Abstract: Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to human Factor VII or human Factor VIIa, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34 or having an amino acid substitution in position 36 of the amino acid sequence shown in SEQ ID NO:1; and use of the variants for the treatment of intracerebral haemorrhage (ICH) or trauma.
Type:
Grant
Filed:
June 14, 2006
Date of Patent:
October 5, 2010
Assignee:
Bayer Healthcare LLC
Inventors:
Jesper Mortensen Haaning, Kim Vilbour Andersen, Claus Bornaes
Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, anthranilamides (group 1) and, secondly, further insecticidal active compounds selected from the group of the (thio)phosphates (group 2) and/or the group of the carbamates (group 3), which combinations are highly suitable for controlling animal pests, such as insects.
Type:
Application
Filed:
June 9, 2010
Publication date:
September 30, 2010
Applicant:
BAYER CROPSCIENCE AG
Inventors:
Christian FUNKE, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
Abstract: Novel isoxazolines of the formula (I) wherein A represents C or N; R represents haloalkyl; X represents halogen or haloalkyl; l represents 0, 1 or 2; Y represents halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, acylamino, alkoxycarbonylamino, haloalkoxycarbonyl-amino or alkylsulfonylamino; m represents 0, 1 or 2; and G represents any one selected from heterocyclic groups described in the specification; and intermediates, and a use thereof as insecticides and/or for controlling animal parasites.
Type:
Application
Filed:
August 1, 2007
Publication date:
September 30, 2010
Applicant:
Bayer Cropscience SA
Inventors:
Pierre-Yves Coqueron, Marie-Claire Grosjean-Cournoyer, Philippe Desbordes, Pierre Genix, Benoit Hartmann, Amos Mattes, Klaus Kunz, Rudiger Fischer, Oliver Gaertzen, Oswald Ort, Darren Mansfield, Alain Villier
Abstract: The invention relates to a metal matrix material made of a hydrogen-permeable metal 1 and a chemically stable metal 2 that is also hydrogen permeable, said matrix material having a structure comprised of a plurality of centers made of the metal 2 surrounded by the metal 1. The invention further relates to a method for the production of said matrix material, having the following steps: a. optionally pretreating the metal 1 and/or 2 b. coating metal 1 with a metal 2 to form a composite metal powder c. pressing the composite metal powder into the metal matrix material according to the invention in the form of a pressed body d. optionally deforming the pressed body thus obtained to form a molded body. The metal matrix material has a greater mechanical stability as compared to a conventionally coated metal film by virtue of a more homogeneous stress distribution during the change in volume of the metal phases as a result of hydrogen absorption and thermal expansion.
Type:
Application
Filed:
September 9, 2008
Publication date:
September 30, 2010
Applicant:
BAYER TECHNOLOGY SERVICES GMBH
Inventors:
Leslaw Mleczko, Juergen Kintrup, Ralph Weber, Andre Dammann, Rafael Warsitz, Aurel Wolf
Abstract: The present invention is related to a method for identifying an interaction partner of an active agent, comprising the following steps: (a) providing an element library comprising a plurality of elements, (b) contacting the element library with a preparation comprising an interaction partner under conditions allowing for formation of a complex consisting of a binding element of the element library binding to the interaction partner and the interaction partner, whereupon a complex comprising the binding element and the interaction partner is formed, (c) removing non-binding elements of the element library from the complex formed in step (b), (d) contacting the complex formed in step (b) with the active agent, whereby the binding element is released from said complex, (e) contacting the binding element released in step (d) with a preparation comprising the interaction partner, whereupon a complex is formed comprising the binding element released in step (d) and the interaction partner, and (f) characterising
Abstract: The invention relates to the novel use of known active substance combinations which consist firstly of 3,4-dichloro-2?-cyano-1,2-thiazole-5-carboxanilide, of the formula which is known, and secondly further known insecticidal active substances, for controlling animal pests, especially arthropods, in particular insects.
