Patents Assigned to Battelle Memorial Institute
  • DIRECT DETERMINATION OF ANTIBODY CHAIN PAIRING
    Publication number: 20200251318
    Abstract: Methods are described for using a combination of mass spectroscopic and proteomic approaches for identifying the specific pairing of heavy and light chains for an intact antibody, an antibody fragment, a mixture of intact antibodies, or a mixture of antibody fragments.
    Type: Application
    Filed: February 5, 2020
    Publication date: August 6, 2020
    Applicant: Battelle Memorial Institute
    Inventor: Jared B. Shaw
  • High capacity and stable cathode materials
    Patent number: 10734641
    Abstract: High energy density cathode materials, such as LiNixMnyCozO2 (NMC) cathode materials, with improved discharge capacity (hence energy density) and enhanced cycle life are described. A solid electrolyte, such as lithium phosphate infused inside of secondary particles of the cathode material demonstrates significantly enhanced structural integrity without significant or without any observable particle cracking occurring during charge/discharge processes, showing high capacity retention of more than 90% after 200 cycles at room temperature. In certain embodiments the disclosed cathode materials (and cathodes made therefrom) are formed using nickel-rich NMC and/or are used in a battery system with a non-aqueous dual-Li salt electrolytes.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: August 4, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Jianming Zheng, Jiguang Zhang, Pengfei Yan, Chongmin Wang, Wengao Zhao, Shuru Chen, Wu Xu
  • Chromatin activity precipitation method and system
    Patent number: 10731202
    Abstract: Methods and systems for identifying binding sites in macromolecules using small molecule mimics of naturally occurring molecules is disclosed. A reactive probe is provided that mimics small molecule cofactors. A target macromolecule is irreversibly bound to the probe in vivo to selectively pull down or precipitate probe-bound macromolecules. The macromolecules may be, but are not limited to, DNA, RNA, and proteins.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: August 4, 2020
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Stephen R. Lindemann, Aaron T. Wright
  • Methods and compositions for preparing triglycerides containing fatty acid vicinal diester functionality
    Patent number: 10731105
    Abstract: A method for producing a triglyceride including fatty acids with vicinal diesters: (a) providing a triglyceride including fatty acids with epoxide groups; (b) reacting the epoxide groups with carboxylic acid salts under basic conditions to produce a triglyceride including fatty acids with vicinal ester/alkoxides; (c) protonating the vicinal ester/alkoxides to produce a triglyceride including fatty acids with vicinal ester/alcohols; and (d) reacting the vicinal ester/alcohols with carboxylic acids under acidic conditions to produce a triglyceride including fatty acids with vicinal diesters.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: August 4, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Herman P. Benecke, Daniel B. Garbark
  • RISK-INFORMED AUTONOMOUS ADAPTIVE CYBER CONTROLLERS
    Publication number: 20200244691
    Abstract: Technology related to risk-informed autonomous adaptive cyber controllers is disclosed. In one example of the disclosed technology, a method includes generating probabilities of a cyber-attack occurring along an attack surface of a network. The probabilities can be generated using sensor and operational data of a network as inputs to an attack graph. The risk scores can be determined using a plurality of fault trees and the generated probabilities from the attack graph. The respective risk scores can correspond to respective nodes of an event tree. The event tree and the determined risk scores can be used to determine risk estimates for a plurality of configurations of the network. The risk estimates for the plurality of configurations of the network can be used to reconfigure the network to reduce a risk from the cyber-attack.
    Type: Application
    Filed: June 5, 2019
    Publication date: July 30, 2020
    Applicant: Battelle Memorial Institute
    Inventors: Arun Veeramany, William James Hutton, III, Siddharth Sridhar, Sri Nikhil Gupta Gourisetti, Garill A. Coles, Mark J. Rice, Paul M. Skare, David O. Manz, Jeffery E. Dagle, Stephen D. Unwin
  • EVALUATING CYBER-RISK IN SYNCHROPHASOR SYSTEMS
    Publication number: 20200244698
    Abstract: Technology related to evaluating cyber-risk for synchrophasor systems is disclosed. In one example of the disclosed technology, a method includes generating an event tree model of a timing-attack on a synchrophasor system architecture. The event tree model can be based on locations and types of timing-attacks, an attack likelihood, vulnerabilities and detectability along a scenario path, and consequences of the timing-attack. A cyber-risk score of the synchrophasor system architecture can be determined using the event tree model. The synchrophasor system architecture can be adapted in response to the cyber-risk score.
