Abstract: A dialysis system includes a source of water; a concentrate for mixing with the water a disposable set including a pumping portion, a water line in fluid including a filter for filtering the water, a concentrate line in fluid communication with the source of water and the pumping portion; and a medical fluid delivery machine including a pump actuator operable with the pumping portion, a pressure sensor, and a control unit programmed to cause (i) the pump actuator to pump water to wet a membrane of the filter, thereafter remove at least some of the water from the filter, and pressurize a portion of the water line leading from the pumping portion to the filter, (ii) the pressure sensor to sense pressure in the pressurized portion of the water line, and (iii) an analysis of the sensed pressure to be performed to evaluate the integrity of the filter.

Abstract: An infusion pump including an interface unit for receiving first data for a first infusion regimen for a medication, the first regimen including a first unit of measure in which the first regimen is executed and after receipt of the first data, second data for a second infusion regimen for the medication, the second regimen including a second unit of measure in which the second regimen is executed. The pump also includes a processor for comparing the first and second units of measure. In one embodiment, the pump includes a graphical user interface, and the processor identifies a difference between the first and second units of measure; generates, using the processor, a warning message; and displays the message on the graphical user interface. In another embodiment, the processor holds in abeyance initiation of the second infusion regimen in response to identifying the difference between the units of measure.

Abstract: A peritoneal dialysis system includes: a dialysis fluid pump including a pump actuator and a dialysis fluid contacting portion actuated by the pump actuator; a fresh dialysis fluid valve located upstream of the pump and including a fresh valve actuator and a dialysis fluid contacting portion actuated by the fresh valve actuator; a patient line valve located downstream of the pump and including a patient line valve actuator and a dialysis fluid contacting portion actuated by the patient line valve actuator; a drain valve positioned and arranged to receive used dialysis fluid from the patient and including a drain valve actuator and a dialysis fluid contacting portion; a patient line extending from the drain valve; and a fluid loop including dialysis fluid contacting portions of the pump, the fresh dialysis fluid valve, the patient line valve and the drain valve, and wherein the patient line extends from the fluid loop.

Abstract: A disposable set for a peritoneal dialysis (“PD”) treatment includes a fresh PD fluid pumping portion (118a): a used PD fluid pumping portion (118b): a reusable tubing section (124f) including the fresh PD fluid pumping portion (118a) and a one-way valve (132), the reusable tubing section terminating at a first connector; and a disposable tubing section (124u) including the used PD fluid pumping portion (118b) and terminating at a second connector, the second connector configured to be connected to the first connector to form the disposable set for use in the PD treatment.

Abstract: Disclosed herein is a water purification apparatus capable of being cleaned at a point of care, and methods for cleaning the water purification apparatus at the point of care. The water purification apparatus and the methods provide an efficient use of a heater for heat disinfection the water purification apparatus, e.g. by recirculating heated fluid to further heat the fluid. Several different cleaning programs are provided that may be utilized for cleaning different parts of the water purification apparatus.

Abstract: Methods, systems, and apparatuses for integrating medical device data are disclosed. In an example embodiment, a server receives infusion therapy progress data that is generated by an infusion pump and renal failure therapy progress data that is generated by a renal failure therapy machine. The server also receives physiological data that is generated by at least one physiological sensor. The server determines fluid balance data based on a difference between the infusion therapy progress data and the renal failure therapy progress data. The server stores the fluid balance data in conjunction with hemodynamic information from the physiological data to a patient's medical record.

Abstract: In an aspect, a method of manufacture of a pharmaceutically acceptable solid composition containing daptomycin includes drying an aqueous solution containing (i) water, (ii) the daptomycin, (iii) sorbitol in an amount of about 1.2 wt. % to about 9.0 wt. % of total volume of the aqueous composition and (iv) mannitol in an amount of about 0.6 wt. % to about 9.5 wt. % of total volume of the aqueous composition to form the solid composition. The drying can include an sublimation drying of about ?25° C. to about 50° C. for a time period of about 15 hours to about 120 hours, most preferably about 15° C. for about 20 hours, optionally preceded and/or followed by one or more additional drying steps. Other aspects are the solid composition containing the daptomycin and also methods of treating a bacterial infection including administering a pharmaceutically acceptable product made by reconstituting the solid composition.

