Patents Assigned to Bayer AG
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Publication number: 20230000454Abstract: Embodiments of the present invention relates to an X-ray contrast agent. The X-ray contrast agent has an X-ray absorption the change of which between at least two different X-ray photon energy levels differs from the change in X-ray absorption of calcium between the at least two different X-ray photon energy level. Embodiments of the present invention also relates to an X-ray imaging method. Embodiments of the present invention additionally relates to an image reconstruction device. Embodiments of the present invention further relates to an X-ray imaging system.Type: ApplicationFiled: November 4, 2020Publication date: January 5, 2023Applicants: Siemens Healthcare GmbH, Bayer AGInventors: Thomas FLOHR, Bernhard SCHMIDT, Gregor JOST, Hubertus PIETSCH
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Publication number: 20220401588Abstract: An ensemble of at least two X-ray contrast agents includes X-ray contrast agent and a second X-ray contrast agent. The second X-ray contrast agent has an X-ray absorption whose change between at least two different X-ray photon energies differs significantly from the change of the X-ray absorption of the first X-ray contrast agent between the at least two different X-ray photon energies. An X-ray imaging method, an image reconstruction device, an X-ray imaging system are also disclosed.Type: ApplicationFiled: November 4, 2020Publication date: December 22, 2022Applicants: Siemens Healthcare GmbH, Bayer AGInventors: Thomas FLOHR, Bernhard SCHMIDT, Gregor JOST, Hubertus PIETSCH
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Patent number: 10898500Abstract: The present invention relates to pharmaceutical compositions and combinations comprising regorafenib and acetylsalicylic acid, or a hydrate, solvate, metabolite or pharmaceutically acceptable salt thereof or a polymorph thereof for treating, preventing or managing diseases and conditions including hyperproliverative disorders such as cancer in humans and other mammals.Type: GrantFiled: September 23, 2013Date of Patent: January 26, 2021Assignees: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AGInventors: Olaf Weber, Karl Ziegelbauer
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Patent number: 10834914Abstract: A pest monitoring system and associated method includes pest monitoring devices for placement at a site and generating a signal upon detection of a pest, and a pesticide dispensing unit including a reservoir housing a diluent and a pesticide module housing a pesticide. A computer device remotely disposed to the pest monitoring devices receives generated signals therefrom, analyzes environmental and historical factor data for the site to determine an amount and placement location of the pest monitoring devices for monitoring the site, and directs deployment of the pest control monitoring devices according to the analysis. The computer device also receives data from the pesticide dispensing unit including an amount or rate of the pesticide substance dispensed from the pesticide module, to form treatment having a concentration of the pesticide substance in the diluent, the treatment being dispensed from the pesticide dispensing unit to treat a detected pest at the site.Type: GrantFiled: April 12, 2017Date of Patent: November 17, 2020Assignee: Bayer AGInventors: Byron Reid, Volker Gutsmann, Michael Zimmermann, Chris Pienaar, Gaelle Fages, Peter Jardine
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Patent number: 10152035Abstract: The instant disclosure provides an ability to use an array of data inputs to enter a network and thereby provide a realtime improvable database. The present invention is novel in its ability to maximize the customer's interface with a pest control system, thus allowing for maximum efficiency for current and future designs as well as a high level of compatibility with ancillary regulatory, financial and planning type functions.Type: GrantFiled: April 12, 2017Date of Patent: December 11, 2018Assignee: BAYER AGInventors: Byron Reid, Volker Gutsmann, Michael Zimmermann, Chris Pienaar, Gaelle Fages, Peter Jardine
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Patent number: 9285312Abstract: The invention relates to a reflection probe for measuring properties of liquid and/or solid substances, and to the use thereof.Type: GrantFiled: January 24, 2013Date of Patent: March 15, 2016Assignee: Bayer AGInventors: Stephan Tosch, Reinhard Gross, Nils Weber
