Patents Assigned to Baxter Healthcare
  • METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE
    Publication number: 20120035110
    Abstract: Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH4+) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.
    Type: Application
    Filed: July 8, 2011
    Publication date: February 9, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: LEOPOLD GRILLBERGER, MANFRED REITER, WOLFGANG MUNDT
  • DIALYSIS SYSTEM INCLUDING WIRELESS PATIENT DATA AND TRENDING AND ALERT GENERATION
    Publication number: 20120035534
    Abstract: A peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine including a logic implementer and a wireless interface receiver. The system also includes at least one of a scale or a blood pressure monitor including a wireless interface transmitter. The scale or blood pressure monitor is operable to send at least one of patient blood pressure data and patient weight data wirelessly, respectively, to the wireless interface receiver. The logic implementer is configured to store the patient blood pressure data or patient weight data. A server computer is configured to communicate with the logic implementer to receive the stored at least one patient blood pressure data and patient weight data.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Anping Yu, James Grayson, Robert W. Childers
  • PERITONEAL DIALYSIS MACHINE TOUCH SCREEN USER INTERFACE
    Publication number: 20120035533
    Abstract: A peritoneal dialysis machine including a membrane pump and a touch screen display that includes a mode-indicating portion and an operation-descriptive portion, the mode-indicating portion having a plurality of touch sensitive indicia each indicating one of a plurality of modes in which the machine can operate, the display being used to keep a patient continually informed of which one mode of at least three operating modes the machine is operating in, as the operation-descriptive portion changes to display details of a specific operation being carried out within the one mode, the indicia for each of the three operating modes always being visible to the patient while the machine is operating, the operating mode being selected by the patient touching one of the indicia on the screen.
    Type: Application
    Filed: January 28, 2011
    Publication date: February 9, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Andrea (Krensky) Britton, Donald Busby, Eric Callahan, Robert Childers, Peter Hopping, Seyed Khorashahi, William Reese, Randall Sharo, Debra Toczko, Li Yue
  • METHOD OF PRODUCING RECOMBINANT ADAMTS13 IN CELL CULTURE
    Publication number: 20120034674
    Abstract: Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH4+) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.
    Type: Application
    Filed: July 8, 2011
    Publication date: February 9, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Leopold Grillberger, Manfred Reiter, Daniel Fleischanderl, Gregor Bramberger
  • THERAPY PREDICTION AND OPTIMIZATION FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS
    Publication number: 20120029324
    Abstract: A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.
    Type: Application
    Filed: April 15, 2011
    Publication date: February 2, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Alp Akonur, John Kenneth Leypoldt, Ying-Cheng Lo, Baris Ugur Agar
  • TFPI INHIBITORS AND METHODS OF USE
    Publication number: 20120028901
    Abstract: The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
    Type: Application
    Filed: February 11, 2011
    Publication date: February 2, 2012
    Applicants: BAXTER INTERNATIONAL INC., 3B PHARMACEUTICALS GMBH, BAXTER HEALTHCARE S.A.
    Inventors: MICHAEL DOCKAL, RUDOLF HARTMANN, MARKUS FRIES, FRIEDRICH SCHEIFLINGER, HARTMUT EHRLICH, ULRICH REINEKE, FRANK OSTERKAMP, THOMAS POLAKOWSKI
  • Mobile dialysis system having supply container detection
    Patent number: 8105266
    Abstract: A dialysis system includes a dialysis instrument including at least one pump actuator; a disposable cassette operable with the at least one pump actuator; a plurality of supply containers connected fluidly to the disposable cassette; and a cart which includes a rotatable bearing plate onto which the instrument and supply containers are loaded, the bearing plate allowing a patient to turn the instrument and supply containers relative to the cart for selective access to the instrument or the supply containers.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: January 31, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Rodolfo Roger
  • Citrate anticoagulation system for extracorporeal blood treatments
    Patent number: 8105258
    Abstract: A hemofiltration system and method for pumping blood from a patient's blood stream into an access line, introducing an anticoagulant solution into the pumped blood, filtering the pumped blood and delivering it to a return line, introducing a substitution fluid into the pumped blood, introducing a calcium and magnesium solution into the blood traveling through the return line, and returning the blood back to the patient's blood stream.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: January 31, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Jean-Michel Lannoy
  • In situ tubing measurements for infusion pumps
    Patent number: 8105269
    Abstract: An infusion pump uses sensors and a computer program to detect tubing in a tube-loading section of the pump. The pump and the computer program also measures one or more of the tubing outer diameter, outer circumference, inner diameter, inner circumference, and tubing wall thickness. The infusion pump utilizes proximity sensors, such as an ultrasonic sensor, a capacitive sensor, or even an air-in-line sensor to detect proximity between two infusion pump surfaces, such as the surfaces that clamp the tubing in the pump, to determine thickness. At least one of the clamping surfaces is equipped with sensors to indicate contact length of the tubing with the surface. Using these measurements, the tubing wall thickness and inner diameter can be determined. Knowing the actual tubing inner diameter, increased volumetric accuracy is possible, up to a three or four percent improvement over present measurements.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: January 31, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Yu Zhou
  • DIALYSIS SYSTEM HAVING DISPOSABLE CASSETTE
    Publication number: 20120022440
    Abstract: A dialysis system includes a dialysis instrument and a disposable cassette. The dialysis instrument includes three pump actuators. The disposable cassette includes three dialysate pump chambers. The three dialysate pump chambers are positioned and arranged to operate with the three dialysate pump actuators of the dialysis instrument.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 26, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Robert W. Childers, David B. Howard, Peter A. Hopping
  • MEDICAL FLUID PUMP VALVE INTEGRITY TEST METHODS AND SYSTEMS
    Publication number: 20120022441
    Abstract: A valve integrity method for a medical fluid pump includes pumping fluid into the medical fluid pump while an outlet valve is closed and an inlet valve is open, closing the inlet valve while the outlet valve is closed, attempting to pump fluid out of the medical fluid pump while the inlet valve and the outlet valve are closed, and determining that at least one of the valves is leaking if a change in medical fluid volume within the medical fluid pump is detected.
