Patents Assigned to Baylor
  • Fatty Acid Nutritional Supplement
    Publication number: 20100222428
    Abstract: A seven-carbon fatty acid or derivative thereof has been identified as an excellent energy source for humans or human infants. A nutritional supplement suitable for humans or human infants comprising a seven carbon fatty acid chain compound or derivative thereof can be used to increase energy production derived from fatty acid metabolism. For example, administering a seven carbon fatty acid chain compound or derivative thereof can be used to accelerate the growth rate of a prematurely born human infant.
    Type: Application
    Filed: March 8, 2010
    Publication date: September 2, 2010
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventor: Charles R. Roe
  • Multivariable antigens complexed with targeting humanized monoclonal antibody
    Patent number: 7786267
    Abstract: The present invention includes compositions and methods for designing, making and using modular recombinant antibodies or fragments thereof with one half of a cohesin-dockerin pair that permits the rapid assembly of multivariant antigen conjugates.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: August 31, 2010
    Assignee: Baylor Research Institute
    Inventors: Gerard Zurawski, Anne-Laure Flamar, Eynav Klechevsky
  • Diagnostic Methods for HIV Infection
    Publication number: 20100216119
    Abstract: The invention relates to a method of aiding the diagnosis of a human immunodeficiency virus infection in a subject, said method comprising (i) providing a sample from the subject (ii) determining the level of ps20 in said sample (iii) comparing the level of ps20 of (ii) with the level of ps20 in an uninfected reference sample, wherein a higher level of ps20 in the sample from the subject compared to the uninfected reference sample indicates an increased likelihood of human immunodeficiency virus infection in said subject. The invention also relates to methods for assessing susceptibility of a subject to human immunodeficiency virus infection. Most suitably the ps20 level is determined via binding by an anti-ps20 antibody such as the 107 antibody. The invention also relates to kits for use in said methods.
    Type: Application
    Filed: October 15, 2008
    Publication date: August 26, 2010
    Applicants: KING'S COLLEGE LONDON, BAYLOR COLLEGE OF MEDICINE
    Inventors: Annapurna Vyakarnam, David R. Rowley
  • METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS
    Publication number: 20100203067
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
    Type: Application
    Filed: September 21, 2009
    Publication date: August 12, 2010
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: David Spencer, Narayanan Priyadharshini
  • FRUCTOSE 1, 6 BISPHOSPHATE - A NOVEL ANTICONVULSANT DRUG
    Publication number: 20100197610
    Abstract: The present invention concerns methods and compositions for preventing one or more epileptic seizures in an individual by delivering fructose-1,6-bisphosphate to the individual. In certain cases, an additional therapy for epilepsy is provided to the individual.
    Type: Application
    Filed: January 23, 2008
    Publication date: August 5, 2010
    Applicant: Baylor College of Medicine
    Inventors: Xiao-Yuan Lian, Janet L. Stringer
  • Method for Increasing CD8+ Cytotoxic T Cell Responses and for Treating Multiple Sclerosis
    Publication number: 20100183546
    Abstract: The present invention relates generally to the field of immunology and development of autologous vaccines. More specifically, the present invention is concerned with a method of treating autoimmune disease Multiple Sclerosis (MS) by means of immunizing patients with autologous CD8+ cells activated with fragments of Myelin Basic Protein (MBP). The present invention identifies four immunogenic MBP fragments with high binding affinity to HLA-A2 and HLA-A24 receptors and discloses how to use these fragments in preparing anti-MS vaccine.
