Abstract: This invention relates to novel Thieno- and Furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives of formula I and their use as TRPC5 modulators, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment of TRPC5 receptor mediated disorders or conditions. A, R1, R2, R3 and R4 have meanings given in the description.

Abstract: Metal oxide catalysts comprising various dopants are provided. The catalysts are useful as heterogenous catalysts in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons such as ethane and ethylene. Related methods for use and manufacture of the same are also disclosed.

Abstract: An article of footwear is disclosed that includes an upper and a sole structure secured to the upper. The sole structure incorporates a support element that includes a fluid-filled chamber. The chamber may be bonded to other portions of the sole to secure the chamber within the sole. A surface of the chamber may also be angled to form a corresponding bevel in a lower surface of the sole structure, potentially in a rear-lateral area of the sole structure. A plate may also extend under a portion of the chamber.

Abstract: There are provided compounds of formula (I): wherein X1 is O, NH, or S; X2 is O, NH, or S; and X3 is O, NH, or S; and wherein R, R1, T1 and T2 can represent various entities. Such compounds can be useful, for example, for preventing, palliating or treating various diseases such as heart diseases, respiratory diseases, treating inflammatory abnormalities, metabolic disorders or diabetes.

Abstract: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner.

Abstract: A data processing system having a first processor, a second processor, a local memory of the second processor, and a built-in self-test (BIST) controller of the second processor which can be randomly enabled to perform memory accesses on the local memory of the second processor and which includes a random value generator is provided. The system can perform a method including executing a secure code sequence by the first processor and performing, by the BIST controller of the second processor, BIST memory accesses to the local memory of the second processor in response to the random value generator. Performing the BIST memory accesses is performed concurrently with executing the secure code sequence.

Abstract: A mobile terminal having a terminal body and a display unit for outputting an image to a first surface of the terminal body is provided. The display unit includes a liquid crystal (LC) panel configured to form the image by receiving an electric signal, the LC panel being disposed to face the first surface of the terminal body, a driver integrated circuit (IC) configured to apply the electric signal to the LC panel, the driver IC being mounted to a first surface of the LC panel adjacent to a first edge of the LC panel and a light source portion configured to provide light to the LC panel, the light source portion being disposed close to a second edge of the LC panel opposite to the first edge.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to cancer. In particular, the disclosure includes the identities of genes that are expressed in correlation with tumor grade. The levels of gene expression are disclosed as a molecular index for determining tumor grade in a patient and predicting clinical outcome, and so prognosis, for the patient. The molecular grading of cancer may optionally be used in combination with a second molecular index for diagnosing cancer and its prognosis. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer. For diagnosis or prognosis, the disclosure further includes methods for determining or selecting the treatment of cancer based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.

Abstract: Disclosed are a semiconductor device and a manufacturing method thereof, which can achieve miniaturization and improvement in the integration level by forming a substrate using a pattern layer implemented on a wafer in a semiconductor fabrication (FAB) process. In one exemplified embodiment, the manufacturing method of the semiconductor device includes preparing a first semiconductor die including a plurality of through electrodes and a plurality of first conductive pillars, mounting the first semiconductor die to connect the first conductive pillars to the pattern layer provided on a wafer, forming a first encapsulant to cover the pattern layer and the first semiconductor die, mounting a second semiconductor die to electrically connect second conductive pillars provided in the second semiconductor die to the plurality of through electrodes exposed to a second surface of the first semiconductor die, and removing the wafer from a first surface of the pattern layer.

Abstract: A system includes a memory configured to store executable code and a processor operably coupled to the memory. The processor is configured to execute the code to receive a request from a developer of a first web application to provide a notification corresponding to the first web application, authenticate the developer using a client identifier, after authenticating the developer, receive a content of the notification and a first user identifier, and provide the content of the notification to at least one of a plurality of computing devices associated with the first user identifier, based on an account associated with the first user identifier. The system syncs the notification and a plurality of computing devices associated with the first user identifier, based on the account.

Abstract: A method and a system for operating a subscriber unit to seamlessly switch between a trunked mode operation (TMO) and a direct mode operation (DMO) in a communication system. The communication system includes one or more subscriber units communicating in trunked mode operation on a first communication channel via a base station and the subscriber units communicating in direct mode operation on a second communication channel via a direct mode gateway station. When the subscriber units communicate in the TMO and when the signal quality on the first communication channel is below the predetermined threshold, the subscriber units automatically switch to the direct mode operation. When the subscriber units communicate in DMO and when the signal quality on the second communication channel is below the predetermined threshold, the subscriber units automatically switch to the trunked mode operation.

