Abstract: The invention relates to a process for preparing 2,4,5-trifluoro-benzonitrile of the formula (I)
in which 2,4,5-trifluoro-aniline of the formula (II)
is, in a first step A), reacted with a nitrosating agent in the presence of a diluent and in which, in a second step B), the reaction product obtained in step A) is reacted with an alkali metal cyanide in the presence of a transition metal compound, an acid acceptor and a diluent.
Abstract: In accordance with a novel process, (R)-amines of the formula ##STR1## in which R.sup.1, R.sup.2 and n have the meanings given in the description, can be prepared by reacting reating N-acyl-amines of the formula ##STR2## in which R.sup.1, R.sup.2, R.sup.3 and n have the meanings given in the description,with lipases which are suitable for cleaving the (R)-enantiomers of N-acyl-amines of the formula (II), in the presence of water and optionally in the presence of an organic diluent, at a pH of between 3.0 and 10.0 and at temperatures of between 0.degree. C. and 80.degree. C.
Type:
Grant
Filed:
August 25, 1997
Date of Patent:
March 23, 1999
Assignee:
Bayer Aktiegesellschaft
Inventors:
Hauke Smidt, Andreas Fischer, Peter Fischer, Rolf D. Schmid, Uwe Stelzer
Abstract: For improving an adequate statement about the processing properties of granulated material to be added to unvulcanized rubber a testing device is used consisting of a support for the test sample, a wedge-shaped tool and a linearly acting pressure generator, whereby as support, bearing means for agglomerates are arranged on either side of the working plane of the movable wedge-shaped tool with bearing forces acting predominantly parallel thereto.