    Type: Application
    Filed: December 3, 2009
    Publication date: July 22, 2010
    Applicant: Baylor College of Medicine
    Inventor: Ying C. Q. Zang
  • Fatty acid nutritional supplement
    Patent number: 7754764
    Abstract: A seven-carbon fatty acid or derivative thereof has been identified as an excellent energy source for humans or human infants. A nutritional supplement suitable for humans or human infants comprising a seven carbon fatty acid chain compound or derivative thereof can be used to increase energy production derived from fatty acid metabolism. For example, administering a seven carbon fatty acid chain compound or derivative thereof can be used to accelerate the growth rate of a prematurely born human infant.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 13, 2010
    Assignee: Baylor Research Institute
    Inventor: Charles R. Roe
  • LARGE SCALE PANCREATIC ISLET PURIFICATION
    Publication number: 20100166718
    Abstract: The present invention includes a method of isolating pancreatic islets by density centrifugation wherein the pancreatic islets are loaded in a solution comprising pancreatic islets with the density gradient and the islets are isolated by centrifuging the vessel wherein the pressure on the pancreatic islets is less than 50 Pa and wherein the pancreatic islets are isolated from the gradient, the improvement comprising creating a continuous density gradient in a vessel comprising at least 100 milliliters with a bend tube that reduces convection currents that disrupt the gradient.
    Type: Application
    Filed: December 23, 2009
    Publication date: July 1, 2010
    Applicant: Baylor Research Institute
    Inventors: Shinichi Matsumoto, Masayuki Shimoda
  • APPARATUS AND METHOD FOR THE PRESERVATION OF PANCREATIC TISSUE AND ISLET CELLS FOR TRANSPLANTATION
    Publication number: 20100167259
    Abstract: The present invention includes compositions and methods for the preparation, preservation and storage of organs (e.g., pancreatic islet cells) for transplantation by storing organs in which the organs are suspended in a solution for maintaining viability and the organ or cells are cooled in a refrigeration unit for the entire duration of storage in which the average temperature in the apparatus does not vary by more than 2 degrees centigrade from the set temperature.
    Type: Application
    Filed: December 23, 2009
    Publication date: July 1, 2010
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: Shinichi Matsumoto, Tetsuya Ikemoto
  • T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same
    Patent number: 7744893
    Abstract: The present invention relates generally to the field of treating and monitoring multiple sclerosis by utilizing T-cell receptors peptides. In particular, nucleic acids and peptide sequences of T-cell receptors found in a population of MS patients are provided, along with compositions comprising such TCR peptides for use in, e.g., vaccines.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: June 29, 2010
    Assignees: Baylor College of Medicine, Opexa Pharmaceuticals, Inc.
    Inventor: Jingwu Z. Zhang
  • FIG4 GENE MUTATIONS IN NEURODEGENERATION
    Publication number: 20100143255
    Abstract: The present invention relates to neuropathy, in particular to mutations in the FI G4 gene. The present invention also provides assays for the detection of variant FIG4 alleles, and assays for detecting FIG4 polymorphisms and mutations associated with disease states.
    Type: Application
    Filed: April 25, 2008
    Publication date: June 10, 2010
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, BAYLOR COLLEGE OF MEDICINE
    Inventors: Miriam Meisler, James R. Lupski, Clement Chow
  • HIV VACCINE BASED ON TARGETING MAXIMIZED GAG AND NEF TO DENDRITIC CELLS
    Publication number: 20100135994
    Abstract: The present invention includes compositions and methods for making and using a vaccine that includes a DC-specific antibody or fragment thereof to which an engineered Gag antigen is attached to form an antibody-antigen complex, wherein the Gag antigen is less susceptible to proteolytic degradation by eliminating one or more proteolytic sites or a DC-specific antibody or fragment thereof to which an engineered Nef antigen is attached to form an antibody-antigen complex, wherein the Nef antigen comprises one or more codon usage optimization that increase antibody-antigen complex secretion, or both, wherein the vaccine is able to elicit an HIV-specific T cell immune response to Gag p17, Gag p24, Nef and/or Cyclin D1.
