Abstract: Provided are oligosaccharides, compositions comprising oligosaccharides, formulations thereof, methods for modulating microbiota and their metabolic products, and methods for the use of same as therapeutics for treating, preventing, or improving conditions associated with various health conditions, including gastrointestinal health, cardiovascular health, renal system health, central nervous system health, immune system health, and urogenital health.
Type:
Application
Filed:
May 12, 2022
Publication date:
September 19, 2024
Applicant:
BCD BIOSCIENCE, INC.
Inventors:
Matthew Joseph AMICUCCI, Angela Maria MARCOBAL-BARRANCO, Steven Michael WATKINS, Maria Ximena MALDONADO GĂ“MEZ, Nithya KRISHNAKUMAR, Cory Glen VIERRA, Alexandria Marie Salazar CONNER, Riley Anne DREXLER, Yiyun LIU, Jennifer Elizabeth NILL, Bruce Robert MCCONNELL, James Patrick CERNEY, Megan LEE
Abstract: Provided are methods for cleaving polysaccharides, comprising reacting polysaccharides with a Fenton's reagent, and cleaving the treated polysaccharides with a nitrogen-based cleavage reagent, which preferably is also a peroxide-quenching agent. Synthetic oligosaccharide compositions produced by such polysaccharide cleaving methods are further disclosed. Such oligosaccharide compositions are shown to provide utility in various aspects including modulating microbial growth and/or microbial or host metabolism.
Type:
Application
Filed:
November 12, 2020
Publication date:
November 24, 2022
Applicant:
BCD Bioscience, Inc.
Inventors:
Matthew Joseph AMICUCCI, Cory Glen VIERRA, Riley Anne DREXLER, Kevin Patrick WORRELL, Yiyun LIU