Abstract: Small organic molecules capable of effecting a “pharmacological trabeculocanalotomy” in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.

Abstract: Ophthalmic compositions include a polycation material to enhance antimicrobial efficacy against bacteria such as E. coli. The compositions include eye drop and contact lens treating solutions. A preferred polycation material is cationic cellulose derivatives.

Abstract: The present invention is directed to an ophthalmic solution for soft contact lenses for controlled release of polyethers into an eye's tear film. Polyether components of the subject solution are released from the soft contact lens material matrix over long time periods to produce longer lasting wetting performance, improved lubricity, improved end-of-the-day comfort and reduced feeling of dryness from wearing contact lenses. The present invention also includes the use of cationic polyelectrolytes for controlling the swelling of hydrogel contact lenses typically caused by the absorption of high concentrations of polyethers.

Abstract: Disclosed is an improved sustained release drug delivery device and method of producing such device. The device comprises a drug core in an impermeable cup or impermeable coating layer that is adhered to an uncured suture tab and covered with a permeable polymer coating layer that is similar to the makeup of the suture tab. The permeable polymer coating layer that covers the device, covering the impermeable coating layer and at least a portion of the drug core, is cured (after drying) along with the uncured suture tab. The “cocuring” or one step curing process forms a very strong bond between the outer coating layer to the suture tab preventing leaks.

Abstract: A method for reducing the modulus of polymer silicone hydrogel compositions by employing monomeric polysiloxanes endcapped with trimethylsilyl to reduce the crosslinking density of the hydrogel. The synthesis consists of a single vessel acid catalyzed ring opening polymerization and may be employed to produce copolymers useful as hydrogel contact lens materials.

Abstract: An enucleated eye examination container 10 includes a housing 12 with an interior 14 to be pressurized. An eye retaining member 16 is contained within housing 12. An eye abutment portion 18 receives the eye 20 so that the eye 20 is urged against eye abutment portion 18 by eye retaining member 16. A connector 24 is attached to housing 12 for connection to a pressurized source of gas.

Abstract: A reciprocating tool post assembly is disclosed that may provide substantially linear excursions of a cutting tool mounted therein. The apparatus includes a voice coil assembly having a longitudinal axis that provides for the reciprocating movement of the assembly and to which a pair of coil arms is attached. The assembly also includes a pair of lever arms, each being pivotally attached between a respective coil arm and a draw bar, with a pair of fulcrum members attached to a base of the assembly that engage each respective lever arm to provide a fulcrum about which each respective lever arm may pivot. One end of the draw bar is attached to a tool support that is guided in a substantially axial movement by a guide member, such that, when a cutting tool is attached to the tool support and the movement of the voice coil causes the cutting tool to reciprocate substantially axially with respect to the base.

Abstract: A novel crystal holder for the wavelength dispersive spectrometers of electron microprobes arranges four crystals as a cylinder segment which may be moved to a position in which it partially encompasses the viewing optics assembly so that low Bragg angle settings may be obtained without mechanical interference, while at the same time the interchanging of crystals by oscillation of the cylinder segment on its axis is possible at any position of the crystal holder.

Abstract: An X-ray spectrometer is provided with two channels for detecting characteristic lines of the X-ray source after being scattered by a sample undergoing analysis, in addition to means for detecting electric signals primarily representative of the concentrations of analytes in the sample. In this way, data is collected which facilitates corrections of the measurements corresponding to individual analytes for deviations from linearity of intensity caused by variations in interelement effects, and by variations in total-solids concentration, or density, of the slurry, or matrix, in which the analytes are distributed, and by variations in particle size of the total-solids in the sample. Correction of measurements of total-solids concentration and average particle size of the matrix for each other and for effects of analytes, may also be made.