    Type: Application
    Filed: January 29, 2019
    Publication date: July 30, 2020
    Applicant: Battelle Memorial Institute
    Inventors: Seemita Pal, Arun Veeramany, Christopher A. Bonebrake, Beverly E. Johnson, William James Hutton, III, Siddharth Sridhar, Sri Nikhil Gupta Gourisetti, Garill A. Coles
  • Two dimensional meta-material windows
    Patent number: 10725208
    Abstract: Conductive nanoshells are oriented so as to redirect incident radiation as a function of wavelength. Nanoshells can be formed on templates such as nanospheres or gratings and embedded in an elastomeric layer. In some examples, conductive nanoshells are coupled to a layer that is configured to unbuckle and buckle as a function of temperature, so that radiation in one or more wavelength ranges is directed differently at different temperatures. Building windows can include such layers to that infrared radiation is reflected on warm days and directed into a building on cool days. Such layers can also direct incident visible radiation to a room ceiling so as to enhance interior lighting.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: July 28, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Kyle J. Alvine, Bruce E. Bernacki
  • Method of evaluating change in energy consumption due to Volt VAR optimization
    Patent number: 10725075
    Abstract: A method of evaluating an optimization system is disclosed. The system is transitioned from an on state to an off state. Data is collected at time intervals for a time period before and after the system is transitioned from the on state to the off state. The transitioning occurs while a load of a particular type is active. In one embodiment, the optimization system is a Volt/VAR Optimization (VVO) system.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: July 28, 2020
    Assignees: Battelle Memorial Institute, American Electric Power Company, Inc.
    Inventors: Tess L. Williams, Kevin P. Schneider, Michael T. Campbell, Derek S. Lewellen
  • System and method for solution constituent and concentration identification
    Patent number: 10724968
    Abstract: A system and method are disclosed for determining a constituent and/or concentration of a solid dissolved in a liquid. In one embodiment, a method is provided to interrogate and identify a liquid in a medical container.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: July 28, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Wesley C. Pirkle, Richard L. Shoaf
  • Prostate cancer-associated secreted proteins
    Patent number: 10725053
    Abstract: Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate cancer-related molecules in a sample obtained from a subject, including the prostate cancer-related molecules AGR2, AGR3, CRISP3, CCL3, CEACAM5, CEACAM6, IL24, MMP9, CXCL14, CD90, POSTN, and SFRP4. The methods can include administering at therapy to a subject with prostate cancer. Methods are provided for treating a subject with intermediate- or high-risk prostate cancer, which can include measuring increased expression of MMP9 in a sample obtained from a subject compared to a control representing expression of MMP9 expected in a sample from a subject who has low-risk prostate cancer.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: July 28, 2020
    Assignees: Battelle Memorial Institute, University of Washington
    Inventors: Wei-Jun Qian, Tujin Shi, Alvin Y. Liu
  • Capture and release of acid gasses using tunable organic solvents with aminopyridine
    Patent number: 10722837
    Abstract: A class of water lean, organic solvents that can bind with various acid gasses to form acid gas bound molecules having a high degree of intramolecular hydrogen bonding which enables their use as regenerable solvents for acid gas capture. Unlike the other devices described in the prior art, the present invention takes advantage of shortened distances between the portions of the molecule that form hydrogen bonds within the structures when loaded with an acid gas so as to create a molecule with a higher internal bonding affinity and a reduced proclivity for agglomeration with other molecules.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: July 28, 2020
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Phillip K. Koech, Deepika Malhotra, David J. Heldebrant, Vassiliki-Alexandra Glezakou, Roger J. Rousseau, David C. Cantu
  • Wireless and power-source-free extravasation and infiltration detection sensor
    Patent number: 10722136
    Abstract: A system detects extravasation or infiltration by segregating active components that drive a passive sensor for economical single use. A receiving antenna of the passive sensor receives a transmitted signal comprising RF electromagnetic power. A first circuit transmits a first portion of the received signal through a body portion. A sensor detects a resultant signal from the body portion. A second circuit combines a reference signal comprising a second portion of the received signal with the resultant signal so as to define an output signal. A transmit antenna transmits the output signal to a receiver.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: July 28, 2020
    Assignee: Battelle Memorial Institute
    Inventor: Chad E. Bouton
  • Methods and compositions for identifying repeating sequences in nucleic acids
    Patent number: 10718016
