Abstract: The present invention provides compounds and methods for modulating target nucleic acids found in organelles or sub-organelles of cells. The invention includes, but is not limited to compounds and methods that modulate target nucleic acids in a sub-nuclear organelle, such as the nucleolus and/or a cajal body. In certain embodiments, the cell is in an animal.

Abstract: An air turbine start system is provided that includes an air turbine starter, a starter air valve, a turbine speed sensor, and a circuit. The starter air valve is movable between an open position, in which the pressurized air may flow into the air turbine starter, and a closed position, in which pressurized air does not flow into the air turbine starter. The turbine speed sensor is coupled to the air turbine starter, and is configured to sense the rotational speed of the turbine and supply a rotational speed signal representative thereof. The circuit is coupled to receive the rotational speed signal and is configured, upon receipt thereof, to determine whether the starter air valve is in the closed position or an open position.

Abstract: An accessibility-enhancing joint module may include a housing, a powered motor disposed within the housing, a rotatable receiving member operatively connected to the powered motor, a coupling element configured to attach to the receiving member, and a control board disposed within the housing and operatively connected to the powered motor, wherein the coupling element is disposed external to the housing. An accessibility-enhancing arm assembly may include a first joint module and a second joint module and a tubular arm member attached to the proximal mounting portion of the first joint module and the proximal mounting portion of the second joint module, each joint module including a housing having a body portion and a proximal mounting portion, a powered motor disposed within the housing, and a rotatable receiving member operatively connected to the powered motor. The joint module(s) and/or the arm assembly may be operable by a variety of accessible controls.

Abstract: A carrier for receiving and restraining a container against rotation during an automated filling and capping operation includes an array of modular container housings. A bumper is disposed below the housing and projects outwardly to cushion the carrier against impact. The bumper is supported by a base. Structure extends from the housing through the bumper and into the base to secure the carrier. One housing module includes a recess having container abutment surfaces and angled surfaces at the opening to guide a container into engagement with the abutments. One housing module includes a recess having ribs separated by relief vents to relieve air pressure as a container is loaded into the carrier. One housing module includes a container holder having a pair of upright supports separated by side openings. The bumper and the base each including a weight positioned at a selected location to uphold the filled container.

Abstract: The rapid assembly flange joint consists of a connecting device in the form of a constricting collar made up of at least two parts with a shaped groove on the concave face, the groove corresponding to the cross-section of the two coupled flanges of the members that are being connected, and clamping elements in the form of retaining sections on the flanges. The connecting device is provided with fasteners in the form of walls; the retaining sections are in the form of grooves, the width of which is not less than the thickness of the one or two fasteners that engage therewith. The number of grooves is not less than the number of component parts of the connecting device. The rapid assembly flange joint provides for a reliable connection between flanged cylindrical members without the need for additional fastening and clamping elements and without increasing the sizes of the connection point.

Abstract: An organic light-emitting diode display may have an array of pixels. Each pixel may have multiple subpixels of different colors. To avoid undesired color shifts when operating the display, the display may be configured so that subpixels of different colors are not coupled to each other through parasitic capacitances. The subpixels may include red, green, and blue subpixels or subpixels of other colors. Each subpixel may include an organic light-emitting diode having an anode and a cathode. The anode of each organic light-emitting diode may be coupled to a respective storage capacitor. Capacitive coupling between subpixels can be minimized by configuring the subpixel structures of each pixel so that the storage capacitors of the subpixels do not overlap the anodes of other subpixels in the pixel. Anode and capacitor overlap with subpixel data lines may also be reduced or eliminated.

Abstract: A preexisting FMS system may be upgraded to increase its functionality by optimizing the control of autopilot and auto-throttle functions and replacing other preexisting components with different components for enhancing the functionality of the FMS system. The preexisting IRU, CADC, DME receiver and DFGC in the upgraded FMS system are in communication with the legacy AFMC but, instead of employing the legacy EFIS, the EFIS is replaced by a data concentrator unit as well as the display control panel and integrated flat panel display, and a GPS receiver. The upgraded FMS system is capable of iteratively controlling the autopilot and auto-throttle during all phases of flight and of such increased functionality as increased navigation database storage capacity, RNP, VNAV, LPV and RNAV capability utilizing a GPS based navigation solution, and RTA capability, while still enabling the legacy AFMC to exploit its aircraft performance capabilities throughout the flight.

