Patents Assigned to Baylor College of Medicine
  • TUNING BIOLOGICAL SYSTEM PROPERTIES FOR OPTIMIZED TREATMENT EFFICACY
    Publication number: 20160263150
    Abstract: Various embodiments of the present disclosure pertain to methods of optimizing a treatment efficacy of a biological system by tuning a property of the biological system through the addition of an optimizing agent to the biological system. The tuning can include: (a) determining a property parameter of the biological system; (b) selecting an optimizing agent to be added to the biological system based on the determined property parameter; and (c) adding the optimizing agent to the biological system. The optimizing agent can include a kosmotropic material. The biological system can include a tissue, such as a tumor. The methods of the present disclosure can be utilized to enhance the efficacy of various treatments, such as the heat treatment of a biological system exposed to a radiofrequency field. The methods of the present disclosure can also include a step of treating the biological system.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 15, 2016
    Applicants: Baylor College of Medicine, William Marsh Rice University
    Inventors: Nadia C. Lara, Andrew R. Barron, Stuart Corr, Steven Curley
  • SEPARASE INHIBITORS AND USES THEREOF
    Publication number: 20160250191
    Abstract: In some embodiments, the present disclosure pertains to compositions with compounds that inhibit Separase activity. In additional embodiments, the present disclosure pertains to methods of treating a tumor in a subject by administering one or more compositions of the present disclosure to the subject.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 1, 2016
    Applicant: Baylor College of Medicine
    Inventors: Debananda Pati, Nenggang Zhang
  • Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
    Patent number: 9428569
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: August 30, 2016
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: David Spencer, Priyadharshini Narayanan
  • Methods for inducing selective apoptosis
    Patent number: 9393292
    Abstract: Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: July 19, 2016
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventor: Malcolm K. Brenner
  • INTENTION DETECTION IN DOMAIN-SPECIFIC INFORMATION
    Publication number: 20160203118
    Abstract: A new information in a language and relating to a subject matter domain is parsed into a constituent set of complete grammatical constructs. In a subset of the complete grammatical constructs, a set of linguistic styles of the language is identified according to a subset of a set of word-style associations related to the language and independent of the subject matter domain. A first weight is assigned to a first linguistic style and a second weight to a second linguistic style from the set of linguistic styles. A first intention information is mapped to the first style using a first style-intention rule, and a second intention information to the second style using a second style-intention rule. A complete grammatical construct in the subset is tagged with the first intention information responsive to a weight associated with the first intention information exceeding an intention selection threshold.
    Type: Application
    Filed: March 16, 2016
    Publication date: July 14, 2016
    Applicants: International Business Machines Corporation, Baylor College of Medicine, The Board of Regents, The University of Texas System
    Inventors: Meenakshi Nagarajan, William Scott Spangler, Benjamin J. Bachman, Lawrence A. Donehower, Olivier Lichtarge, Sam J. Regenbogen, Angela D. Wilkins, Curtis R. Pickering
  • NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT
    Publication number: 20160168185
    Abstract: A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R1 is H, methyl, or benzyl; R2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if X=S, R2=O; Y is C3 or C4; Z1 is O, S, N, or CH2; and Z2 is N or CR4, wherein R4 is a halogen, alkyl, aryl or a 5- or 6-membered heterocycle; and wherein said compound is selective for DOT1L Methyl Transferase.
    Type: Application
    Filed: July 22, 2014
    Publication date: June 16, 2016
    Applicant: Baylor College of Medicine
    Inventors: Yongcheng SONG, Lisheng DENG, Yang YAO, Li ZHANG, Cong WANG, Michele S. REDELL, Shuo DONG
  • EVENT DETECTION USING ROLES AND RELATIONSHIPS OF ENTITIES
    Publication number: 20160162788
    Abstract: A method, system, and computer program product for event detection using roles and relationships of entities are provided in the illustrative embodiments. A training event and a set of entities participating in the training event are identified in a training data. For a first entity in the set of entities, a first role occupied by the entity in the event is determined. A behavior attribute is assigned to the first role. A relationship of the first role with a second role corresponding to a second entity in the set of entities is determined. An event rule is constructed to detect an event corresponding to the training event in new data and comprising a plurality of roles, behavior attributes, and the relationship. The plurality of roles includes the first role and the second role, and the plurality of behavior attributes includes the behavior attribute assigned to the first role.
    Type: Application
    Filed: December 8, 2014
    Publication date: June 9, 2016
    Applicants: International Business Machines Corporation, Baylor College of Medicine, The Board of Regents, The University of Texas System
    Inventors: Ying Chen, Linda H. Kato, Jacques J. Labrie, Meenakshi Nagarajan, William Scott Spangler, Ioana R. Stanoi, Anbu Karani Adikesavan, Benjamin J. Bachman, Lawrence A. Donehower, Olivier Lichtarge, Sam J. Regenbogen, Maria E. Terron-Diaz, Angela D. Wilkins, Curtis R. Pickering
  • INTENTION DETECTION IN DOMAIN-SPECIFIC INFORMATION
    Publication number: 20160162465
    Abstract: A new information in a language and relating to a subject matter domain is parsed into a constituent set of complete grammatical constructs. In a subset of the complete grammatical constructs, a set of linguistic styles of the language is identified according to a subset of a set of word-style associations related to the language and independent of the subject matter domain. A first weight is assigned to a first linguistic style and a second weight to a second linguistic style from the set of linguistic styles. A first intention information is mapped to the first style using a first style-intention rule, and a second intention information to the second style using a second style-intention rule. A complete grammatical construct in the subset is tagged with the first intention information responsive to a weight associated with the first intention information exceeding an intention selection threshold.
