Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.

Abstract: A phase shifter includes functional actively controlled phase-shift elements formed with TSVs. The phase shifter may include plural phase shifter elements each including: a signal line including a signal line through-substrate-via (TSV) in a substrate; a ground return line including a ground return line TSV in the substrate; a capacitance control line including a capacitance control line TSV in the substrate; and an inductance control line including an inductance control line TSV in the substrate, wherein the phase shifter element has one of a first phase shift and a second phase shift, different from the first phase shift, based on a capacitance and an inductance of the signal line TSV.

Abstract: A deep learning process receives desired process values associated with the one or more process stations. The deep learning processor receives desired target values for one or more key performance indicators of the manufacturing process. The deep learning processor simulates the manufacturing process to generate expected process values and expected target values for the one or more key performance indicators to optimize the one or more key performance indicators. The simulating includes generating a proposed state change of at least one processing parameter of the initial set of processing parameters. The deep learning processor determines that expected process values and the expected target values are within an acceptable limit of the desired process values and the desired target values. Based on the determining, the deep learning processes causes a change to the initial set of processing parameters based on the proposed state change.

Abstract: An antenna alignment device may have a camera that takes a line-of-sight image. For an antenna alignment device directed to a boresight of an antenna, the line-of-sight image is the “view” from the antenna to the surrounding environment. An antenna radiation pattern, based on the antenna type, may be overlaid on the line-of-sight image. A technician and or other user can therefore observe the radiation pattern vis-à-vis the surrounding environment. Therefore, it can be determined during the initial alignment stage, whether the antenna alignment may have to be changed to account for structures and or other blockages in the surrounding environment rather than just relying antenna alignment based on an ideal model site. The overlaying also speeds up troubleshooting as it can be used to provide clear and specific alignment instructions prior to deploying crew to the antenna site.

Abstract: A bicyclophosphate-modified ionic liquid compound, the synthesis thereof, an electrochemical electrolyte containing a bicyclophosphate-modified ionic liquid compound, and energy storage device containing the electrolyte are disclosed.

Abstract: The disclosure provides methods for treating major depressive disorder in a human patient having moderate or severe anhedonia. The methods comprise administering to the patient in need thereof an effective amount of aticaprant, or a pharmaceutically acceptable salt thereof. In some embodiments, the patient had an inadequate response to other antidepressant therapy prior to treatment with aticaprant. In other embodiments, the other antidepressant therapy comprised a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.

Abstract: Systems and methods for tracking media file playback are provided. A request to upload a media file and metadata associated with the media file is received. Next, the media file and metadata is uploaded via a blockchain protocol. Next, a request to play the media file is received from a client device or a digital service provider (DSP) platform. The request to play the media file is validated via the blockchain protocol. Upon validating the request to play the media file, the media file is transmitted for playback at the client device or DSP platform. Last, the number of times the media file is played is tracked via the blockchain protocol.

Abstract: The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion and/or maintenance in vivo and/or in vitro. For example, a method of enhancing T cell-based therapy comprises administering genetically modified T cells comprising a first chimeric antigen receptor (CAR) and a second CAR, wherein a binding domain of the first CAR binds a first antigen, and a binding domain of the second CAR binds a second antigen. The first antigen is different from the second antigen. In embodiments, the first CAR binds a surface molecule or antigen of a white blood cell.

Abstract: A request to identify a data value may be received via a network at a designated one of a plurality of identity nodes. A query that includes the data value may be transmitted to an identity service associated with the designated identity node. A response message from the identity service may include one or more designated network identifiers corresponding with the data value. The designated identity node may communicate with the plurality of identity nodes to identify a plurality of network identifiers corresponding with the data value. A trust ledger may be updated to include a correspondence between a selected one of the network identifiers and the data value.

Abstract: For a given file type, an optimal number of threads to use to copy files of each of a number of different discrete file sizes is determined, using a temporal difference learning, reinforcement learning approach in which file copy time is used as feedback reward reinforcement. A continuous function corresponding to the given file type and outputting the number of threads to use to copy files having this given file type and that are of any input file size is fitted onto the optimal numbers of threads determined for the discrete file sizes.

Abstract: Inspection robot and methods utilizing coolant for temperature management are described. An example inspection robot may include a housing with a couplant retaining chamber, and an electronic board selectively thermally coupled to the couplant retaining chamber. The inspection robot may include a couplant input port coupling a couplant source to a couplant flow path, a drive module coupled to the housing, and a payload with at least one sensor, where the payload is coupled to the housing. The couplant flow path is fluidly coupling the couplant input port to the couplant retaining chamber.

