Patent number: 6225313
Abstract: Substituted 2-phenyl-3(2H)-pyridazinones I
and salts thereof, where
n=0, 1, 2; R1=C1-C4-alkyl, C1-C4-haloalkyl;
R2=H, halogen; R3=halogen, CN;
R4=H, NO2, CN, CHO, NH—OH, C1-C4-alkyl, C1-C4-halogenalkyl, —OR5, —CH═N—OR6, —CH═C(R7)—CO—OR8, —CO—OR9, C1-C6-alkyl-SO2—NH, di(C1-C6-alkylsulfonyl)amino or
R5=C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, (C1-C6-alkoxy)carbonyl-C1-C4-alkyl, (C3-C6-alkenyloxy)carbonyl-C1-C4-alkyl, (C3-C6-alkynyloxy)carbonyl-C1-C4-alkyl, C1-C4-alkoxy(C1-C4-alkoxy)carbonyl-C1-C4-alkyl;
R6=H, C1-C4-alkyl, hydroxycarbonyl-C1-C4-alkyl, (C1-C4-alkoxy)carbonyl-C1-C4-alkyl;
R7=H, halogen, C1-C4-alkyl; R8=H, C1-C6-alkyl;
R9=H, C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, C1-C4-alkoxy-C1-C4-alkoxy, hydroxycarbonyl-C1-C4-alkyl, (C1-C6-alkoxy)carbonyl-C1-C4-alkyl, (C3-C6-alkenyloxy)carbonyl-C1-C4-alkyl, (C3-C6-alkynyloxy)car
Type:
Grant
Filed:
March 16, 2000
Date of Patent:
May 1, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter Schäfer, Gerhard Hamprecht, Markus Menges, Olaf Menke, Michael Rack, Robert Reinhard, Cyrill Zagar, Peter Münster, Karl-Otto Westphalen, Martina Otten, Helmut Walter
Patent number: 6222034
Abstract: A 3-substituted 3,4,5,6,7,8-hexahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine compound of formula I
wherein
R1 is hydrogen, C1-C4-alkyl, acetyl or benzoyl, optionally substituted phenyl-C1-C4-alkyl, naphthyl-C1-C3-alkyl, phenyl-C2-C3-alkanone or a phenylcarbamoyl-C2-alkyl,
R2 is optionally substituted phenyl, pyridyl, pyrimidyl or pyrazinyl, or an optionally substituted bicyclus wherein one of the two fused rings is a phenyl, a pyridyl, a pyrimidyl or a pyrazinyl ring,
A is NH or oxygen,
B is hydrogen or methyl,
C is hydrogen, methyl or hydroxyl,
X is nitrogen,
Y is CH2, CH2—C2, CH2—C2—CH2 or CH2—CH,
Z is nitrogen, C or CH, and the linkage between Y and Z is a single or a double bond, and
n is 2, 3 or 4,
or a physiologically tolerated salt thereof, and compositions comprising them and their use as antagonists of 5HT1B and 5HT1A and for the treatment of depression and related disorders.
Type:
Grant
Filed:
March 10, 1999
Date of Patent:
April 24, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Gerd Steiner, Wilfried Lubisch, Alfred Bach, Franz Emling, Karsten Wicke, Hans-Jürgen Teschendorf, Berthold Behl, Sharon Cheetham, Frank Kerrrigan