    Type: Application
    Filed: September 30, 2011
    Publication date: January 26, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • DIALYSIS SYSTEM AND MACHINE HAVING THERAPY PRESCRIPTION RECALL
    Publication number: 20120022442
    Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.
    Type: Application
    Filed: October 3, 2011
    Publication date: January 26, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Anping Yu, Robert W. Childers, Borut Cizman
  • PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS
    Publication number: 20120021058
    Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, c) filling said coagulation inducing agent coated polymer granules into a final container, d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition.
    Type: Application
    Filed: June 1, 2011
    Publication date: January 26, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventor: Andreas Goessl
  • RENAL FAILURE THERAPY MACHINES AND METHODS INCLUDING CONDUCTIVE AND CONVECTIVE CLEARANCE
    Publication number: 20120018378
    Abstract: A renal failure therapy method includes causing therapy fluid to flow to a renal failure therapy filter, directing at least twenty-five percent of the therapy fluid to the renal failure therapy filter to perform conductive clearance, and using the renal therapy failure filter to cause at least a substantial amount of the remaining therapy fluid to perform diffusive clearance.
    Type: Application
    Filed: September 30, 2011
    Publication date: January 26, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • CHIMERIC OSPA GENES, PROTEINS, AND METHODS OF USE THEREOF
    Publication number: 20120020973
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: May 13, 2011
    Publication date: January 26, 2012
    Applicants: BAXTER INTERNATIONAL INC., Brookhaven Sciences Associates, LLC, Research Foundation of the State University of New York, BAXTER HEALTHCARE S.A.
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Barrier films containing microlayer structures
    Patent number: 8097346
    Abstract: Films containing microlayer structures are provided. In a general embodiment, the present disclosure provides a film containing a first microlayer of a heat resistant polymer and a second microlayer of a barrier polymer having a heat distortion temperature ranging between about 50° C. and about 120° C. attached to the first microlayer. Each of the first microlayer and the second microlayer has a thickness ranging from about 0.01 microns to about 10 microns.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: January 17, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Moh-Ching Oliver Chang, Michael Tung-Kiung Ling, Yuanpang S. Ding
  • Method and apparatus for measuring the presence and concentration of pharmaceutical substances in a medical fluid administered by a medication delivery system
    Patent number: 8094307
    Abstract: Test equipment determines the contents of medical fluids to be delivered to a patient by a medication delivery system by measuring optical properties of the fluids. One system provides a non-invasive test that uses optical rotation caused by optically active pharmaceutical substances to determine the presence or absence of the pharmaceutical substances within a medical fluid. Another system provides a non-invasive test that uses refractive index properties to determine the concentration of a pharmaceutical substance within the fluid. A method for use is also disclosed.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: January 10, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: James S. Slepicka
  • Dry hemostatic compositions and methods for their preparation
    Patent number: 8092820
    Abstract: Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: January 10, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Zhen Qian, A. Edward Osawa, Cary J. Reich
  • METHOD OF ISOLATION AND PURIFICATION OF TRYPSIN FROM PRONASE PROTEASE AND USE THEREOF
    Publication number: 20120003691
    Abstract: The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT.
    Type: Application
    Filed: December 28, 2009
    Publication date: January 5, 2012
    Applicant: Baxter Healthcare S.A.
    Inventors: Artur Mitterer, Christa Tauer, Manfred Reiter, Wolfgang Mundt
  • TUBE MEASUREMENT TECHNIQUE USING LINEAR ACTUATOR AND PRESSURE SENSOR
    Publication number: 20110319823
    Abstract: An infusion pump uses sensors, movable members and a control unit to determine tubing thickness in a tube-loading section of the pump. The infusion pump utilizes sensors, such as a pressure sensor, to record forces imparted by a tube undergoing no pressure, a single pressure, or a pressure sweep, to determine thickness. Using these values, the tubing wall thickness can be determined. The infusion pump can also compress a tube using a movable member of the pump and records the distance traveled by the movable member to compress fully the tube. Using this distance, the tubing wall thickness can be determined.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 29, 2011
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Peter M. Bojan, Zhengyan Wang, Surya Rai, Paul Olczak