Abstract: A topical composition for the cosmetic treatment of the human skin and of the type comprising a vehicle in the form of squalane and high contents of active anti-oxidative substances, which composition comprises Chilean Grape Seed Extract (GSPE) in the form of a cream or a serum solution and comprises said active anti-oxidative substances in the form of resveratrol and procyanidin. The use of a topical composition according to any of the proceeding claims where one or more drops of said serum solution or a small amount of said cream is applied to the skin by way of example the skin of the back of a hand and is mixed with a suitable amount of make-up, which make-up mixture afterwards is applied to the skin of the face.