Abstract: The present invention relates to a retroviral vector system comprising a packaging cell line that synthesize the core and enzymatic proteins of MLV virus from one or more gag and pol containing constructs and the envelope of MMTV virus from the same or an independent env containing construct, and to pseudotyped retroviral particles produced by culturing said retroviral vector system transfected with a MLV based retroviral vector, and isolation of said pseudotyped retroviral particles.
Type:
Grant
Filed:
September 25, 1997
Date of Patent:
September 12, 2000
Assignees:
Bavarian Nordic Research Inst. A/S, GSF-Gessellschaft fur Umwelt und Gesundheit GmbH