Abstract: A medical fluid processing device for processing blood or other fluids includes a plurality of hardware elements that perform specific functions. Different processing procedures are achieved by performing the specific functions in appropriately arranged sequences and combinations. A user accessible menu permits user selection of the desired processing procedure. A software implemented "virtual" interface generates appropriate hardware commands for actuating the hardware elements as needed to achieve the desired processing procedure. A dual region, user-accessible screen provides user interaction with the processing device. The "virtual" interface provides positive control over the individual hardware elements in combination with sufficient system flexibility to achieve useful interactivity with the processing device operator.

Abstract: Stabilized and activated Factor VIII is used as a therapeutic agent to treat patients with a Factor VIII deficiency. This includes hemophilia A patients as well as patients with Factor VIII inhibitors which block the hemostatic activity of Factor VIII. The stabilized and activated Factor VIII is also prepared in a therapeutic composition with a therapeutically acceptable adjuvant.

Abstract: Systems and methods for separating mono nuclear cells from whole blood rotate a separation chamber about a rotational axis. The systems and methods introduce whole blood into a first region of the chamber during its rotation to separate the whole blood into a plasma constituent, red blood cells, and an interface between the red blood cells and the plasma constituent. The interface carries mono nuclear cells. While conveying whole blood into the first region, the systems and methods collect the plasma constituent in the first region, while also collecting the red blood cells in a second region of the chamber spaced from the inlet region. The systems and methods create, while conveying whole blood into the inlet region, a back flow of plasma constituent along the interface from the second region toward the inlet region. This back flow of plasma maintains a high-relative hematocrit in the second region and a low-relative hematocrit in the inlet region.

Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.

Abstract: Methods for enhancing vascular support of cells housed within an implanted apparatus are disclosed. The methods comprise placing a population of therapeutic substance-producing cells into the cell receiving chamber of an immunoisolation apparatus, implanting the apparatus into a patient, and administering an immunomodulatory agent to the patient. The immunomodulatory agent increases the number of close vascular structures in the vicinity of the implanted device, which increases the long term survival of the cell population housed therein.

Abstract: A disposable blood pressure sensor assembly (10) includes a blood pressure sensor module (12), an electrical cable (18) extending from the blood pressure sensor module (12), and an electrical connector (20) carried on the electrical cable (18). The electrical connector (20) forms a projecting portion (38) having an end surface (58). The electrical cable (18) has a cable jacket (68) which forms an end surface (66). The electrical connector (20) includes a conductor contact portion (60) of each of the electrical conductors (62) of the electrical cable (18), which conductor contact portion (60) is un-insulated and is arrayed and disposed outwardly on the connector (20) for direct electrical contact. Connector end surface (58) and cable jacket end surface (66) cooperatively define the surface across which conductor contact portions (60) extend.

Abstract: Systems and methods locate at least three spaced apart sensing units in association with volume of blood comprising a first blood component region, a second blood component region, and an interface region between the first and second blood component regions. The systems and methods locate at least one of the sensing units so that its optical field lies above the interface region and at least one of the sensing units so that its optical field lies below the interface region. Each sensing unit senses the attenuation of energy emitted into blood in its optical field and generates a signal relating to the attenuation. The systems and methods convert the signals to a signal vector of signal values having a shape approximated by a function. The systems and methods normalize the signal vector, and also create a vector of convolution signal values by multiplying the normalized signal vector by the function. The systems and methods identify the sensing unit associated with the highest convolution signal value.

Abstract: A system and method is provided which substantially eliminates the effect of air entrapped in tubing for delivering a liquid from a container. The inner diameter of the tubing is selected such that the gravitational force of the liquid from the container is greater than the surface tension of the liquid. A release agent may be used as a coating layer on the interior wall in addition to or alternatively from an expanded diameter.

Abstract: A method for separating blood into its components and individually storing same is provided. The method has the steps of: providing a container having a body with at least a first and second chamber. Selective fluid communication is also possible between the first and second chamber, and a tube is in fluid communication with the first chamber. The method also has the steps of: passing the blood into the first chamber through the tube; centrifuging the container to separate the blood into plasma, red blood cells and buffy coat within the first chamber; and expressing a portion of the centrifuged blood into the second chamber. In another embodiment, the method for storing blood has the steps of: providing a container with a body having three chambers.

Abstract: A multiple chamber container for mixing and administering a plurality of products. The container has at least two chambers separated by a seal line. A frangible connector is situated between the two chambers for mixing the products contained within the chambers as desired. Each chamber has at least one port for filling of product into the chamber. The ports are located on the same exterior side of the container such that the chambers can be filled without folding the bag and by using existing filling equipment.

