Patents Assigned to BAUSCH HEALTH IRELAND LIMITED
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Patent number: 11957753Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.Type: GrantFiled: April 30, 2018Date of Patent: April 16, 2024Assignee: BAUSCH HEALTH IRELAND LIMITEDInventors: Arturo Angel, Gordon Dow
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Patent number: 11872218Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.Type: GrantFiled: December 23, 2021Date of Patent: January 16, 2024Assignee: BAUSCH HEALTH IRELAND LIMITEDInventors: Gareth Winckle, Gregory T. Fieldson
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Patent number: 11839656Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.Type: GrantFiled: November 23, 2022Date of Patent: December 12, 2023Assignee: Bausch Health Ireland LimitedInventors: Arturo Angel, Gordon Dow
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Patent number: 11834521Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.Type: GrantFiled: March 30, 2023Date of Patent: December 5, 2023Assignee: Bausch Health Ireland LimitedInventors: Kunwar Shailubhai, Stephen Comiskey, Rong Feng, Juncai Bai, Ruoping Zhang, Jun Jia, Junfeng Zhou, Qiao Zhao, Guoqing Zhang
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Publication number: 20230277447Abstract: Provided herein are GI specific rifaximin release compositions which can be formulated for targeted delivery of rifaximin to one or more portions of the GI tract. Methods of treating diseases and disorders with the disclosed compositions are also provided.Type: ApplicationFiled: June 25, 2021Publication date: September 7, 2023Applicant: Bausch Health Ireland LimitedInventors: Jacob Cole, Brian R. Rohrs, Daniel J. Stein, Robert J. Israel, Ezra R. Lowe
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Patent number: 11679115Abstract: Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.Type: GrantFiled: January 21, 2021Date of Patent: June 20, 2023Assignee: Bausch Health Ireland LimitedInventors: Gordon J. Dow, Radhakrishnan Pillai, Varsha D. Bhatt
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Patent number: 11679116Abstract: Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.Type: GrantFiled: July 2, 2021Date of Patent: June 20, 2023Assignee: Bausch Health Ireland LimitedInventors: Gordon J. Dow, Radhakrishnan Pillai, Varsha D. Bhatt
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Patent number: 11654139Abstract: The present invention provides methods for treating onychomycosis. In certain embodiments, the methods comprise comprising applying a pharmaceutically acceptable formulation containing 10% efinaconazole once a day for a treatment period of at least 36 weeks to the treatment area of an onychomycosis patient (a) without debriding the nail or nail-associated tissue initially or during the treatment period and/or (b) without removing the formulation from the treatment area during the treatment period. In certain embodiments, the formulation also comprises, water, cyclomethicone, diisopropyl adipate, alcohol, C12-15 alkyl lactate, butylated hydroxytoluene, citric acid anhydrous, and disodium edetate.Type: GrantFiled: October 5, 2020Date of Patent: May 23, 2023Assignee: Bausch Health Ireland LimitedInventors: Radhakrishnan Pillai, Gordon Dow
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Publication number: 20230149389Abstract: The present disclosure is directed to the use of methylnaltrexone or a salt thereof or an ion pair thereof for reducing mortality in a subject suffering from an underlying disease or condition (e.g., advanced illness, cancer, a chronic non-cancer pain, postoperative ileus, or recovery from orthopedic surgery).Type: ApplicationFiled: October 13, 2022Publication date: May 18, 2023Applicant: Bausch Health Ireland LimitedInventor: Neal Slatkin
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Patent number: 11648256Abstract: Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.Type: GrantFiled: November 23, 2022Date of Patent: May 16, 2023Assignee: Bausch Health Ireland LimitedInventors: Gordon J. Dow, Radhakrishnan Pillai, Varsha D. Bhatt
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Publication number: 20220280478Abstract: Provided herein is the use of rifamycin SV the treatment of sickle cell disease (SCD).Type: ApplicationFiled: March 4, 2022Publication date: September 8, 2022Applicant: Bausch Health Ireland, LimitedInventors: Ezra R. Lowe, Zeev Heimanson