Abstract: The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure. And from pulse pressure and pulse transit time, a second algorithm, also employing a linear algorithm, can estimate systolic blood pressure and diastolic blood pressure. Thus, the sensor can measure all five vital signs along with hemodynamic parameters. It also includes a motion-detecting accelerometer, from which it can determine motion-related parameters such as posture, degree of motion, activity level, respiratory-induced heaving of the chest, and falls.

Abstract: A reconstitution device includes: a piercing member having a first end and a second end, the first end of the piercing member configured to engage an administration port; a delivery member having a first end and a second end, the first end of the delivery member configured to engage a delivery site; a collar configured to engage a vial; and a cap extending from the collar and holding the piercing member and the delivery member such that the second end of the piercing member and the second end of the delivery member are disposed within the cylindrical collar.

Abstract: A syringe pump including a housing with a syringe accepting region, a syringe holding system configured to hold a syringe in the syringe accepting region, a drive mechanism, and a drive head operatively coupled to the drive mechanism. The drive head is configured to engage a piston of a syringe held by the syringe holding system.

Abstract: A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.

Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; at least one pair of capacitive sensing plates; a manifold assembly including a rigid manifold having at least one chamber, the rigid manifold configured and arranged to be abutted against the actuation surface for operation, wherein the at least one pair of capacitive sensing plates is positioned to be operable with the at least one chamber; a peristaltic pump tube; and a control unit configured to actuate the peristaltic pump actuator to pump dialysis fluid to the at least one chamber, receive a signal from the at least one pair of capacitive sensing plates, count a number of revolutions of the peristaltic pump actuator, determine a current volume per revolution for the peristaltic pump actuator, and use the current volume per revolution for a subsequent operation of the peristaltic pump actuator.

Abstract: Compositions and methods for sealing tissue of a patient in a wet environment are disclosed.

Abstract: A system and method for self-aligning and connecting a device to a modular rack. The system includes a device comprising a connector receptacle configured to receive a connector plug, a connector seal and a bracket fixed to the device, a modular rack comprising the connector plug, a connector shell seal and a shelf configured to receive the bracket and guide the shelf in a plurality of directions. When the bracket of the device is inserted into the shelf of the modular rack, the shelf travels in the plurality of directions to self-align the connector plug of the modular rack to the connector receptacle of the device to ensure engagement of the connector plug to the connector receptacle. The connector seal is biased towards the connector shell seal to create a seal and ensure engagement of the connector plug relative to the connector receptacle.

Abstract: A parenteral nutritional diagnostic system, apparatus, and method are disclosed. In an example, a parenteral nutritional diagnostic apparatus determines muscle quantity and muscle quality of a patient's psoas muscle to determine a nutritional status of the patient. An image interface is configured to receive a medical image including radiodensity data related to imaged tissue of the patient. The apparatus also includes a processor configured to use the medical image to determine a tissue surface area for each different value of radiodensity and determine a distribution of the tissue surface area for each radiodensity value. The processor is configured to determine muscle quality by locating a soft tissue peak within the distribution that corresponds to a local peak in at a region related to at least one of muscle tissue, organ tissue, and intramuscular adipose tissue. The processor determines the nutritional status of the patient based on the soft tissue peak.

Abstract: A system includes a server including a clock and a plurality of medical devices in network communication with the server. Each medical device includes at least one alarm mechanism and an internal clock. A first medical device of the plurality of medical devices is configured to receive a clock synchronization data from the server, update the internal clock of the first medical device based on the clock synchronization data, provide an alarm signal of a first type at a first time, and provide a subsequent alarm signal of the first type at a second time. The second time occurs at a predetermined interval from the first time. Additionally, the second time is the same time the alarm signal of the first type is provided by a second medical device of the plurality of medical device.

Abstract: A priming sensor for a medical fluid delivery device is disclosed. In an example, the priming sensor includes light emitters and a detector. The detector is configured to detect light emitted by the emitters that interacts with a patient tube connected to the priming sensor. A processor of a medical fluid delivery device causes the emitters to operate in a sweep pattern during a sweep period. The processor receives output data from the detector that is indicative of light detected during the sweep period. The processor creates an output waveform corresponding to the sweep period based on the output data and compares the output waveform to at least one reference waveform to determine one of (a) a no-tube state, (b) a dry tube state, or (c) a wet tube state. The processor provides an output indicative of the comparison for operation of the medical fluid delivery device.

Abstract: A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.