Abstract: An exhaust manifold comprises a plurality of exhaust intake conduits structured to be fluidly coupled to an engine and receive exhaust gas from a corresponding cylinder of the engine. At least one exhaust intake conduit provides a reduction in an exhaust intake conduit cross-sectional area from an inlet to an outlet. A plurality of bends are each defined by a respective one of the exhaust intake conduit outlets. An exhaust intake manifold is fluidly coupled to the exhaust intake manifold and defines an exhaust intake manifold flow axis. Each of the plurality of bends is shaped so as to define n angle of approach of exhaust gas flowing therethrough. A first angle of approach of the first bend relative to the exhaust intake manifold flow axis is smaller than a second angle of approach of an inner second bend.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

Abstract: The present invention provides novel compounds of Formula (I?), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma)), inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as an interleukin-1 receptor-associated kinase (IRAK) (e.g., IRAKI and/or IRAK4) in the subject.

Abstract: A composite structural panel for use in bridge structures, and method of manufacturing same, comprises a top panel and a bottom panel separated by and attached to at least one, but preferably a plurality, of structural composite preforms which may be fabricated by a continuous manufacturing process and may be saturated by resin using a continuous wetting process. The composite preforms may take any cross sectional shape but are preferably trapezoidal. The top and bottom panels may be fabricated from a plurality of layers of woven fabric layers and non-woven fabric layers which are saturated with a resin that is subsequently cured using cure processes known in the art. The composite structural panel of the invention is usable as a flat structural member for use as bridge decking, ramps, trestles, and any application requiring a structural panel.

Abstract: In biosciences and related fields, it can be useful to modify surfaces of apparatuses, devices, and materials that contact biomaterials such as biomolecules and biological micro-objects. Described herein are surface modifying and surface functionalizing reagents, preparation thereof, and methods for modifying surfaces to activate T Lymphocytes.

Abstract: In non-limiting examples of the present disclosure, taste data is generated and usable within one or more applications. A taste is one or more elements that describe an entity. Information of an application may be processed to extract entity data that corresponds to a plurality of candidates to be designated as tastes (taste data). The candidates for the tastes are curated. In examples, the curating comprises filtering the candidates for tastes to remove extracted candidates. Extraction rules for managing structured taste data may be applied in the filtering. A status of a remaining candidate may be determined as approved or rejected based on processing of received user feedback. Taste data may be generated for an approved candidate. The generating of the taste data may comprise assigning parameters that include a descriptor type and a recommendation type. Taste data may be used within an application.

Abstract: Described herein are embodiments of an approach to diagnosing pancreatic cystic lesions using light scattering spectroscopy. In some embodiments, the approach includes an apparatus including a spatial gating probe to isolate light reflected by the epithelial tissue of the internal cyst surface using spatial gating. In some further embodiments, the apparatus includes a scanning fiber probe that is capable of rotational and linear motion in order to scan the entire internal surface of the cyst. Use of such an approach may be advantageous to improve the accuracy of diagnosing pancreatic cystic lesions as cancerous, precancerous, or benign.

Abstract: A cigarette filter inspection method of inspecting a solid flavor element to be disposed in a void between two filter plugs placed in outer filter wrapper, and the cigarette filter inspection method includes an illumination step of irradiating the void with illumination light, an imaging step of obtaining an inspection image of a region containing the void, a filler detection step of detecting the flavor element based on contrast between the void and the flavor element in the inspection image, and an inspection step of inspecting the flavor element detected in the inspection image.

Abstract: Systems and methods for enforcement of secure data communications between nodes of a Controller Area Network (CAN) bus implemented in a vehicle are provided. According to one embodiment, a node coupled with the CAN bus receives a data frame broadcast from a source node and extracts information from the data frame. The node analyzes coherence between the extracted information and historical information observed by the node. When a result of the analyzing coherence indicates that the data frame is valid (i.e., the extracted information is coherent with the historical information), the node updates the historical information based on the data frame; otherwise the node drops the data frame to discontinue processing of the data frame.

Abstract: A distributed aperture bi-static radar system, apparatus, architecture, and method is provided for coherently combining physically distributed radars to jointly produce target scene information in a coherent fashion by alternately selecting first and second small aperture devices to operate as the master unit so that radar signals are sequentially transmitted from every transmit antenna in the first and second small aperture devices, thereby enabling the radar control processing unit to coherently combine mono-static and bi-static virtual array apertures from the first and second small aperture radar devices to construct an extended bi-static MIMO virtual army aperture that is larger than the bi-static MIMO virtual array apertures produced by the first and second small aperture radar devices.

Abstract: A method of determining a Trac score representing an individual's future employment behavior using past and present employment behavior that are unrelated to skills and job match within a job and across multiple jobs of an individual when combined with public and available external records. A method employing a Trac score calculation system comprises at least one processor to execute computer program instructions for obtaining one or more ratings from one or more users through one or more user devices connected to the Trac score calculation system that assigns the credibility to the ratings. A combination of the Trac sub-score obtained by accumulating the ratings weighted by estimated credibility of each rating, and Adjustment sub-score obtained by processing available external records in public and private forms, creates a Trac score which is a numerical and reflects an aggregation of available data weighted by what is believed to affect the employment behavior.