Type:
Application
Filed:
November 27, 2008
Publication date:
September 30, 2010
Applicant:
Bayer CropScience AG
Inventors:
Lutz Assmann, Ulrike Wachendorff-Neumann, Heike Hungenberg, Wolfgang Thielert
Abstract: The present invention relates to a segmented roof for a motor vehicle comprising a plurality of segments which are connected to one another in a cohesively bonded and/or interlocking manner, are guided laterally in guide rails by means of pins and are movable between a closed position, in which the segments are closely contiguous to one another, and an open position, in which the segments are pushed together and folded in a roof region, characterized in that, apart from the last segment [10], each segment [8] has two opposite sides A and two opposite sides B, and the segments are connected to one another along the sides B, and each side A has two pins [4], [5], one subset of the pins [4] being differently dimensioned from the other subset of the pins [5], two pins located on one side A being differently dimensioned, and two opposite pins on the opposite sides A of a segment each being identically dimensioned.
Type:
Application
Filed:
October 7, 2008
Publication date:
September 30, 2010
Applicant:
Bayer Material/Science AG
Inventors:
Florian Dorin, Stephan Lange, Roland Brambrink, Ulrich Grosser
Abstract: The present invention relates to the use of wheat flour for reducing baking losses. The wheat flour can comprise genetically or chemically phosphorylated starch.
Abstract: An optical waveguiding optical format enables consistent optical analysis of small sample volumes with minimal variation in light path length among optical formats. The optical format is comprised of an input guide, an output guide, and a sample cavity adapted to allow light to pass through a sample on its way from the input guide to the output guide. A lid removed from the light pathway within the format may be provided with a reagent for assisting fluid analysis.
Abstract: The present invention relates to flame-protected impact-modified polycarbonate compositions, wherein the compositions are free of rubber-free polyalkyl (alkyl)acrylate. The present invention further relates to the use of the polycarbonate compositions in the production of moulded bodies, and to the moulded bodies themselves.
Type:
Application
Filed:
March 23, 2010
Publication date:
September 30, 2010
Applicant:
BAYER MATERIAL SCIENCE AG
Inventors:
Achim FELDERMANN, Thomas Eckel, Andreas Seidel, Dieter Wittmann
Abstract: The invention relates to a vehicle roof which comprises an opening, a foldable arrangement (3) and a device for accommodating said foldable arrangement (3), the foldable arrangement (3) comprising at least two parallel plastic segments (1). The foldable arrangement (3) can be transferred to a corresponding device (4) while being folded, thereby at least partly releasing the opening, and the foldable arrangement (3) completely closes the opening in the closed position. The segments (1), when in the closed position, are curved due to deformation and are substantially flat and plane-parallel when at least partly releasing the opening.
Type:
Application
Filed:
October 7, 2008
Publication date:
September 30, 2010
Applicant:
BAYER MATERIALSCIENCE AG
Inventors:
Florian Dorin, Stephan Lange, Roland Brambrink, Ulrich Grosser
Abstract: This invention relates to transgenic winter oilseed rape (WOSR) plants, plant material and seeds, harboring a specific transformation event. It pertains to winter oilseed rape plants, more particularly to a pair of winter oilseed rape plants, which is particularly suited for the production of hybrid seed. More specifically, one plant is characterized by being male-sterile, due to the presence in its genome of a male sterility gene, while the other is characterized by carrying a fertility-restorer gene, capable of preventing the activity of the male-sterility gene. The invention further provides a method for producing hybrid seed, a process for producing a transgenic WOSR plant oil or plant, and a method to identify a transgenic plant, cell or tissue. A kit for identifying the transgenic plants comparing the elite event of the present invention is also described.
Abstract: This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
Inventors:
Stephen Boyer, Michael Härter, Philip L. Wickens, Manoj Patel, Ellalahewage Sathyajith Kumarasinghe, Ajay Kumar Bhargava, Karl-Heinz Thierauch, Hartmut Beck, Susanne Greschat, Peter Ellinghaus, Patrick Paulus, Holger Hess-Stumpp
Abstract: The present invention relates to novel active ingredient combinations which consist of fluopyram and further known active insecticidal ingredients, and are very suitable for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in seed treatment.
Abstract: The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for their preparation and to their use as intermediates in the synthesis of insecticidal, acaricidal and herbicidal compounds or pharmaceutically active compounds.
Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
Type:
Grant
Filed:
May 22, 2009
Date of Patent:
September 28, 2010
Assignee:
Bayer Pharmaceuticals Corporation
Inventors:
Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin F. Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips