Patents Assigned to Bayer Aktiengellschaft
  • 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Patent number: 11130745
    Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: September 28, 2021
    Assignees: BAYER AKTIENGELLSCHAFT, BAYER PHARMA AKTIEGELLSCHAFT, THE BROAD INSTITUTE INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Stefan Nikolaus Gradl, Duy Nguyen, Knut Eis, Judith Günther, Timo Stellfeld, Andreas Janzer, Sven Christian, Thomas Müller, Sherif El Sheikh, David B. Sykes, Steven James Ferrara, Michael Kröber, Claudia Merz, Michael Niehues, Martina Schäfer, Katja Zimmermann, Carl Friedrich Nising
  • Substituted tetrahydronaphthaline and analogous compounds
    Patent number: 6586613
    Abstract: Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in this manner into the desired groups. The compounds according to the invention are suitable for use as active compounds in pharmaceuticals, in particular in pharmaceuticals for treating arteriosclerosis and also dyslipidaemias.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: July 1, 2003
    Assignee: Bayer Aktiengellschaft
    Inventors: Arndt Brandes, Michael Lögers, Jürgen Stoltefuss, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Stefan Antons, Holger Paulsen, Stephan Nicholas Müller, Paul Naab, Carsten Schmeck
  • hIL-4 mutant proteins used as antagonists or partial agonists of human interleukin 4
    Patent number: 6130318
    Abstract: The present invention relates to novel hIL-4 mutant proteins, to processes for preparing them, and to their use as medicaments, in particular in overshooting, falsely regulated immune reactions and autoimmune diseases.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: October 10, 2000
    Assignee: Bayer Aktiengellschaft
    Inventors: Hanno Wild, Rudolf Hanko, Michael Dorschug, Hans-Dietrich Horlein, Jurgen Beunink, Heiner Apeler, Hermann Wehlmann, Walter Sebald
  • Process for the preparation of polymers with repeating succinyl units using catalysts
    Patent number: 6093789
    Abstract: The invention relates to a process for preparing polymers having repeating succinyl units, especially polysuccinimide and polyaspartic acid, with increased M.sub.W values at non-increased, moderate synthesis temperatures and at the same time without increased polycondensation times, using maleic anhydride and ammonium carbonate plus a catalyst.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: July 25, 2000
    Assignee: Bayer Aktiengellschaft
    Inventors: Rudiger Schubart, Richard Weider
  • Dispersion compositions, a process for their production and their use
    Patent number: 4598120
    Abstract: The present invention is directed to aqueous dispersion compositions in the form of aqueous, spreadable coating or printing pastes, characterized in that they contain(A) aqueous dispersions of polyurethanes (Aa) or mixtures of polyurethanes (Aa) and aqueous dispersions of poly(meth)acrylates (Ab),(B) carboxyl group-containing, aqueous thickener polymer solutions,(C) self-crosslinking polyorganosiloxane mixture and(D) crosslinking agents for the polyurethanes, for the carboxyl group-containing thickener polymers (B) and, optionally, for the poly(meth)acrylates.The present invention is also directed to a process for the preparation of these aqueous dispersion compositions and to their use for coating or printing substrates.
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: July 1, 1986
    Assignee: Bayer Aktiengellschaft
    Inventors: Wilhelm Thoma, Rolf Langel, Walter Schroer