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Publication number: 20150202214Abstract: The present invention relates to pharmaceutical compositions and combinations comprising regorafenib and acetylsalicylic acid, or a hydrate, solvate, metabolite or pharmaceutically acceptable salt thereof or a polymorph thereof for treating, preventing or managing diseases and conditions including hyperproliverative disorders such as cancer in humans and other mammals.Type: ApplicationFiled: September 23, 2013Publication date: July 23, 2015Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AGInventors: Olaf Weber, Karl Ziegelbauer
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Patent number: 8078323Abstract: Method for controlling the process of separating mixtures containing several substances having close boiling points and with a known concentration, in a distillation column, wherein the concentration of at least one component is measured at a midpoint of the column, and said measurement, together with other parameters, is used to control the process.Type: GrantFiled: September 6, 2002Date of Patent: December 13, 2011Assignee: Bayer AGInventors: Frank Meeuwssen, Franz Ferdinand Rhiel, Torsten Hauschild, Martin Gerlach
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Patent number: 7514565Abstract: The invention relates to compounds of the formuleType: GrantFiled: December 15, 2006Date of Patent: April 7, 2009Assignee: Bayer AGInventors: Jürgen Stoltefuβ, Siegfried Goldmann, Thomas Krämer, Karl-Heinz Schlemmer, Ulrich Niewöhner, Maria Niewöhner, Arnold Paeβens, Erwin Graef, Stefan Lottmann, Karl Deres, Olaf Weber, Jörn Stölting
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Patent number: 7256158Abstract: The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups ?wherein A, B, D, G, X, Y and Z have the meaning given in the description, several processes and intermediate products for their preparation and their use as pest control agents and herbicides.Type: GrantFiled: August 20, 2004Date of Patent: August 14, 2007Assignee: Bayer AGInventors: Folker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Peter Dahmen, Markus Dollinger, Hans Joachim Santel, Alan Graff, Norbert Mencke, Andreas Turberg
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Publication number: 20070129355Abstract: The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.Type: ApplicationFiled: April 14, 2004Publication date: June 7, 2007Applicants: ACTIMIS PHARMACEUTICALS, INC., BAYER AG, BAYER HEALTH CARE AGInventors: Tai-wei Ly, Yuji Koriyama, Takashi Yoshino, Hiroki Sato, Kazuho Tanaka, Hiromi Sugimoto, Yoshihisa Manabe, Kevin Bacon, Klaus Urbahns, Masanori Seki, Takuya Shintani
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Patent number: 7208175Abstract: Rapidly disintegrating preparations containing at least one active pharmaceutical ingredient and at least one excipient can be obtained by a simple process in which at least the predominant part of the complete composition of the ingredients for the preparation to be produced is granulated, the resulting granules and, where appropriate, the remainder of the ingredients are shaped in the presence of liquid virtually without pressure, and the resulting shaped articles are dried.Type: GrantFiled: June 19, 2003Date of Patent: April 24, 2007Assignee: Bayer AgInventors: Marco Schroeder, Klaus-Jürgen Steffens
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Patent number: 7112660Abstract: The invention relates to methods for the stabilisation of cytokines and to cytokines generated by such methods. The methods of the invention involve mutating the amino acid sequence of a cytokine so as to remove solvent-exposed hydrophobic residues, and/or mutating the amino acid sequence of the cytokine so as to stabilise one or more secondary structure elements in the molecule. These steps have the effect of destabilsing intermediates that are formed during the folding process, relative to the stability of the cytokine in its naturally folded state, so increasing the yield of the cytokine as produced in vitro.Type: GrantFiled: May 23, 2000Date of Patent: September 26, 2006Assignees: European Molecular Biology Laboratory, Bayer AGInventors: Helena Domingues, Hartmut Oschkinat, Luis Serrano, Joerg Peters
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Patent number: 7091284Abstract: Hydrogenated copolymers of an unsaturated nitrile, butadiene and isoprene, wherein the molar ratio of butadiene to isoprene is less than 3:1, display valuable low temperature properties.Type: GrantFiled: August 21, 2001Date of Patent: August 15, 2006Assignees: Bayer AG, Bayer Inc.Inventors: Harald Bender, Rotraud Casper, legal representative, Hans Rafael Winkelbach, Hans Christian Strauch, Paul Nguyen, Sharon X. Guo, Janet Gamlin, Rudolf Casper, deceased