    Type: Application
    Filed: July 16, 2009
    Publication date: June 3, 2010
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: Jacques F. Banchereau, Gerard Zurawski, Anne-Laure Flamar, Amanda Cobb, Holly Mead, Monica Montes
  • RTVP-GliPR-like compositions and methods for the detection, treatment and prevention of prostate cancer
    Patent number: 7723475
    Abstract: The invention is directed to purified and isolated novel RGL2 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: May 25, 2010
    Assignee: Baylor College of Medicine
    Inventors: Timothy C. Thompson, Chenghui Ren, Chengzhen Ren
  • SYSTEMIC LUPUS ERYTHEMATOSUS DIAGNOSTIC ASSAY
    Publication number: 20100113293
    Abstract: The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile of a suitable sample by screening for the presence of a differentially expressed SLE-associated gene isolated from a sample containing or suspected of containing a cell that can differentially express an SLE-associated gene.
    Type: Application
    Filed: September 11, 2009
    Publication date: May 6, 2010
    Applicant: BAYLOR RESEARCH INSTITUTE
    Inventors: Maria Virginia Pascual, Jacques F. Banchereau, Lynda B. Bennett
  • Random access high-speed confocal microscope
    Patent number: 7706584
    Abstract: Disclosed herein is a confocal imaging system for imaging a specimen. The system comprises a light source, a light deflector capable of positioning a beam of light produced by the light source at one of a series of predetermined points on the specimen, an addressable spatial filter capable of selectively filtering light from the specimen, and a central processing unit capable of providing selective position control to the light deflector and the addressable spatial filter.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: April 27, 2010
    Assignee: Baylor College of Medicine and William Marsh Rice University
    Inventors: Peter Saggau, Vivek Bansal, Saumil Patel
  • NON-WOVEN FABRIC COMPOSITES FROM LIGNIN-RICH, LARGE DIAMETER NATURAL FIBERS
    Publication number: 20100093245
    Abstract: A non-woven fabric composite containing natural fibers and a method for producing such composites. The non-woven fabric composite is comprised of large diameter, lignin-rich natural fibers with a high viscous flow temperature and a high degradation temperature combined with fibers made of a thermoplastic polymer with a lower viscous flow temperature such as polypropylene, polyethylene or a biodegradable thermoplastic polymer fiber such as polylactic acid, or mixture thereof. A hot-pressed non-woven fabric composite material prepared from the non-woven fabric composite.
    Type: Application
    Filed: October 6, 2009
    Publication date: April 15, 2010
    Applicant: Baylor University
    Inventors: Walter Bradley, David Stanton Greer
  • Isolation and identification of T cells
    Patent number: 7695713
    Abstract: The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as multiple sclerosis or rheumatoid arthritis using autologous T cell vaccines. The invention is further directed to the diagnosis of T cell associated diseases.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: April 13, 2010
    Assignee: Baylor College of Medicine
    Inventor: Jingwu Z. Zang
  • Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin B peptides
    Patent number: 7691587
    Abstract: The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresistance to botulinum toxin therapy in an individual, methods of reducing anti-botulinum toxin antibodies in an individual and methods of inducing a BoNT/B immune response an individual.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: April 6, 2010
    Assignees: Allergan, Inc., Baylor College of Medicine
    Inventor: M. Zouhair Atassi
  • Cannula tip for a cardiac assist device
    Patent number: 7686758
    Abstract: The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical body of the cannula tip with gaps between the projections. The projections may have beveled edges. The inlet portion of the cannula tip can accept blood flow from either the gaps in the side or from the bottom of the tip. Even if the edge of the cannula tip is close to or even touching ventricle wall, a suction condition will not result, as blood is allowed to flow through the gaps between the projections.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: March 30, 2010
    Assignees: HITMAC (USA), Inc., Baylor College of Medicine
    Inventors: Yukihiko Nosé, Toshiyuki Shinohara, Kuniyoshi Watanabe, Tadashi Motomura
  • Diagnosis of Metastatic Melanoma and Monitoring Indicators of Immunosuppression Through Blood Leukocyte Microarray Analysis
    Publication number: 20100076691
    Abstract: The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes.
    Type: Application
    Filed: November 3, 2007
    Publication date: March 25, 2010
    Applicant: Baylor Research Institute
    Inventors: Anna Karolina Palucka, Jacques F. Banchereau, Damien Chaussabel