Abstract: A server stores a set of laboratory applications to process batches of samples. The server receives, from a first lab administrator, a selection of a subset of the laboratory applications to process the batches of samples and an admin configuration for a laboratory application in the subset. The server receives configuration(s) of batch(es) to be used for running at least a portion of the subset of laboratory applications configured according to the admin configuration. The server receives, from a first scientific device, a request to run a laboratory application form the first subset to process a batch. The server provides the laboratory application(s) that are capable of being executed using the first scientific device. The server receives, from the first scientific device, a selected laboratory application. The server transmits, to the first scientific device, a signal for executing a first part of the selected laboratory application.

Abstract: Systems and methods for characterizing immune response to infection using cellular analysis, such as a hematological cellular analyzer. In some instances, the immune response may be characterized as normal or abnormal based on one or more blood cell population parameters. In some instances, abnormal characterization may be used to identify patients with sepsis or at elevated risk of developing sepsis.

Abstract: A middleware device or software may be placed in communication with one or more testing instruments and a lab information system. As samples are collected from patients and tested with the testing instruments, test results pass through the middleware and are analyzed in context with other data, such as patient history, testing instrument history, and test results from other tests of the sample, in order to determine whether a particular result is acceptable, whether retesting is needed, whether additional sample collection or testing is needed, and whether currently ordered testing is still necessary. When the middleware determines a need for additional testing or retesting it may automatically create orders for such testing in order to reduce delays in manual review of testing results.

Abstract: The method involves drying down dye-conjugated reagents in separate locations in a reaction vessel so that the dyes don't non-specifically interact with each other during drying. This invention thus improves multiplex binding assays by eliminating erroneous results caused by dyes' being non-specifically attached to each other when dried down together.

Abstract: The disclosure relates to, among other things, an automated flow cytometric method and system for the analysis and enumeration of at least one of hematopoietic stem cells, hematopoietic progenitor cells, and T-cells.

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

Abstract: Methods and systems for determining a dose of an analyte in an unknown sample on an instrument, such as a nucleic acid analyzer, immunoassay analyzer, or clinical chemistry analyzer using a reagent from a selected assay lot are described. The methods and systems use core dose-response information based on measurements of response values to a set of calibrators on a plurality of other instruments and assay lot-specific response information to calibrate the instrument.

Abstract: An optimized testing method is used to determine minimum inhibitory concentration (MIC) of a particular antimicrobic for use with a particular microbe. The testing method includes iteratively imaging the microbes mixed with various concentrations of the antimicrobic. The images are thereafter processed to determine one or more of the amount/count of the microbes in each image, the total area occupied by the microbes in each image, and the ratio between the area occupied by the microbes and the count of the microbes. Once a sufficient amount of data is collected, the MIC is determined based on one or more of the count, area, and ratio datasets.

Abstract: Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.

Abstract: This invention provides methods to evaluate therapeutic efficacy of therapeutic monoclonal antibodies.

Abstract: Monitoring devices, such as air particle counters, having mesh network capabilities are described for implementation in environmental monitoring within a facility. The air particle counters run samples at various facility locations based on a standard operating procedure (SOP). Each air particle counter can opportunistically connect with one or more other air particle counters using mesh networking. Data from samples run by and any new or updated SOP received at the air particle counters can be distributed via database replication across the other air particle counters using the mesh networking such that each air particle counter has a copy of the sample data and a current SOP within its database. A dashboard user interface displaying a hierarchical representation of the SOP and an associated compliance status with the SOP can be generated and updated based on data received from the air particle counters to facilitate SOP management.

Abstract: This disclosure is directed to methods and devices (300) associated with Point of Care medical testing and diagnostics. More specifically, methods and devices are described which provide a quick and streamlined way to prepare blood samples for analysis using flow cytometers, microscopes, and other analysis platforms. The benefits include a reduction in the time, resources, and expertise needed for preparing those blood samples without compromising the accuracy and efficacy of diagnosing diseases or identifying specific particulates from those blood samples.

Abstract: The present invention provides centrifuges (e.g., analytical centrifuges) comprising a cooling assembly having a cooling surface disposed inside the centrifuge chamber and spaced apart from the rotor. The cooling surface disposed inside the centrifuge chamber, spaced apart from the rotor, and configured to exchange heat between the cooling assembly and the rotor, the thermal element thermally coupled to the cooling surface, and configured to control the temperature of the cooling surface.

Abstract: Embodiments of lab automation workstations are disclosed in which the pod that performs pipetting operations is integrated with pipette tip-loading functionality. To generate the necessary tip-loading force, a dual drive system is used that is symmetric about the Y-axis to allow for offset or partial tip box loads by dynamically centering the drive force (e.g., the tip-loading force) over the reaction load. This minimizes the need for oversized linear motion components while still allowing for the generation of high tip-loading forces needed to properly load a large number of pipette tips simultaneously.

Abstract: Embodiments may include an automated method for evaluating a sepsis status associated with a blood sample obtained from an individual. Methods may include determining a standard deviation of monocyte volume associated with the blood sample. Methods may include determining a white blood cell count (WBC) associated with the blood sample. Methods may include evaluating, using a data processing module, the sepsis status associated with the blood sample. The data processing module may include a processor and a computer application. This computer application may cause the processor to compare the standard deviation of monocyte volume with a first cutoff value to provide a comparison. The computer application may cause the processor to compare the WBC to a second cutoff to provide a second comparison. The computer application may also cause the processor to evaluate the sepsis status associated with the blood sample based on the first comparison and the second comparison.

Abstract: The disclosure relates to methods and apparatus for processing fluids through the use of a magnetic assembly wherein the magnetic assembly includes at least one fluid chamber containing a fluid and magnetic particles.

Abstract: The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.

Abstract: The present disclosure relates to a fluid system for a sample processor and a sample processor including the fluid system. The fluid system includes a sample line, a processing fluid line, a vacuum line, and an air pump. The sample line communicates a sample container with a sample port of a flow cell unit. The processing fluid line communicates a sheath fluid container with a processing fluid port of the flow cell unit. The vacuum line is in communication with the flow cell unit. The air pump includes a first output port and a second output port. Pressurized gas is generated at the first output port, and the first output port is in communication with the sample container and the sheath fluid container. A vacuum is generated at the second output port, and the second output port is in communication with a vacuum port of the flow cell unit through the vacuum line.

Abstract: One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component.