Patents Assigned to BD KIESTRA B.V.
  • Patent number: 11319575
    Abstract: An imaging system and method provides automated microbial growth detection for antibiotic sensitivity testing. A processing system having an image sensor for capturing images of an inoculated culture plate having antibiotic disks disposed on the culture media captures images of the plate at separate times (e.g., first and second images). The system generates pixel characteristic data for pixels of the second image from a comparison of the first image and second image. The pixel characteristic data may be indicative of plate growth. The system may access growth modeling data concerning the antibiotic disk(s) and generate simulated image data with a growth model function. The growth model function uses the growth modeling data. The simulated image data simulates growth on the plate relative to the disk(s). The system compares the simulated image and the pixel characteristic data to identify pixel region(s) of the second image that differ from the simulated image.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: May 3, 2022
    Assignee: BD KIESTRA B.V.
    Inventor: Raphael Rodolphe Marcelpoil
  • Publication number: 20220098542
    Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
    Type: Application
    Filed: September 8, 2021
    Publication date: March 31, 2022
    Applicant: BD KIESTRA B.V.
    Inventors: Martijn Xander Berntsen, Jurjen Sinnema, Martijn Kleefstra
  • Patent number: 11262368
    Abstract: An apparatus for conveying a plurality of articles includes a transport belt, a bumper stopper, and a rotator. A motor moves the transport belt which is adapted to rotate the rotator as the belt conveys the plurality of articles. The stopper can move between first and second positions relative to the transport belt wherein the bumper stopper guides one article toward the rotator when the bumper stopper is in the first position. The bumper stopper allows the article to be conveyed to another location when the bumper stopper is in the second position. The transport belt can continue to convey other articles while the one article is temporarily held in place by the bumper stopper. The rotator is configured to rotate the article conveyed by the transport belt. The article can remain in contact with the transport belt while the rotator is rotating the article.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: March 1, 2022
    Assignee: BD KIESTRA B.V.
    Inventors: Jurjen Sinnema, Roger Petri, Martijn Xander Berntsen, Martijn Kleefstra
  • Publication number: 20220033125
    Abstract: A holder for consumables for use in an analyzer is disclosed. The holder has one or more receptacles for receiving a stack of consumables. The consumables are wrapped in packaging and are placed in the holder as a stack of packaged consumables. The receptacles have a height sufficient to receive the stack of consumable. The receptacles have an opening miming along the side of the receptacle for the entire portion of the height of the receptacle that receives the stack of consumables. The receptacles have a proximal end and a distal end. The proximal end is the end of the receptacles into which the stack of consumables is place and from which the consumables are removed. The distal portion of the receptacles support the stack of consumables in the receptacles.
    Type: Application
    Filed: October 4, 2018
    Publication date: February 3, 2022
    Applicant: BD KIESTRA B.V.
    Inventors: Jurjen Sinnema, Roger Petri
  • Publication number: 20220018866
    Abstract: An improved system and method for the selection and dispensing of reagents onto a target testing medium in an automated laboratory environment. The system utilizes multiple carousels rotatably-mounted upon a central turntable. The position of the central turntable, as well as the rotation of each carousel is controlled by a microprocessor-based control system. Multiple dispensers, each capable of storing and dispensing a particular reagent, are mounted about the circumference of each carousel. This configuration provides much higher reagent density than previously available. The testing medium is positioned at one or more loading stations. The control system directs the central turntable to a position from which a selected one of the carousels can be rotated so as to position a selected dispenser above the testing medium. The selected dispenser is then actuated to release a predetermined reagent onto the testing medium.
    Type: Application
    Filed: December 3, 2019
    Publication date: January 20, 2022
    Applicant: BD KIESTRA B.V.
    Inventors: Michael John Wilsher, Simon Jowett, Roy Norman Gladwin, Mark William Horobin, Kenneth Charles Smith, Duncan Stevenson, Timothy Roy Hansen, Johannes Wijnandus Thiecke
  • Publication number: 20220002130
    Abstract: A system and method for a self-actuating, mechanically-biased container restraint. The system requires no computer-aided control or timing, nor is any external power source needed, other than the force exerted as a container is inserted into the restraint. The system relies upon an assembly including mechanically-biased pivoting levers, each of which has a horizontal element and a vertical element. All actuation occurs as the base of an inserted container comes into contact with the upper surface of the horizontal elements of multiple pivoted levers positioned at the base of a channel adapted to serve as a guide for the inserted tube. The levers are biased in this elevated position by mechanical means, such as a spring. As the inserted tube presses the horizontal members downward, the top portions of the vertical members are pivoted inward toward the container's exterior.
