Abstract: A process for the purification of influenza virus or derivative thereof requires providing a source of influenza virus or derivative thereof, optionally subjecting the source to a pre-purification step, followed by subjecting the source to at least one chromatographic step on chromatographic material selected from the group consisting of porous particles having mean pore sizes of at least 20 nm, perfusion particles, gel-in-a-shell particles, tentacle like particles, membrane adsorbers, and monoliths, and collecting fractions eluted from the chromatographic material that contain the influenza virus or derivative thereof, excluding sulfuric ester of cellulose or cross-linked polysaccharides.

Abstract: An automated peritoneal dialysis system and machine configured to perform dextrose mixing are disclosed. An example dialysis machine includes at least one pump, a first dialysate having a first dextrose level placed in fluid communication with the at least one pump, and a second dialysate having a second dextrose level placed in fluid communication with the at least one pump. The example dialysis machine also includes first and second valves placed between the first and second dialysates and the at least one pump. The example dialysis machine further includes a logic implementer programmed to operate the at least one pump and the first and second valves to mix the first and second dialysates so as to form a third dextrose level.

Abstract: An optical imaging assembly is provided, having an optical axis; an object axis defined by an object being imaged; an aperture stop disposed on the optical axis; a light-transmissive sleeve enclosing the object axis, being disposed in object space defined by the object axis; and at least three refractive lens elements being arranged between the object and the aperture stop without any other intervening optical component, at least one of the elements having surfaces having at least one of cylindrical and acylindrical prescription, with an image plane, wherein the object being imaged lies within the sleeve.

Abstract: A therapy management development platform includes a pump controller coupled to an interface module. The interface module includes an interface module controller and a module-sensor input/output interface including at least one standardized input port, output port and power connection. The interface module is also customizably programmed to receive data from a sensor and to provide instructions to the pump controller to vary the operation of a pump coupled thereto according to one of a plurality of levels of functionality. Upon receipt of an indication of approval from a remote computer to change the level of access to the functionality of the platform, the interface module may be customizably programmed to receive different data from the sensor, to provide different instructions to the pump controller, or both, the approval corresponding to a stage in testing of a medical device.

Abstract: A computer module for managing medical information is described. Aspects of the invention provide a “binding” or association process for mapping information from a patient, including at the bedside, to medical devices and/or locations containing medical devices. This may advantageously allow combining all patient-bound device data in a single repository and effectively enable viewing of all patient data in one location. Accordingly, numerous discrete device data with respect to a single patient may be captured, including from among differing medical device types, and conveniently stored together as part of an intelligent data warehouse for efficient retrieval, updating, processing, including with respect to data analytics, display and/or other advantageous features. A medical device communication system is also described.

Abstract: A dialysis system includes a disposable cassette including a flexible sheet and a plurality of dialysis fluid pathways, a plurality of actuators operable with the flexible sheet to direct dialysis fluid through the plurality of dialysis fluid pathways, and a controller configured to (i) determine at least one limitation of the plurality of dialysis fluid pathways, (ii) generate a flow schedule indicating how dialysis fluid should be directed through the plurality of dialysis fluid pathways in accordance with the at least one limitation, and (iii) control the plurality of actuators so that dialysis fluid is pumped through the plurality of dialysis fluid pathways according to the flow schedule.

Abstract: A welding apparatus for use in welding first and second sheets of material together includes a seal die, a platen, a control unit, and a power source adapted to provide energy to the seal die. The seal die is made of a conductive material and is configured to impart thermal-mechanical energy to the first and second sheets of material. The seal die includes a bottom surface configured to contact the first sheet, an inner edge, a chamfer extending between the bottom surface and the inner edge, a first blend radius, and a second blend radius. The first radius extends between the chamfer and the bottom surface, while the second radius extends between the chamfer and the inner edge. The platen is configured to support the second sheet, while the control unit is programmed to cause the seal die to be directed towards the platen.

Abstract: A dialysis system comprising a sorbent cartridge for fluidly communicating with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication with the sorbent cartridge and the storage container; and a control unit in operable communication with the pump to cause the pump to (i) recirculate a dialysis fluid through the sorbent cartridge for at least two recirculation cycles such that the dialysis fluid in each cycle contacts the zirconium phosphate layer first before contacting the at least one of the urease layer, zirconium oxide layer or carbon layer, and (ii) store the dialysis fluid in the storage container after the at least two recirculation cycles.

