Abstract: The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula wherein R1 signifies hydrogen or an amino protecting group; Z signifies hydrogen or an amino protecting group; and * represents a center of chirality. 3-Amino-pyrrolidine derivatives, especially optically active 3-amino-pyrrolidine derivatives, are intermediates for the production of agrochemicals and of pharmaceutically active substances such as, for example, of vinylpyrrolidinone-cephalosporin derivatives.
Type:
Grant
Filed:
July 29, 2003
Date of Patent:
March 29, 2005
Assignee:
Basilea Pharmaceutica AG, A Swiss Company
Abstract: Azole derivatives of the formula I
wherein
R14, R15 are each independently hydrogen or fluorine,
T is a group of the formula:
wherein
R9 is pyrrolidinyl or a group A—NH—B—,
A is hydrogen or straight-chain or branched C1-C5 alkyl;
B is straight-chain or branched C1-C4 alkylene, —CH2—CONH—CH2 or —CH2CH2CH2—CH(NH2); and
X− is a pharmaceutically acceptable anion;
and pharmaceutically acceptable salts of said compounds, and hydrates and solvates of the compounds of formula I and the salts thereof can be used in the production of medicaments for treating fungal infections and mycoses.
Type:
Grant
Filed:
March 5, 1999
Date of Patent:
October 9, 2001
Assignee:
Basilea Pharmaceutica AG, a Swiss Company