Abstract: An ophthalmic lens, comprising a central zone having at least a first power, and a peripheral zone having an add-power offset relative to the at least first power and a spatially-modulated optical parameter. In some embodiments, the central zone has a diameter in the range 2.0 to 5.0 mm. In some embodiments, the central zone is not more than 1 mm smaller than a wearer's pupil. The spatially-modulated optical parameter may include optical power, light scattering or light transmission.

Abstract: An ophthalmically compatible solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (d) one or more buffers.

Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.

Abstract: Ophthalmic compositions comprising an anti-allergen and a redness reduction agent, such as brimonidine or a pharmaceutically acceptable salt thereof, for treating itching and redness in a single composition. The ophthalmic compositions may be provided in a container closure system, such as a low density polyethylene bottle. Container closure systems and kits comprising the ophthalmic compositions are disclosed.

Abstract: An ophthalmic device for slowing, inhibiting or preventing myopia progression which is a polymerization product of a monomeric mixture comprising (a) greater than 50 wt. %, based on the total weight of the monomeric mixture, of one or more non-silicone-containing hydrophilic monomers; (b) one or more crosslinking agents; and (c) one or more red-light blocking compounds blocking greater than 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 800 nm, wherein the one or more red-light blocking compounds have one or more ethylenically unsaturated reactive end groups.

Abstract: A contact lens package, comprising blister packaging defining a cavity, a contact lens disposed in an unstressed state within the cavity, lens hydrating liquid partially filling the cavity, and lid stock sealed to the blister packaging such that a segment of the lid stock, in combination with the cavity, forms an enclosure of the lens and the liquid. The segment has an interior surface including at least one relief element. The interior surface exclusive of the at least one relief element is flat. An air gap is disposed between a top surface of the liquid and at least a portion of the interior surface. The at least one relief element on the interior surface of the lid stock may be formed while testing the structure for leaks by applying pressure to the lid stock with a stamp having a contour corresponding to the at least one relief element.

Abstract: A vitrectomy system includes a surgical cutting apparatus and a processor. The system includes a cutting assembly with an outer cutter and an inner cutter. The cutting assembly includes a housing containing a drive chamber, a spring chamber, at least a first diaphragm. The first diaphragm is adhered to the inner cutter and positioned between the drive chamber and the spring chamber. The system also includes a drive chamber valve to supply compressed air to the drive chamber and a spring chamber valve to adjust air pressure within the spring chamber. The processor is configured to pulse the drive chamber valve based on a desired cut rate to translate the inner cutter and adjust the air pressure within the spring chamber based on the desired cut rate to adjust the stiffness of the spring chamber.

Abstract: Methods for treating coronavirus disease 2019 (COVID-19), including at least one ocular manifestation of COVID-19, methods for treating conjunctivitis, and methods for reducing COVID-19 transmission comprising administering an effective amount of benzalkonium chloride are disclosed. Pharmaceutical compositions comprising benzalkonium chloride are also disclosed.

Abstract: A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.

Abstract: A contact lens package includes a first layer, a support coupled to the first layer, a lens, and a second layer. The support includes a scaffold and a porous member attached to the scaffold where the porous member includes a curved surface. The lens includes an anterior surface and a posterior surface, and the posterior surface of the lens is disposed on the curved surface of the porous member. The second layer is coupled to the first layer to seal the support and the lens between the first layer and the second layer.

Abstract: A biomedical device is disclosed which is a polymerization product of a mixture comprising (a) one or more difunctional isocyanates; (b) one or more polyalcohols; (c) one or more hydroxy-terminated polysiloxane prepolymers; and (d) one or more polyoxazoline polyols having a weight average molecular weight of equal to or greater than about 1000 Daltons.

Abstract: The present disclosure describes compositions comprising comprising vitamin C, vitamin E, zinc, copper, and a potent vitamin B complex and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.

Abstract: The present disclosure describes compositions comprising a potent vitamin B complex and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.

Abstract: The present disclosure describes compositions comprising at least one very long chain fatty acid chosen from C26+ acids (5n-3), prodrugs thereof, and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.

Abstract: A phacoemulsification handpiece for ocular surgery includes a housing including a grip for holding the phacoemulsification handpiece, a needle extending from the housing for removing ocular material from an eye, and a horn connected with the needle. The phacoemulsification handpiece also includes a driving circuit configured to vibrate the horn according to a multi-harmonic driving signal, to generate non-sinusoidal ultrasonic motion of a tip of the needle.

Abstract: A device for ocular surgery includes a surgical handpiece including a power cord and an aspiration needle for removing ocular material from an eye, and co-extruded tubing. The tubing includes an aspiration tube for receiving the ocular material removed from the eye by the surgical handpiece, an irrigation tube integrally formed with the aspiration tube for supplying irrigation fluid to the surgical handpiece, and a ridge defined along at least a majority of a length of the co-extruded tubing, the ridge defining a groove for receiving the power cord of the surgical handpiece.

Abstract: An ophthalmic lens, comprising a central zone having at least a first power, and a peripheral zone having an add-power offset relative to the at least first power and a spatially-modulated optical parameter. In some embodiments, the central zone has a diameter in the range 2.0 to 5.0 mm. In some embodiments, the central zone is not more than 1 mm smaller than a wearer's pupil. The spatially-modulated optical parameter may include optical power, light scattering or light transmission.