Abstract: Provided herein are biomolecular hybridization devices comprising a substrate with a permanently and covalently attached surface of functional groups and an adsorbed monolayer of unmodified, single-stranded oligonucleotides all of which are 10 to about 24 bases in length as a saturated film of constrained oligonucleotides on the surface via direct non-covalent phosphate-surface adsorptive contact of substantially all phosphate groups of each oligonucleotide. The constrained oligonucleotides are effective to dissociably hybridize to a complementary single-stranded nucleic acid with asymmetric, non-helical base pairing and without oligonucleotide dissociation from the surface of the device. Also, provided are methods for hybridizing solution-state target nucleic acids to probe nucleic acids and for identifying a nucleotide sequence to which a nucleotide-binding protein binds using the biomolecular hybridization devices.

Abstract: A method and computer system for identifying genes associated with a phenotype includes obtaining data representing mutations in a cohort of subjects exhibiting a phenotype. An evolutionary action (EA) score is calculated for each mutation using the data obtained. For each gene in the cohort, respective distributions of the calculated EA scores are determined for mutations found in the gene. The determined distributions of EA scores are quantitatively compared within the cohort and with random distributions to establish comparison data. Based on the comparison data, distributions of EA scores are identified that are non-random, and linkage of each gene in the cohort to the phenotype is assessed based on the identified non-random distributions to identify genes associated with the phenotype. The phenotype can be a disease, such as cancer, and linkage of each gene in the cohort to the disease can be assessed to identify disease causing genes.

Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

Abstract: Systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: The invention offers high resolution and accuracy for nanoscale temperature mapping. Instead of collecting light after emission in near-field that decays to far-field, the present invention directly couples the near-field waves to a polaritonic-coated infrared probe. The polaritonic coating can be formed on an IR-tuned optical fiber to receive the coupled IR radiation and form polaritons, including plasmons or phonons, using the IR polaritonic material. The IR polaritons propagate along the probe decay back into the fiber core without substantial losses to far-field and are transmitted to a detector, such as a spectroscope. The coupling of the near-field energy to emission detected through the tip apex of fiber can be expressed as emission spectra. Through mapping with other spatial points, multi-dimensional displays and other information can be provided. The resolution can be less than 100 nanometers, such as at least an order of magnitude less than 100 nanometers.

Abstract: Force sensing may be integrated with a laryngoscope and information conveyed to the user when an applied force in a patient's mouth may cause dental trauma. By warning the user, the user may be interrupted before dental trauma occurs, allowing the user to adjust the procedure.

Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.

Abstract: Methods and compositions are provided for inhibiting, preventing, ameliorating and/or reducing damage to DNA in non-cancerous cells in a subject undergoing chemotherapeutic treatment and/or radiation treatment of cancer cells in the subject, comprising administering to the subject one or more compounds of arsenic in a therapeutically effective amount prior to chemotherapeutic treatment and/or radiation treatment.

Abstract: The present disclosure provides a system and method for an ultrathin optical metasurface with an array patterning formed on an optical fiber facet that enables manipulation of light passing therethrough, such as focusing and steering the light, and controlling a polarization state of light. The patterning can be non-uniform to selectively direct light passing through the metasurface. Array structures can vary in size, angle, shapes, and other non-uniform aspects. Further, the array can include materials that can be electrically activated and controlled to variably tune the metasurface characteristics for increased ability to manipulate the light passing therethrough. The materials can include a conductor, a dielectric, or a composite of a conductor, insulator, and dielectric formed on the optical fiber.

Abstract: The present disclosure provides a low-cost and accurate rheometer system and method capable of determining melt flow rheological properties of polymers, such as from Fused Filament Fabrication (“FFF”) polymeric materials. The device can include a filament feeding system, liquefier for filament melting, force transducer for measuring filament feeding force, and a temperature control system for controlling polymer melt temperatures. An electronic control system can capture data and manage operations. The system can measure a filament velocity and filament force required to extrude the FFF filament for printing. The filament velocity and force data can be used to compute data sets of melt volumetric flow relative to pressure drop across a FFF nozzle.

