February 23, 2021Assignee: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Robert Batchelor, Truong Nguyen, Victoria Singer, Garam Lee, Rafal Drabek
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Patent number: 10920228Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as biocide molecules.Type: GrantFiled: January 30, 2019Date of Patent: February 16, 2021Assignee: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Robert Batchelor, Alexander S. Chiu, Rafal Drabek, Deepak Thirunavukarasu
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Patent number: 10676781Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as tetrahydrocannabinol (THC).Type: GrantFiled: June 12, 2018Date of Patent: June 9, 2020Assignee: Base Pair Biotechnologies, Inc.Inventor: George W. Jackson
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Patent number: 10538770Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as chikungunya viral proteins, such as chikungunya envelope protein E1.Type: GrantFiled: September 21, 2017Date of Patent: January 21, 2020Assignee: Base Pair Biotechnologies, Inc.Inventor: George W. Jackson
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Patent number: 10415041Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as amino acids, such as citrulline, and to target molecules such as crystallin or its subunits, such as alpha crystallin B-chain (CRYAB).Type: GrantFiled: February 9, 2018Date of Patent: September 17, 2019Assignee: Base Pair Biotechnologies, Inc.Inventor: George W. Jackson
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Patent number: 10059951Abstract: This invention relates to functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, more particularly to functional ligands with binding affinity to metabolites of nerve agents, and further particularly to functional ligands with binding affinity to metabolites of VX-acid (metabolite of VX nerve agent) and GB-acid (metabolite of sarin nerve agent).Type: GrantFiled: February 17, 2017Date of Patent: August 28, 2018Assignee: Base Pair Biotechnologies, Inc.Inventor: George W. Jackson
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Patent number: 9963706Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.Type: GrantFiled: March 9, 2016Date of Patent: May 8, 2018Assignee: Base Pair Biotechnologies, Inc.Inventors: George W Jackson, Darryl Bornhop
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Patent number: 9035034Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.Type: GrantFiled: January 23, 2013Date of Patent: May 19, 2015Assignee: Base Pair Biotechnologies, Inc.Inventor: George W. Jackson
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Publication number: 20140315727Abstract: Molecular probes to particular targets may be nucleic acids that may generally possess resistance to degradation when bound to a target molecule. For example, the molecular probes may be generally resistant to nuclease degradation when bound to their target molecules, and generally not resistant to nuclease degradation when unbound to their target molecules. This may be utilized, for example, to selectively degrade unbound molecular probes while preserving the bound molecular probes, which may thus serve as an indication of the presence of their target molecules in a sample.Type: ApplicationFiled: April 21, 2014Publication date: October 23, 2014Applicant: Base Pair Biotechnologies, Inc.Inventors: George W. Jackson, Mark Morris
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Publication number: 20130245243Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.Type: ApplicationFiled: January 23, 2013Publication date: September 19, 2013Applicant: Base Pair Biotechnologies, Inc.Inventor: George W. Jackson
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Publication number: 20130157871Abstract: The present invention relates to methods for generating functional biomolecules. In one exemplary aspect of the invention, generation of functional biomolecules may be performed against multiple targets simultaneously within a single system. In general, a plurality of targets may be disposed within in a single reaction volume and a library of biomolecules, such as a nucleic acid library, may be applied to the reaction volume. The members of the library that do not bind to any of the plurality of targets under given conditions may then be partitioned. The remaining members of the library may then be marked and/or tagged, such as to identify the particular target or targets to which the member of the library binds. The binding members of the library may then be isolated and, by virtue of the marking or tagging, be matched to a particular target or targets.Type: ApplicationFiled: October 15, 2012Publication date: June 20, 2013Applicant: BASE PAIR BIOTECHNOLOGIES, INC.Inventor: BASE PAIR BIOTECHNOLOGIES, INC.
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Patent number: 8314052Abstract: The present invention relates to methods for generating functional biomolecules. In one exemplary aspect of the invention, generation of functional biomolecules may be performed against multiple targets simultaneously within a single system. In general, a plurality of targets may be disposed within in a single reaction volume and a library of biomolecules, such as a nucleic acid library, may be applied to the reaction volume. The members of the library that do not bind to any of the plurality of targets under given conditions may then be partitioned. The remaining members of the library may then be marked and/or tagged, such as to identify the particular target or targets to which the member of the library binds. The binding members of the library may then be isolated and, by virtue of the marking or tagging, be matched to a particular target or targets.Type: GrantFiled: January 7, 2010Date of Patent: November 20, 2012Assignee: Base Pair Biotechnologies, Inc.Inventor: George Jackson