Abstract: This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy.
Type:
Grant
Filed:
July 2, 2010
Date of Patent:
May 17, 2011
Assignees:
Baxter Health S.A., Baxter International, Inc.
Inventors:
Friedrich Scheiflinger, Manfred Rieger, Barbara Plaimauer