Abstract: A method of simulating a quadcopter includes recording camera output for one or more video cameras under constant conditions and subtracting a constant signal from the recorded camera output to obtain a camera noise recording. Simulated camera noise is generated from the camera noise recording and is added to a plurality of simulated camera outputs of a quadcopter simulator to generate noise-added simulated camera outputs. The noise-added simulated camera outputs are sent to an Artificial Intelligence (AI) controller coupled to the quadcopter simulator for the AI controller to use to pilot a simulated quadcopter of the quadcopter simulator.

Abstract: An apparatus and method for a sunroof of a vehicle, including a pivot link pivotally coupled to a drive shoe, the pivot link having a first pivot pin configured to slide along a first guide channel of a guide block to control tilting of a movable panel as the drive shoe slides, a lift guide, and a check assembly including a mechanical lock. The mechanical lock includes an inner surface having a locking guide channel to guide a second pivot pin of the pivot link, the locking guide channel includes an upper guide portion. The pivot link is configured to pivot to a raised position to tilt the movable panel when the drive shoe is slid in the forward direction and becomes coupled to the lift guide by the check assembly. The upper guide portion engages the second pivot pin to lock the pivot link in the raised position.

Abstract: A method, system, and computer program product to manage a network comprising a plurality of interconnected components are described. The method includes obtaining a set of all the components that are part of the network over time, and identifying one or more repeating patterns of components among the set of all the components as corresponding lower-level definitions to generate a hierarchical set of all the components. The method also includes obtaining time-varying information regarding topology and operational values within the network, and creating a representation of the network at a set of times based on the hierarchical set of all the components and the time-varying information.

Abstract: The invention, depending on aspect and embodiment, relates to capture probe controls, and capture and signal probe configurations and combinations of configurations that can facilitate accurate and efficient multiplex analyte detection, especially in electrochemical detection schemes.

Abstract: A screen filter fabrication machine configured to produce a screen filter having a controlled slot width between wires. The screen filter fabrication machine can include a frame, a tooling head configured to rotate relative to the frame and retain a plurality of support rods, a wire feed wheel operably coupled to the frame and configured to dispense wire as it is wound around the plurality of support rods, and a control system configured to monitor one or more parameters concerning the slot width, and implement one or more process control adjustments configured to enable the winding of the wire around the plurality of support rods in such a manner that at least 99.7% of a measured slot width during screen filter fabrication falls within three standard deviations of a mean slot width measured during screen filter fabrication.

Abstract: An embodiment of the present invention provides a CSI-RS transmission method, a CSI feedback method, a base station and a mobile station. The transmission method for a base station transmitting a channel state information reference signal (CSI-RS), includes transmitting a first CSI-RS relating to a first antenna port of the base station to a mobile station, forming a second antenna port that is beamformed based on a first CSI feedback received from the mobile station, transmitting a second CSI-RS relating to the second antenna port to the mobile station, and selecting a beam for data transmission to the mobile station, based on a second CSI feedback received from the mobile station.

Abstract: A community discount method for giving insurance discounts to customers of an insurance carrier that are part of communities. The method includes enabling a customer to purchase insurance from the carrier and to organize communities with other customers. A premium reduction is generated for organizing communities. The communities lower carrier expenses. The customer can receive a unique identifier, and other customers can purchase insurance from the carrier using the unique identifier to form a community. A discount can be generated for each customer in the community. The discount can be eliminated when customers cancel their policies. The discount can be a reduction of a factor used for premium calculation. The customer can identify other customers who may vouch for them; and send requests to the identified customers. A reduction can be generated when other customers respond to the vouch request and vouch for the customer.

Abstract: Takedown pins for rifles have a pin movable in a direction along its length between an operating condition and a released condition. The pin has a first end portion that prevents relative movement of the upper receiver with respect to the lower receiver when the pin is in the operating condition. The first end portion has a lower end portion surface adapted to resist upward movement of the upper receiver's lug. The pin has an intermediate portion adjacent to the lower end portion surface defining a lower channel having a lower channel surface above the level of the lower end portion surface. When the pin is in the released condition, the lower channel is registered with the lug, and the lug is enabled to move upward with respect to the lower receiver by a limited distance to a disengaged position.

Abstract: Some embodiments provide an autonomous navigation system which autonomously navigates a vehicle through an environment based on predicted trajectories of one or more separate dynamic elements through the environment. The system identifies contextual cues associated with a monitored dynamic element, based on features of the dynamic element and actions of the dynamic element relative to various elements of the environment, including motions relative to other dynamic elements. A monitored dynamic element can be associated with a particular intention, which specifies a prediction of dynamic element movement through the environment, based on a correlation between identified contextual cues associated with the monitored dynamic element and a set of contextual cues which are associated with the particular intention. A predicted trajectory of the dynamic element is generated based on an associated intention.