Abstract: Methods for the ex vivo modification of the surfaces of viable tissue result in tissue modifications that are stable and/or result in the controlled release of active compounds, and are expected to provide effective protection for transplanted tissue subsequent to transplant.

Abstract: Method and system are disclosed for characterizing and quantifying composite laminate structures. The method and system take a composite laminate of unknown ply stack composition and sequence and determine various information about the individual plies, such as ply stack, orientation, microstructure, and type. The method and system can distinguish between weave types that may exhibit similar planar stiffness behaviors, but would produce different failure mechanisms. Individual ply information may then be used to derive the laminate bulk properties from externally provided constitutive properties of the fiber and matrix, including extensional stiffness, bending-extension coupling stiffness, bending stiffness, and the like. The laminate bulk properties may then be used to generate a probabilistic failure envelope for the composite laminate.

Abstract: A series of benzosuberene analogues demonstrate effective inhibition of tubulin polymerization, cytotoxicity against human cancer cell lines, and vascular disruption in tumors.

Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: A magnet assisted surgical device, system, and method employs magnetic sections, catheters, and guidewires to modify tubular stentgrafts in-situ. One example application provides a more reliable way for surgeons to modify stentgrafts insitu to allow blood flow to continue to branching blood vessels that would otherwise be blocked by the stentgraft itself. One such method includes placing a tip section of the device in the desired location, deploying a stentgraft, placing a magnetic device inside the stentgraft, connecting the magnetic device to the tip section, and excising the portion of the stentgraft held between the magnet and the tip section.

Abstract: Disclosed virtual wireless networks include a network controller interconnected with wireless access points by a broadband backbone. The controller may include or interface with a gateway coupling the virtual network to the Internet via one or more interim networks. The broadband backbone includes network switches and broadband interconnects interconnecting the wireless access points and the network controller. The broadband backbone may be implemented as an optical backbone and the broadband interconnects may include one or more optical fiber interconnects. The network controller may control the manner in which mobile devices connect to wireless access points. The network controller may configure the wireless access points to present, to mobile devices within the isolated environment, the plurality of physical wireless cells provided by the plurality of individual wireless access points as a single virtual wireless network.

Abstract: Embodiments of the disclosure include methods and compositions related to immunotherapy that targets CD5. In particular embodiments, immune cells engineered to comprise a chimeric antigen receptor (CAR) that targets CD5 are contemplated, and uses thereof. In particular embodiments, the immune cells expressing the CAR do not commit fratricide to any great extent against T cells that express CD5 and which are endogenous to an individual receiving the immune cells.

Abstract: Systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: Methods for generating/expanding populations of immune cells comprising immune cells specific for an Epstein Barr Virus (EBV) lytic antigen are disclosed, the methods comprising stimulating immune cells specific for an EBV lytic antigen by contacting peripheral blood mononuclear cells (PBMCs) with: (i) one or more peptides corresponding to all or part of one or more EBV lytic antigens; or (ii) antigen presenting cells (APCs) presenting one or more peptides corresponding to all or part of one or more EBV lytic antigens. Also disclosed are populations of immune cells comprising immune cells specific for an EBV lytic antigen expanded according to such methods, and uses thereof.

Abstract: The present disclosure provides an optical waveguide design of a fiber modified with a thin layer of epsilon-near-zero (ENZ) material. The design results in an excitation of a highly confined waveguide mode in the fiber near the wavelength where permittivity of thin layer approaches zero. Due to the high field confinement within thin layer, the ENZ mode can be characterized by a peak in modal loss of the hybrid waveguide. Results show that such in-fiber excitation of ENZ mode is due to the coupling of the guided fundamental core mode to the thin-film ENZ mode. The phase matching wavelength, where the coupling takes place, varies depending on the refractive index of the constituents. These ENZ nanostructured optical fibers have many potential applications, for example, in ENZ nonlinear and magneto-optics, as in-fiber wavelength-dependent filters, and as subwavelength fluid channel for optical and bio-photonic sensing.