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Patent number: 7025978Abstract: The present invention relates to the use of polysiloxanes containing at least one quaternary ammonium group as formulation auxiliaries in formulations of pharmaceutically and veterinary active compounds, and to compositions comprising a) pharmaceutically or veterinary active compound and b) a polysiloxane derivative containing at least one quaternary ammonium group per molecule, if appropriate, further auxiliaries and carriers.Type: GrantFiled: October 31, 2000Date of Patent: April 11, 2006Assignee: Bayer AGInventors: Kirkor Sirinyan, Kerstin Heinen
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Patent number: 7012041Abstract: The invention relates to novel phenylpyridazinones of the general formula (I) in which R1, R2, R3, R4, R5 and R6 are each as defined in the description, to processes for their preparation, to their use as herbicides and to novel intermediates and processes for preparing them.Type: GrantFiled: September 30, 2002Date of Patent: March 14, 2006Assignee: Bayer AGInventors: Karl-Heinz Linker, Kurt Findeisen, Wilhelm Haas, Markus Dollinger, Hans-Joachim Santel
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Patent number: 6984297Abstract: A method and a device are used for carrying out measurements on cells located in a liquid environment. Each cell is positioned with an underside of its membrane on a surface having a channel running through it. A negative pressure is established to aspirate the cells. Each cell is electrically scanned via at least one electrode which is spaced apart from the cell. The negative pressure is preferably established in a pulse-like manner to rupture the membrane in such a way that the cell interior enclosed by the membrane is connected to the channel.Type: GrantFiled: November 20, 2002Date of Patent: January 10, 2006Assignees: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Bayer AGInventors: Wilfried Nisch, Martin Stelzle, Alfred Stett, Thomas Krahn, Thomas Müller, Christoph Methfessel
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Patent number: 6951967Abstract: Tertiary alcohols can be prepared by the hydration of tertiary olefins having the same number of carbon atoms on an acidic ion exchanger using special structured multi-purpose packings for heterogeneous reactive rectification. An excellent yield and purity of the alcohol and an extended service life of the catalyst are achieved.Type: GrantFiled: February 13, 2003Date of Patent: October 4, 2005Assignees: EC Erdolchemie GmbH, Bayer AGInventors: Axel Gohrt, Joachim Grub, Stefan Kaminsky, Stephan Muller, Brian Schwegler
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Patent number: 6933409Abstract: Noble metal/reducible metal oxide catalysts effective for the direct amination of aromatic hydrocarbons and heterocyclic analogs thereof are disclosed. In one embodiment, the cataloxidant comprises a noble metal selected from Pd, Rh, Ir and/or Ru and a reducible metal oxide. In another embodiment, the cataloxidant comprises a noble metal and a reducible oxide of a metal selected from Ni, Mn, V, Ce, Th, Pr, Te, Re, Co, Fe, Cu and/or Bi. A preferred cataloxidant comprises one or more noble metals selected from Pd, Rh, Ir and/or Ru, in combination with nickel oxide and/or manganese oxide. In preferred applications, benzene can be aminated in the presence of the cataloxidants to form aniline. A benzene conversion of at least 5% is achieved, with more than 90% selectivity for aniline. Significantly, the cataloxidant can be regenerated without a substantial loss of performance.Type: GrantFiled: May 15, 2000Date of Patent: August 23, 2005Assignees: Symyx Technologies, Inc., Bayer AGInventors: Damodara M. Poojary, Ramesh Borade, Alfred Hagemeyer, Xiao Ping Zhou, Christopher E. Dube, Ulrich Notheis, Ralph Armbrust, Christian Rasp, David M. Lowe
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Patent number: 6923715Abstract: A device for regulating the air volume flow for a laboratory exhaust, has a rectangular housing (6) which can be arranged on the laboratory exhaust. The device is equipped with inflow devices that can be connected to the interior of the laboratory exhaust and with outflow devices (8, 12, 13) that can be connected to an exhaust air system. The interior of housing (6) is divided by a partition (17) into two parts, namely a calming part on the exhaust side and a measurement and regulating part on the outflow side, and these two parts are connected by an air deflection area (18). A rectangular measurement orifice (20, 25) has pressure measurement devices (22, 23, 24, 28, 29) and a rectangular regulating flap (21) arranged one after the other at a distance in the direction of flow between a housing wall and the partition (17).Type: GrantFiled: February 5, 2001Date of Patent: August 2, 2005Assignees: Waldner Laboreinrichtungen GmbH & Co. KG, Bayer AGInventors: Konrad Kreuzer, Frank Barth, Horst Esch