    Type: Application
    Filed: October 28, 2019
    Publication date: January 6, 2022
    Applicant: BD KIESTRA B.V.
    Inventors: Jurjen Sinnema, Franciscus Feijen
  • Patent number: 11186861
    Abstract: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for streaking a microbial sample onto a solid carrier, comprising the steps of: a) contacting at least one ferromagnetic particle with a solid carrier, followed or preceded by providing the particle with at least part of said sample, and b) applying a magnetic field gradient to allow for magnetically controlled motion of said particle on said surface, such that at least part of the sample is streaked onto the solid carrier. Also provided is an apparatus for carrying out such method in an (semi-)automated fashion.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 30, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Trienko Marten Van Der Kaap, Martijn Kleefstra, Ingela Marie Sofie Edlund Tjernberg, Jetze Botma
  • Publication number: 20210334514
    Abstract: An imaging method for earliest microbial growth detection. The method uses images to determined colony biomass, and the colony biomass determines when the colony can be picked for analysis for identification or antibiotic susceptibility testing. If the sample source is not a pure sample source additional incubation may be required to permit an increase in biomass of the colonies prior to pick.
    Type: Application
    Filed: December 19, 2019
    Publication date: October 28, 2021
    Applicant: BD KIESTRA B.V.
    Inventor: Raphael Rodolphe Marcelpoil
  • Patent number: 11136544
    Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: October 5, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Xander Berntsen, Jurjen Sinnema, Martijn Kleefstra
  • Publication number: 20210270862
    Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 2, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Martijn Kleefstra, Martijn Xander Berntsen, Jan Bart Van Der Vijver, Tsjerk Nauta, Andrej Girgenson
  • Publication number: 20210239582
    Abstract: The present invention describes an automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
    Type: Application
    Filed: April 20, 2021
    Publication date: August 5, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Martijn Xander BERNTSEN, Martijn Kleefstra, Roger Petri, Tino Walter Van Der Zee
  • Publication number: 20210199546
    Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
    Type: Application
    Filed: June 24, 2019
    Publication date: July 1, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Timothy Roy Hansen, Martijn Kleefstra, Michael Bois, Timothy M. Wiles, Charles Chak Cheung Yu
  • Patent number: 11041871
    Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: June 22, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Kleefstra, Martijn Xander Berntsen, Jan Bart Van Der Vijver, Tsjerk Nauta, Andrej Girgenson
  • Patent number: 11016007
    Abstract: The present invention describes an automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: May 25, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Xander Berntsen, Martijn Kleefstra, Roger Petri, Tino Walter Van Der Zee
  • Publication number: 20210116471
    Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.
    Type: Application
    Filed: December 29, 2020
    Publication date: April 22, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Timothy R. Hansen, Rick Holtz, Martijn Kleefstra, Raphael Rodolphe Marcelpoil, Rick Pierpont, Brent Ronald Pohl, Alyssa Shedlosky, Scott Shindledecker, Edward Skevington, Kerry Lynn Smith, Timothy Wiles
  • Patent number: 10935490
    Abstract: A nephelometer that measures turbidity of low volume suspensions using measurements of light transmitted through and/or scattered by the sample. The sample suspension is placed in a tiered cuvette adapted to facilitate measuring the turbidity of low volume samples. The lower portion of the cuvette has smaller dimensions, in horizontal cross section, than the top portion. Both lower and upper portions have angled surfaces. The lower, smaller portion of the cuvette is interrogated by the nephelometer.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: March 2, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith
  • Publication number: 20210055318
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Patent number: 10921336
    Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 16, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Timothy Roy Hansen, Rick Holtz, Martijn Kleefstra, Raphael R. Marcelpoil, Rick Pierpont, Brent Ronald Pohl, Alyssa Shedlosky, Scott Shindledecker, Edward Skevington, Kerry Lynn Smith, Timothy M. Wiles
  • Patent number: 10859588
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: December 8, 2020
    Assignee: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Patent number: 10841503
    Abstract: An image capture system and method for imaging biological samples disposed in culture media supported by a plate. The system has a calibration module, an image acquisition module and an image presentation module. When the system receives a culture plate for imaging, default values for the culture plate and media are used to begin image acquisition at a given time. The captured image is then used to create a pixel by pixel map of the image. The system inspects the pixel-by-pixel map for saturated pixels and for signal to noise ratio and acquires a new image if the number of saturated pixels is at or above a predetermined threshold or the signal to noise ratio for the pixel is below a predetermined threshold. From this inspection a new value of photon flux and/or exposure time is determined and a new image is captured using the new value and the steps are repeated.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: November 17, 2020
    Assignee: BD KIESTRA B.V.
    Inventors: Raphael R. Marcelpoil, Cedrick Orny, Didier Morel