Abstract: A medical fluid pneumatic manifold system includes a first plate including a plurality of apertures, a second plate attached to the first plate so as to form a plurality of pneumatic flowpaths sealed between the first plate and the second plate, a plurality of tubing connections and a plurality of pneumatic tubes connected to the plurality of tubing connections, the plurality of tubing connections placing the plurality of pneumatic tubes in pneumatic communication with the plurality of pneumatic flowpaths via the plurality of apertures of the first plate, and a pneumatic reservoir in pneumatic communication with the plurality of pneumatic flowpaths, the pneumatic reservoir configured to provide pneumatic pressure to the plurality of pneumatic tubes.

Abstract: Methods, systems, and apparatuses for integrating medical device data are disclosed. In an example embodiment, an integration engine includes a configuration interface configured to receive a patient identifier. The integration engine also includes a subscription processor configured to transmit a first message, including the patient identifier, to a first gateway to receive infusion therapy progress data from at least one infusion pump and transmit a second message, including the patient identifier, to a second gateway to receive renal failure therapy progress data from at least one renal failure therapy machine. The integration engine further includes a data processor configured to receive the infusion therapy progress data from the first gateway, receive the renal failure therapy progress data from the second gateway, and cause a combination user interface to display the infusion therapy progress data and the renal failure therapy progress data.

Abstract: Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.

Abstract: A renal therapy apparatus includes a blood filter, a blood pump, a treatment fluid pump, and a control unit configured to control at least one of the blood pump or the treatment fluid pump during a filter cleaning sequence. In a first phase of the filter cleaning sequence, a first fluid including a blood-compatible and physiologically safe fluid is transferred back and forth across the insides and/or outsides of the blood filter. After the first phase, a second fluid is formed by mixing the first fluid with air. In a second phase of the filter cleaning sequence, the second fluid is transferred across the insides and/or outsides of the blood filter at least one time.

Abstract: A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.

Abstract: Methods and apparatuses for regenerating used dialysis fluid are described herein. In an embodiment, a regenerative dialysis fluid system includes a dialysis unit configured to generate used dialysis fluid including urea, a urea separation unit configured to separate at least a portion of the urea from the used dialysis fluid into a secondary fluid, and a urea removal unit configured to remove at least a portion of the urea from the secondary fluid and return the secondary fluid to the urea separation unit. In an embodiment, the urea separation unit includes a membrane separating a dialysis fluid chamber from a urea chamber, the membrane including at least one of: (i) a positive charge to prevent positive ions from transporting across the membrane; and (ii) a negative charge to prevent negative ions from transporting across the membrane.

Abstract: A handheld personal communication apparatus for dialysis includes: a reader to (i) read a marking displayed on a dialysis fluid container to acquire data concerning at least one of a dialysis fluid type or a dialysis fluid volume from the marking, and/or (ii) receive a patient weight signal from a weight scale; a processor using at least one of the dialysis fluid type, dialysis fluid volume, or patient weight to determine a dialysis dwell time for at least one cycle of a dialysis therapy, the dialysis dwell time being a time to achieve, over the at least one cycle, at least one of (a) a specified ultrafiltrate level, (b) a urea removal level, or (c) a creatinine removal level; and an output interface providing an indication to the patient of a completion of the dialysis dwell time.

Abstract: A hybrid hemodialysis (“HD”)/peritoneal dialysis (“PD”) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.

Abstract: An infusion pump including an interface unit for receiving first data for a first infusion regimen for a medication, the first regimen including a first unit of measure in which the first regimen is executed and after receipt of the first data, second data for a second infusion regimen for the medication, the second regimen including a second unit of measure in which the second regimen is executed. The pump also includes a processor for comparing the first and second units of measure. In one embodiment, the pump includes a graphical user interface, and the processor identifies a difference between the first and second units of measure; generates, using the processor, a warning message; and displays the message on the graphical user interface. In another embodiment, the processor holds in abeyance initiation of the second infusion regimen in response to identifying the difference between the units of measure.