Abstract: The present invention provides compositions and methods for immunotherapy in human. The invention includes a B cell receptor like complex expressed in T cells and comprising an extracellular antigen recognition domain, a trans-membrane domain, a CD79?? heterodimer, and a signaling region that controls T cell activation. The extracellular antigen recognition domain and trans-membrane are derived from the same human or humanized B cell receptor and form a single unit in the complex. The signaling region comprises a T cell signaling domain in combination with a co-stimulatory signaling domain. The signaling region is fused to the CD79?? heterodimer. Furthermore, the B cell receptor like complex of the present invention can use a targeting molecule as a bridge between cytotoxic T cells and targeted cells.
Type:
Application
Filed:
October 26, 2015
Publication date:
December 14, 2017
Applicant:
BCRT Holding BV
Inventors:
Mark De Boer, Carsten Linnemann, Antonius Nicolaas Maria Schumacher, Riccardo Mezzadra