Abstract: A system and a method are provided for detecting a bag that has been subjected to a process, such as illumination, wherein the contents of the bag require processing before subsequent use. The system (1) has a drawer (10) on which one or more bags may be placed and properly oriented. Punches (22) are provided for punching slugs from the bag indicative of a status of the processing of the bag. The punches (22) are aligned with die apertures (26) of a die (24) and corresponding punch apertures (20) through the drawer (10). The bag may include polarizing materials (50) such that the status of the processing of the bag (52) may be sensed. To this end, a rotating polarizing piece (70) is provided as well as a light source (34) and a sensor (38). The polarities between the polarizing piece (50) of the bag and the rotating polarizing piece (70) is monitored by the sensor (38) to indicate a condition or status of the processing of the bag and/or to further indicate tampering taking place in the process.

Abstract: A bileaflet mechanical cardiovascular valve comprising an annular valve body having a pair of occluder leaflets pivotally mounted therewithin. The occluder leaflets are pivotally mounted within the valve body by the snap-fitting of ear member which extend from the top and bottom ends of the occluder leaflets into corresponding cropped pivot slots formed within the annular valve body. Each cropped pivot slot comprises a spheroidal depression or recess having a first flat cropped edge and a second flat cropped edge. The ear members of the occluder leaflets are sized and configured relative to the cropped pivot slots to facilitate opening and closing of the occluder leaflets with minimal likelihood of hemolysis or thrombotic complications. Additionally disclosed is a specialized machine tool and method for machining the cropped pivot slots in the annular valve body.

Abstract: A medical infusion pump (10) using a pump chamber cassette (86) has a housing (20,22) defining a pump chamber cassette receptacle (84) and a pump driving mechanism (250) for propelling liquid through the pump chamber cassette. A door (50) holds the pump chamber cassette (86) within the cassette receptacle (84) in an operative position relative to the driving mechanism (250). The cassette includes an elastomeric conduit (132), a frame (134) and clips (146,148) for attaching the elastomeric conduit (132) to the frame (134) for holding the elastomeric conduit (132) in a select position relative to the pump driving mechanism (250) of the infusion pump upon placement of the cassette (86) in an operative position relative to the pump driving mechanism (250).

Abstract: A centrifuge comprising a yoke element that rotates about a rotational axis and a processing chamber having an axis. The processing chamber includes a bowl element, a spool element, and a mechanism for joining the spool and bowl elements for relative movement between a mutually cooperating position for centrifugal processing and a mutually separated position for loading. A hinge attaches the processing chamber to the yoke element for pivotal movement between an operating position and an access position. In the operating position, the spool and bowl elements are in their mutually cooperating position and oriented for rotation with the yoke element about the rotational axis. In the access position, the processing chamber axis lies outside the axis of rotation and the spool and bowl elements are oriented for movement from their mutually cooperating position into their mutually separated position.

Abstract: A method for preparing thin fluoropolymer (PTFE) films, said method generally having the steps of: a) providing an unsintered fluoropolymer film; b) pre-sintering expansion of the film; c) sintering the expanded film with dimensional restraint to prevent shrinkage; and d) post-sintering stretching of the film to a final thickness preferably less than 0.002 inches. The post-sintering stretching of the film in step d may be accomplished in a single step, or may include a series of post-sintering stretching steps. Steps b and c of the method may be carried out bypassing the calendared film through a machine direction orienter device and, thereafter, step d of the method may be accomplished by subsequently repassing the sintered film through the machine direction orienter device, one or more additional times.

Abstract: An insert nestingly receivable within a centrifuge cup to support a pair of fluid containing bags therein is formed from a pair of concave shapes having an upper end and a lower end and which are centrally adhered together in back-to-back relationship. The shapes together with an interior surface of the centrifuge cup together form a pair of elliptically shaped chambers for supporting a pair of the bags within the cup. A pair of pins extend through the concave shapes and extend outwardly therefrom. The bags each are provided with a pair of spaced-apart holes to receive the pins, thereby supporting the bags within the elliptically shaped chambers. Preferably a block is fitted between the adhered together surfaces of the shapes at each lateral edge at the lower ends thereof. These blocks preferably extend laterally outwardly beyond the lateral extremities of the shapes, and the edges of the concave shapes and the blocks are rounded to thereby be nestingly receivable in the interior of the cup.

Abstract: A peristaltic pumping apparatus includes a pump rotor carrying a roller and a drive mechanism for rotating the rotor. The drive mechanism includes a carrier for holding the pump rotor. The apparatus includes a release pin mechanism carried on the pump rotor and exposed to access by a user. The release pin mechanism is movable by the user between a first position that connects the pump rotor to the carrier and a second position that disconnects the pump rotor from the carrier. Placing the release pin mechanism in the second position allows quick separation of the pump rotor from the drive mechanism.

Abstract: Variably compliant natural tissue valve leaflets and vascular bioprosthetics incorporating variably compliant leaflets are provided along with methods for their manufacture. The variably compliant leaflets are fixed with the leaflet base section under greater pressure than the leaflet tip section rendering them relatively stiff along the leaflet base section and more flexible at the leaflet tip section. The radially variable flexing characteristics of the valve leaflets promote even distribution of mechanical stress on the valve assembly during the cardiac cycle leading to improved hemodynamic performance while retarding the calcification of the leaflet tissue.