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Patent number: 11403386Abstract: In one implementation, a system for detecting counterfeit accessories that are consumable, disposable, or otherwise user replaceable is disclosed. The system includes a host controller, a processor, and a computer-readable storage medium that includes instructions. Upon execution by the processor, the instructions cause the system to perform operations. The operations include obtaining an identifier of an accessory, a current value of usage data for the accessory, and a usage digest of the current value from a storage device associated with the accessory. An expected usage digest is generated based on the current value, the identifier, and a host secret. The expected usage digest is compared with the usage digest and the current value with a threshold usage value. The accessory is activated with the host controller responsive to the expected usage digest being identical to the usage digest and the current value satisfying the threshold usage value.Type: GrantFiled: August 30, 2019Date of Patent: August 2, 2022Assignee: Bausch Health Ireland LimitedInventors: Richard L. Fix, Randy Holmberg
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Patent number: 11395692Abstract: Apparatus and methods for delivering coolant to an energy delivery device used to treat tissue with electromagnetic energy. A cooling system includes a pump that is configured to pump a coolant to the energy delivery device.Type: GrantFiled: August 30, 2019Date of Patent: July 26, 2022Assignee: Bausch Health Ireland LimitedInventors: Craig Robert Bockenstedt, Gregory T. Wing
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Patent number: 11389467Abstract: The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.Type: GrantFiled: July 31, 2020Date of Patent: July 19, 2022Assignee: BAUSCH HEALTH IRELAND LIMITEDInventors: Varsha Bhatt, Radhakrishnan Pillai, Arturo Angel
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Patent number: 11364198Abstract: Provided herein are compositions comprising an oil-in-water emulsion, wherein the emulsion comprises a liquid oil component; a cross-linked homopolymer based on acrylic acid and/or a cross-linked copolymer of acrylic acid and acrylic acid esters; and water. In some embodiments, the composition is a vehicle for the delivery of an active agent.Type: GrantFiled: April 5, 2019Date of Patent: June 21, 2022Assignee: BAUSCH HEALTH IRELAND LIMITEDInventors: Arturo Angel, Chandelle Hermes
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Publication number: 20220175764Abstract: The present disclosure is directed to the use of methylnaltrexone, or a salt thereof, and rifaximin for the treatment of increased gut permeability, or an associated disorder, e.g., NASH or NAFLD.Type: ApplicationFiled: November 18, 2021Publication date: June 9, 2022Applicant: Bausch Health Ireland LimitedInventors: Lorin K. Johnson, XiaoJun Nicole Deng, William J. Jo Siu, Robert J. Israel, Zeev Heimanson
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Patent number: 11324710Abstract: Topical pharmaceutical compositions for treating a skin condition or disorder are provided. The topical pharmaceutical compositions can be formulated as lotions containing a therapeutically effective amount of an active agent, such as tretinoin, a viscosity increasing agent, and advantageously small amounts of both a polymeric emulsifier and an oil component. The topical compositions of the present invention are tolerated exceptionally well by subjects to whom the compositions are administered.Type: GrantFiled: April 5, 2019Date of Patent: May 10, 2022Assignee: BAUSCH HEALTH IRELAND LIMITEDInventors: Varsha Bhatt, Radhakrishnan Pillai
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Patent number: 11319346Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.Type: GrantFiled: September 17, 2021Date of Patent: May 3, 2022Assignee: Bausch Health Ireland LimitedInventors: Kunwar Shailubhai, Stephen Comiskey, Rong Feng, Juncai Bai, Ruoping Zhang, Jun Jia, Junfeng Zhou, Qiao Zhao, Guoqing Zhang
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Publication number: 20220096461Abstract: Provided herein are pharmaceutical compositions comprising methylnaltrexone, lauryl sulfate or docusate, and at least one of an oil, a surfactant or a cosolvent, wherein the methylnaltrexone and lauryl sulfate or docusate are present as an ion pair. The pharmaceutical compositions may further comprise a surfactant so as to provide self-emulsifying methylnaltrexone delivery systems.Type: ApplicationFiled: October 6, 2021Publication date: March 31, 2022Applicant: Bausch Health Ireland LimitedInventors: Brian R. Rohrs, Daniel J. Stein, Vijay Kumar, Eric Phillips
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Patent number: D970741Type: GrantFiled: December 21, 2020Date of Patent: November 22, 2022Assignee: BAUSCH HEALTH IRELAND LIMITEDInventors: Randy Holmberg, Craig Bockenstedt, Jonathan Pittsford