    Type: Application
    Filed: December 8, 2014
    Publication date: June 9, 2016
    Applicants: International Business Machines Corporation, Baylor College of Medicine, The Board of Regents, The University of Texas System
    Inventors: MEENAKSHI NAGARAJAN, William Scott Spangler, Benjamin J. Bachman, Lawrence A. Donehower, Olivier Lichtarge, Sam J. Regenbogen, Angela D. Wilkins, Curtis R. Pickering
  • STAT6 INHIBITORS
    Publication number: 20160145279
    Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.
    Type: Application
    Filed: May 8, 2014
    Publication date: May 26, 2016
    Applicants: Baylor College of Medicine, Board of Regents, The University of Texas System
    Inventors: John S. McMURRAY, Pijus Kumar MANDAL, Pietro MORLACCHI, Morgan KNIGHT, David B. CORRY
  • Methods and Compositions for the Treatment of Cancer and Related Hyperproliferative Disorders
    Publication number: 20160136164
    Abstract: The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B—C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.
    Type: Application
    Filed: November 13, 2015
    Publication date: May 19, 2016
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Motonari Uesugi, Salih J. Wakil, Lutfi Abu-Elheiga, Mizuki Watanabe
  • PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY
    Publication number: 20160136289
    Abstract: Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity.
    Type: Application
    Filed: July 9, 2014
    Publication date: May 19, 2016
    Applicants: The USA, as represented by the Secretary, Department of Health and Human Services, Baylor College of Medicine
    Inventors: Anu Puri, Robert P. Blumenthal, Amit Joshi, Darayash B. Tata
  • Methods and Compositions for the Treatment of Body Weight Related Disorders
    Publication number: 20160128985
    Abstract: The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described.
    Type: Application
    Filed: January 8, 2016
    Publication date: May 12, 2016
    Applicant: Baylor College of Medicine
    Inventors: Motonari Uesugi, Salih J. Wakil, Lutfi Abu-Elheiga, Mizuki Watanabe
  • Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
    Patent number: 9315559
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: April 19, 2016
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: David Spencer, Priyadharshini Narayanan
  • Male contraceptive compositions and methods of use
    Patent number: 9301962
    Abstract: The invention relates to compositions and methods for effecting male contraception.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: April 5, 2016
    Assignees: Baylor College of Medicine, Dana Farber Cancer Institute, Inc.
    Inventors: James Elliott Bradner, Martin Matzuk, Jun Qi
  • Supercoiled minicircle DNA for gene therapy applications
    Patent number: 9267150
    Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid sequence.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: February 23, 2016
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, Jr., Erol Bakkalbasi, Brian E. Gilbert
  • vaccine and antibody for prevention and treatment of human, animal and cell culture infection
    Patent number: 9241983
    Abstract: The present invention encompasses methods and compositions for Ureaplasma infection prevention and/or treatment. In specific cases, the invention concerns vaccines for Ureaplasma, including DNA vaccines. In certain embodiments, the invention regards vaccines directed towards the multiple-banded antigen(s) of Ureaplasma.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 26, 2016
    Assignee: Baylor College of Medicine
    Inventors: Leonard Weisman, Lingkun Kong
  • Methods and compositions for the treatment of body weight related disorders
    Patent number: 9233941
    Abstract: The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: January 12, 2016
    Assignee: Baylor College of Medicine
    Inventors: Motonari Uesugi, Salih J. Wakil, Lutfi Abu-Elheiga, Mizuki Watanabe
  • SUPERCOILED MINIVECTORS AS A TOOL FOR DNA REPAIR, ALTERATION AND REPLACEMENT
    Publication number: 20150376645
    Abstract: In some embodiments the present disclosure provides a composition for targeted alteration of a DNA sequence and methods of altering the targeted DNA sequence using the composition. In some embodiments such a composition comprises a MiniVector comprising a nucleic acid sequence template for homology-directed repair, alteration, or replacement of the targeted DNA sequence within a cell in vivo or in vitro, where the MiniVector lacks both a bacterial origin of replication and an antibiotic selection gene, and wherein the Mini Vector has a size up to about 2,500 base pairs.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 31, 2015
    Applicants: BAYLOR COLLEGE OF MEDICINE, UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, JR., Nancy Maizel, Olivier Humbert
  • System and method for evaluating ocular health
    Patent number: 9220405
    Abstract: A method for adaptively determining a model of visual performance of a test subject comprising the step of exposing a test subject to a plurality of trials. Each trial comprises the steps of identifying the stimulus pattern to test, generating a stimulus pattern on a display, determining whether the stimulus pattern generated an OKR, updating the model to incorporate the OKR results, and determining whether the updated model is acceptable. The trials can be iteratively repeated until the model for visual performance is acceptable.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: December 29, 2015
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Benjamin J. Frankfort, Cameron S. Cowan, Samuel Miao-sin Wu
  • METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF
    Publication number: 20150359765
    Abstract: A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a salt thereof, for example phenylbutyrate or an even numbered congener thereof or a salt thereof, is administered to an individual in need thereof. In various methods, a decrease in plasma levels of branched chain amino acids and branched chain alpha-keto acids is effected to treat individuals suffering from an inborn error in metabolism of amino acids, such as Maple Syrup Urine Disease, for example.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 17, 2015
    Applicant: Baylor College of Medicine
    Inventor: Brendan Lee