Abstract: A holding structure for holding a plurality of culture plates in a stacked arrangement includes a feature for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting of the bottom culture plate from the adjacent culture plate facilitates withdrawal of the bottom culture plate from the base via a robotic plate transfer mechanism. The de-nesting feature can be entirely passive, such as ramps formed in the base of the holding structure.

Abstract: Disclosed herein is an information processor that allows for manipulation of raw data to a certain extent with an application program while protecting the content of raw data. The information processor acquires encrypted media data, decodes the encrypted media data to generate raw data, scrambles the raw data to generate scrambled data, descrambles the scrambled data to generate the raw data, and outputs the raw data to a player.

Abstract: Devices, methods, and software are disclosed for capturing a frame of image data having a representation of a feature. In an illustrative embodiment, a device includes an imaging subsystem, one or more memory components, and a processor. The imaging subsystem is capable of providing image data representative of light incident on said imaging subsystem. The one or more memory components include at least a first memory component operatively capable of storing an input frame of the image data. The processor is in communicative connection with executable instructions for enabling the processor for various steps. One step includes receiving the input frame from the first memory component. Another step includes generating a reduced resolution frame based on the input frame, the reduced resolution frame comprising fewer pixels than the input frame, in which a pixel in the reduced resolution frame combines information from two or more pixels in the input frame.

Abstract: Disclosed are systems and methods of injecting steam into a wellbore. One disclosed injection tool includes a body defining an inner bore and a radial flow channel, one or more fluid conduits defined in the body at the radial flow channel, a shroud arranged about the body such that an annulus is defined and in fluid communication with the one or more fluid conduits and the surrounding wellbore environment, a sleeve arranged within inner bore and movable between a first position, where the sleeve occludes the one or more fluid conduits, and a second position, where the one or more fluid conduits are exposed, and first and second seals generated at opposing axial ends of the radial flow channel when the sleeve is in the first position.

Abstract: A valve having a first housing including a first lumen extending therethrough and a first disk-facing surface, a second housing including a second lumen extending therethrough and a second disk-facing surface, where the second housing is coupled to the first housing so that the second disk-facing surface faces the first disk-facing surface. A flexible disk has at least a portion of an outer edge of the disk extending away from a plane of a central portion of the disk, the outer edge contacting the first disk-facing surface, the disk including a slit extending therethrough which, when acted upon by a fluid pressure of at least a threshold level opens to permit fluid flow between the first and second lumens and which, when acted upon by a fluid pressure less than the threshold level, prevents fluid flow between the first and second lumens.

Abstract: This disclosure provides systems, methods and apparatus for illumination devices. In one aspect, an illumination device having a longitudinal axis includes a light source and a light guide. The light guide has a peripheral edge, a transmissive illumination surface, a center portion, and an upper surface. The transmissive illumination surface is oriented perpendicular to the longitudinal axis and disposed between the center portion and the peripheral edge. The upper surface is oriented relative to the illumination surface to define an angle ? therebetween. In some implementations, the angle ? can be greater than 15 degrees, for example.

Abstract: An architecture for a load-balanced groups of multi-stage manycore processors shared dynamically among a set of software applications, with capabilities for destination task defined intra-application prioritization of inter-task communications (ITC), for architecture-based ITC performance isolation between the applications, as well as for prioritizing application task instances for execution on cores of manycore processors based at least in part on which of the task instances have available for them the input data, such as ITC data, that they need for executing.

Abstract: A split gate NAND flash memory structure is formed on a semiconductor substrate of a first conductivity type. The NAND structure comprises a first region of a second conductivity type in the substrate with a second region of the second conductivity type in the substrate, spaced apart from the first region. A continuous first channel region is defined between the first region and the second region. A plurality of floating gates are spaced apart from one another with each positioned over a separate portion of the channel region. A plurality of control gates are provided with each associated with and adjacent to a floating gate. Each control gate has two portions: a first portion over a portion of the channel region and a second portion over the associated floating gate and capacitively coupled thereto.