Abstract: A method of real-time noise reduction including generating spectral data using temporally localized spectral representations of a received audio signal, determining detection of voice by comparing first and second filtered data, and generating noise-reduced audio output by attenuating noise based on the determined detection of voice. The first and second filtered data are formed by attenuating temporal variations of the spectral data based on, respectively, a first timescale and a second timescale. A noise reduction system, comprising processing circuitry configured to execute a method of real-time noise reduction to generate an output that is transmitted via an output port of the noise reduction system. A noise-reduction microphone comprising a housing having a transducer coupled to a processor therein to execute a method of real-time noise reduction, and an output port. A non-transitory computer-readable medium having instructions to cause a processor to perform a method of real-time noise reduction.