Abstract: Disclosed is a syringe disposal device (10) suitable for disposal of a single syringe. The device is suitable for disposal of syringes (30) having a needle (33), a barrel (38), a plunger (39) and on the barrel (38) or plunger (39), a transversely extending flange portion (38a). The disposal device (10) may include a needle encapsulating portion (12), a syringe barrel encapsulating portion (14) and a syringe retention portion (16). The syringe retention portion (16) has an open end (18) to allow syringe (30) to be inserted into device (10). The opposed end (19) of syringe retention portion (16) communicates the retention portion (16) with syringe barrel encapsulating portion (14). Engagement means (20) are provided at, or proximate, the opposed end (19) of the syringe retention portion (16) for retaining syringe (30) within the disposed device (10) after passage of the transversely extending flange (38a) past the engagement means (20) by interference fit.