Abstract: A ram with a multi-axis, multi-directional “self-centering shell holder” having predetermined spacing with respect to its engagement with the shell holder so that the shell holder supporting the cartridge case has the ability to deviate from the ram centerline in any direction to re-align with a centerline of the die bore is provided. The present invention also provides a retaining clip with push down tab allowing for quick insertion and removal of the self-aligning shell holder from the ram top.

Abstract: The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

Abstract: A powered device (PD) receives a Power-over-Ethernet (PoE) voltage to power the PD over a cable from Power Source Equipment (PSE) configured to output a requested one of multiple candidate PoE voltages to the cable. The PD determines a preferred PoE voltage among the multiple candidate PoE voltages that minimizes a total power loss due to (i) the cable, and (ii) a power loss of the PD that would result if the PD were powered through the cable. The PD requests the preferred PoE voltage from the PSE, receives the preferred PoE voltage from the PSE, and operates at the preferred PoE voltage.

Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.

Abstract: A lock assembly (30, 30?) is provided that includes a housing (32), a rotary bolt (36) or a translating bolt (36?), and a bolt blocker (38) that moves between a blocking position blocking movement of the bolts (36, 36?) and an unblocking position permitting the bolts (36, 36?) to move to a retracted position. The lock assemblies (30, 30?) are resistant to shocks being applied to the locks assemblies (30, 30?) in an effort to open the lock assemblies (30, 30?) without authorization.

Abstract: Techniques are described for facilitating the awarding of prizes in chance-based contests in various ways, such as chance-based contests which are part of promotional advertising, etc. In at least some embodiments, the techniques include facilitating the awarding of prizes at the time a contestant enter or plays the contests, while awarding a selected number of prizes, which may be determined before the contest starts. In at least some embodiments, the techniques include employing an award counter to control awarding of prizes in a chance-based contest. For example, an award counter may be incremented at random or pseudo-random times. In at least some embodiments, the contest is associated with a location-based virtual group of users that has one or more associated geographical areas.

Abstract: A wheel assembly includes a spindle; a wheel hub rotatable relative to the spindle; and a seal mounted between the spindle and the wheel hub, the spindle, the wheel hub, and the seal defining a sealed cavity, the seal having a first axial end and a second axial end, the first axial end coupled to the spindle, the second axial end coupled to the wheel hub.

Abstract: A method for operating a closure panel of a vehicle, comprising: using a processor, determining whether a first proximity sensor and a second proximity sensor located on a periphery of the vehicle have been sequentially activated to indicate an object moving across the first proximity sensor and the second proximity sensor; and, controlling the closure panel to open or close when the first proximity sensor and the second proximity sensor have been sequentially activated.

Abstract: A game system includes a game processing section that performs a game process, a lottery processing section that sets a lottery range that specifies a range of items among a plurality of items used during the game process that are subjected to a lottery process, and selects an item from the items that belong to the lottery range by performing the lottery process, and an item acquisition processing section that performs a process that allows a player to acquire the selected item. Information about the plurality of items has a data structure in which the plurality of items are linked to have a parent-child relationship. The lottery processing section sets the lottery range so that a child item is included within the lottery range when a parent item has been set to an acquired state or an acquirable state, and changes the set lottery range based on given information.

Abstract: A guide wire (1) for use with a catheter comprises a core wire (3) terminating in a distal portion (18) of flat ribbon-like construction having respective opposite major surfaces (29,30). A spring (24) is brazed to a distal end (27) of the distal portion (18) and to the core wire (3) at a tapering portion (14). A reinforcing member (38) extends axially along the distal portion (18) from a proximal end (26) of the distal portion (18) to a location (40) for reinforcing the distal portion (18) for in turn increasing its torsional rigidity in order to minimize axial twisting of the distal portion (18).

Abstract: A valve actuation system for an internal combustion engine is disclosed. The engine has a first set of cylinders having a first set of exhaust valves and a second set of cylinders having a second set of exhaust valves. The valve actuation system for the exhaust valves includes one or more first cams having a compression-release lobe and a main exhaust lobe adapted to transfer valve actuation motion to the first set of exhaust valves, and one or more second cams having an early exhaust valve opening (EEVO) lobe and a main exhaust lobe adapted to transfer valve actuation motion to the second set of exhaust valves. The valve actuation system may provide any combination of (i) main exhaust valve actuation with or without compression release actuation with (ii) main exhaust valve actuation with or without EEVO for the two sets of cylinders.