Abstract: An approach to forecasting battery health as a dynamic time-series problem as opposed to a static prediction problem is presented. Systems and methods disclosed herein forecast a trajectory to failure by predicting a path to failure as opposed to only predicting when the battery may fail. A machine-learning model is implemented that extracts unique features taken from time-series data, such as time snippets of charging data. The raw time-series data may include current voltage and temperature with complex transformations and without capturing a full cycle, which permits wider applicability to instances of varying depth of discharge (DoD).

Abstract: A method and apparatus for providing biofeedback during a meditation exercise are disclosed. In one aspect, the wearable device includes one or more biometric sensors and a user interface. The method may involve prompting the user, via the user interface, to perform a meditation exercise, the meditation exercise being associated with a target physiological metric related to the physiology of the user. The method may involve measuring, based on output of at least one of the one or more biometric sensors, a physiological metric of the user during the meditation exercise. The method may involve determining a performance score indicating the user's performance during the meditation exercise based on comparing the measured physiological metric with the target physiological metric. The method may involve providing, via the user interface, based on the performance score, feedback information indicative of the user's performance during the meditation exercise.

Abstract: The invention relates to thermoplastic filament for use in 3-D printers, in which the core of the filament is non-solid or mono-filament. The filament may contain a multitude of small micro-voids, (a micro foam), be a foam-core structure, be hollow, or have a monofilament core. The filament of the invention is especially useful with crystalline and semi-crystalline polymers, and reduces the negative effect of filament voids, formed by shrinkage during the cooling of the filament.

Abstract: A detachable orthodontic bracket and wire system includes bracket bases, brackets, and an arch wire for guiding alignment of teeth. The bracket bases are positioned on a lingual surface and/or a facial surface of the teeth. Each bracket base includes a first surface, a second surface, and at least one first interlocking element. The first surface is rigidly attached to the lingual surface and/or the facial surface of the teeth. The second surface opposes the lingual surface and/or the facial surface of the teeth. The first interlocking element is attached to and positioned in a direction substantially perpendicular to or parallel to the second surface of each bracket base. The brackets include at least second interlocking element that interlocks with the first interlocking element. The arch wire is inserted through a slot channel of each bracket. The bracket and the arch wire are infused and rigidly anchored within enclosing layers.

Abstract: A method includes generating a task using a plurality of logical statements embedded in a database, the plurality of logical statements corresponding to a data modification. Database data is ingested into a staging table that is configured within the database. The task is executed based on applying the data modification to a first set of partitions storing the database data and generating a second set of partitions. The second set of partitions store modified data corresponding to the database data. A stream of committed transactions is advanced at least in part by adding an entry into the stream. The entry corresponds to committed transactions performed on the first set of partitions during the data modification. A data processing task is scheduled for execution on the modified data based on the advancing of the stream offset.

Abstract: Technology for performing data duplication on data that was previously consolidated (e.g., deduplicated or merged). An example method may involve receiving a request to modify a memory page; causing the data at a first storage location to be decrypted using location dependent cryptographic input and then encrypted using a location independent cryptographic input; copying the encrypted data of the memory page from the first storage location to a second storage location; causing the encrypted data at the first and second storage locations to be decrypted using location independent cryptographic input and to each be encrypted using a different location dependent cryptographic input; updating, by the supervisor, one of the references of the plurality of memory pages from pointing to the first storage location in the physical memory to pointing to the second storage location; and modifying the memory page by altering data in the physical memory.

Abstract: Flash peripheral device may include a kernel in logical communication with a bootloader where the kernel, when initialized, is adapted to upload in at least one hardware controller via the bootloader. Flash peripheral device may also include at least one firmware protocol in logical communication with the kernel and configured to initialize at least one hardware driver of the at least one hardware controller. Flash peripheral device may also include an operation application in logical communication with the kernel and provided with a legacy set of instructions and at least one updated set of instructions. The operation application executes and runs the at least one updated set of instructions when the at least one updated set of instructions is flashed to the operation application or executes and runs the legacy set of instructions when the at least one updated set of instructions fails to be flashed to the operation application.

Abstract: Methods, systems, and apparatuses for storage device pool management based on storage device logical to physical (L2P) table information are provided. One such data storage system includes data storage devices each including a non-volatile memory; and a storage management device configured to receive L2P table information from at least two of the data storage devices; receive host data from a host device to be stored in one or more of the data storage devices; select, based on the L2P table information from the at plurality of data storage devices and the size of the host data, a target data storage device from the plurality of data storage devices; and send the host data to the target data storage device.

Abstract: Methods and systems for the use of multi-party computation (“MPC”) key systems that involve the use of multiple parties, each of which hold respective private data that may be used to evaluate a computation without ever revealing any of the private data held by each party to perform blockchain operations. Using the MPC key systems, the methods and systems generate secure, encrypted communications across distributed computer networks for authorizing use of cryptography-based digital repositories in order to perform blockchain operations in decentralized applications.