Abstract: The present invention relates to a process for preparing 3-phenyl(thio)uracils and -dithiouracils of the formula I where the variables are each as defined in the description, and also intermediates for their preparation.
Type:
Application
Filed:
March 4, 2011
Publication date:
June 23, 2011
Applicant:
BASF Aktiengesselschaft
Inventors:
Sandra Löhr, Joachim Gebhardt, Guido Mayer, Michael Keil, Thomas Schmidt, Bernd Wolf
Abstract: This invention relates to a newly identified protein useful for treating diseases of the immune system, methods for obtaining said protein, isolated nucleic acids encoding said protein, and methods for obtaining inhibitors of said protein. The protein of this invention is characterized by an apparent molecular weight of about 32 kD, an isoelectric point of about 4.0-4.5 and coprecipitation with CD45. The protein may also be used in in vitro or in vivo assays to identify inhibitors of T cell activation.
Type:
Grant
Filed:
April 22, 1996
Date of Patent:
December 8, 1998
Assignee:
BASF Aktiengesselschaft
Inventors:
Stefan Meuer, Burkhart Schraven, David Schoenhaut, Sheldon Ratnofsky