Abstract: The invention relates to an optical measurement probe for process monitoring, having a distal end, arranged in the region of a process apparatus, with a light entrance opening, and a proximal end coupled to a spectrometer, wherein a shaft comprising a light-guiding connection between the distal and proximal ends of the measurement probe is arranged between the two ends. The measurement probe is characterized in that the measurement probe has, in its distal region relative to the shaft and/or the proximal end, a reduced external diameter (FIG. 1).

Abstract: The invention relates to a semi-continuous chromatographic method for the separation of binary and multi-component mixtures and corresponding devices.

Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.

Abstract: Sampling valve with which samples containing mechanically sensitive material are removed in a sterile manner from a bioreactor, and process analysis system with analysis stations, in particular chromatography systems, biosensors and cell determination devices, permitting automated, sterile removal of a sample from a bioreactor and gentle transport of the sample, containing mechanically sensitive material, in particular cells, to the analysis station

Abstract: Novel seed dressing agent formulations comprising of—at least one active agrochemical ingredient for the dressing of seeds, —a dispersion of biologically degradable polyester-polyurethane-polyureas in water whereby the solid content thereof is between 30 and 50 weight %. Said formulation also comprises additives. The invention also relates to a method for the production of a novel seed dressing agent formulation and the utilization thereof for the dressing of seeds.

Abstract: A method for the ultrasensitive simultaneous measurement of nonlinear optical emission signals in one or two local dimensions wherein excitation light is irradiated in modulated form from at least one light source into an interactive space in which one or several emissions that are nonlinearly correlated with the excitement light can be excited. The light emanating from the interactive spaces is measured using a one or two-dimensional detector array. Measured data is then transmitted to a computer and formatted in a one or two-dimensional data matrix. Further, non-correlated portions of the light emanating from the interactive spaces that are linearly proportionate to the intensity of the excitement light available in the interactive spaces are separated from portions of the light emanating from the interactive spaces which are not linearly proportionate. The invention also relates to an analytical system for carrying out this method.

Abstract: Computer system for calculating a pharmacokinetic behavior of a chemical substance in insects, comprising: a physiologically based pharmacokinetic simulation model (102) of an insect for predicting concentration/time profiles of the chemical substance in compartments of the insect, the simulation model having at least one parameter which is dependent on the substance, and a prediction module (110) for predicting the at least one parameter on the basis of a physicochemical property of the substance.

Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups.

Abstract: The present invention relates to a process and an apparatus for preparing aromatic amines by means of a heterogeneously catalysed hydrogenation, wherein the catalyst required for the reaction is applied to the interior wall of one or more reaction channels which are cooled from the outside.

Abstract: The invention relates to a method for developing a biomarker for the prognosis of the result of a therapeutical treatment based on data obtained in clinical studies, data remaining unchanged by therapy being subdivided into diagnostic and genomic parameters and the marker being defined by a combination of parameters. The method according to the invention is characterized by specifying the maximum number of parameters for defining the marker and thus the maximum complexity of the system from the beginning and by carrying out the search for defining parameters by sequential combination of clinical parameters (=z parameters) and/or genomic parameters (=x parameters).

Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.

Abstract: The present invention relates to a method for etching carbon fibers, in particular carbon nanofibers and to the carbon nanofibres obtainable by this method, and the use thereof.

Abstract: A process and an apparatus for the bubble-free production of gas into liquids, in particular in biotechnology and especially of cell cultures, with gas exchange via one or more immersed membrane surfaces of any type (tubes, cylinders, etc.), with the membrane surfaces in rotary oscillating motion in the liquid.

Abstract: The present invention relates to a process and an apparatus for preparing chlorine by gas-phase oxidation of hydrogen chloride by means of an oxygen-containing gas stream, wherein the catalyst required for the reaction is applied to the interior wall of one or more externally cooled reaction channels.

Abstract: The invention relates to cleanable spiral modules and a method for production thereof.

Abstract: The present invention relates to a method for removing volatile compounds from sparingly volatile fluids by means of rectification using an auxiliary and also to separation methods and chemical reactions in which sparingly volatile fluids are used, the purification of which is effected by means of rectification and using an auxiliary.

Abstract: The invention relates to a catalytically active membrane pore flow reactor, to the membrane used and to processes using this reactor.

Abstract: Heatable filter plate comprising two interconnected corrugated elements forming a cavity for the flow of a temperature controlled medium, filter press comprising said filter plate and diaphragm-filter plates in an alternating manner, and method for drying filter cakes in said filter press.

Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.

Abstract: Method and system for designing experiments by selecting at least a first experiment from an experimental space using a data-driven optimizer, receiving experimentally determined data, evaluating the experimentally determined data at a mata layer module, processing the experimentally determined data at the optimizer; the processing at the optimizer being influenced by the evaluation data.