    Abstract: Short Tandem Repeats are currently used by law enforcement and others, for example, for the identification of individuals by DNA matching. A method is described herein that uses WPD to classify and identify repeating sequences in nucleotide sequences from the position and frequency information contained within nucleotide sequences. This decomposition allows for the quick classification of nucleotide sequences (i.e., reads) into two different classes, including, for example, one class that contains sequencer reads that contain a repeat motif with non-repeat sequence on either flank, and another class that contains sequencer reads that do not contain any repeat sequence.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: July 21, 2020
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Joseph J. Regensburger, Aaron J. Sander, Jared M. Schuetter, Daniel M. Bornman, Seth A. Faith, Scott C. Nelson, Brian A. Young
  • Compositions and methods for reducing muscle contraction
    Patent number: 10702510
    Abstract: Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The methods may comprise the step of administering an oxime or pharmaceutically acceptable salt thereof to a subject in need thereof in an amount sufficient to achieve said reduced muscle contraction/neuromuscular blockade. Kits and articles of manufacture comprising a container having a label and a composition are also disclosed.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: July 7, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Brian L. Burback, Jessica Catherine Bright, Jerry D. Johnson
  • MIXING HEAD SYSTEMS AND METHODS FOR FUSED DEPOSITION MODELING
    Publication number: 20200207021
    Abstract: Disclosed are systems and methods for mixing a plurality of materials for fused deposition modeling printing. The systems and methods can both mix and extrude FDM printer filaments. The mixing can be accomplished via a mixing element rotating in a heated chamber of the extruder's hot-end in order to achieve the shear forces to induce mixing of the molten plastics. Further, the mixing element can provide a secondary driving mechanism to assist with extruding the extrudate.
    Type: Application
    Filed: December 23, 2019
    Publication date: July 2, 2020
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Josef F. Christ, Zachary C. Kennedy, Rodrigo Guerrero
  • ELECTROLYTES FOR WIDE-TEMPERATURE RANGE LITHIUM ION BATTERIES
    Publication number: 20200212486
    Abstract: Electrolytes for lithium ion batteries operable over a wide temperature range are disclosed. A lithium ion battery including a disclosed electrolyte may be operable over a temperature range of from ?50 ° C. to 60 ° C. The electrolytes include a lithium salt, a non-aqueous carbonate-based solvent, a cesium salt and/or rubidium salt as a first additive, and two or more additional additives.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 2, 2020
    Applicant: Battelle Memorial Institute
    Inventors: Wu Xu, Bin Liu
  • Solid, hydrophobic aggregators and methods of making and using the same
    Patent number: 10695745
    Abstract: Disclosed herein are aggregators that can be cellulosic particles having high oil sorption capacity, high hydrophobicity, high buoyancy in water, and an aggregation quality that can support environmental remediation of hydrocarbon spills (e.g., crude oil spills) by various cleanup strategies including burning, skimming, or bioremediation. Also disclosed are methods of making the materials and methods of using the materials for environmental remediation.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: June 30, 2020
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Yongsoon Shin, George T. Bonheyo, Eric M. Winder
  • System and process for continuous and controlled production of metal-organic frameworks and metal-organic framework composites
    Patent number: 10695741
    Abstract: A MOF production system and method of making are detailed for continuous and controlled synthesis of MOFs and MOF composites. The system can provide optimized yields of MOFs and MOF composites greater than or equal to 95%.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: June 30, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Radha Kishan Motkuri, Jagannadha R. Bontha, B. Peter McGrail
  • Flexible sheet for neuromuscular stimulation
    Patent number: 10695564
    Abstract: A flexible sheet for neurostimulation is described having a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: June 30, 2020
    Assignee: Battelle Memorial Institute
    Inventors: John Bartholomew, Jeffrey Friend
  • Functionally graded coatings and claddings
    Patent number: 10695811
    Abstract: A shear assisted extrusion process for producing cladded materials wherein a cladding material and a material to be cladded are placed in sequence with the cladded material positioned to contact a rotating scroll face first and the material to be cladded second. The two materials are fed through a shear assisted extrusion device at a preselected feed rate and impacted by a rotating scroll face to generate a cladded extrusion product. This process allows for increased through wall strength and decreases the brittleness in formed structures as compared to the prior art.
    Type: Grant
    Filed: February 17, 2018
    Date of Patent: June 30, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Vineet V. Joshi, Glenn J. Grant, Curt A. Lavender, Scott A. Whalen, Saumyadeep Jana, David Catalini, Jens T. Darsell