Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving tip including mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes at least one thread on inner surface of its sidewall that does not correspond to the mating feature of needleless connector, but is sufficient to interlock with mating feature of needleless connector. Plurality of disinfection caps are disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.

Abstract: A dual chamber, sequential delivery syringe facilitates selective drug mixing, dosing, and administration through catheters or other vascular accessing devices (VADs), as well as post-administration flushing of catheters with a single syringe instrument. A syringe barrel incorporates an outlet, such as a Luer connector, a variable-volume, primary fluid chamber, and a secondary chamber that is pre-filled with fluid. A plunger manipulated, telescoping actuator, in conjunction with a medication stopper disposed within the barrel interior, form a valve for selectively isolating the secondary fluid chamber from fluid communication with the primary fluid chamber and/or the outlet of the syringe barrel. Valve opening is accomplished automatically by continuous advancement of the plunger.

Abstract: A vial adapter includes a body having a component connection interface and a vial connection interface, with the component connection interface configured to engage a connection interface of a mating component, a pressure equalization assembly including a chamber configured to expand from a first volume to a second volume larger than the first volume, and a piercing member having a first end connected to the body and a second end positioned opposite the first end. The second end of the piercing member includes a piercing point configured to pierce a closure of a vial, with the first and second fluid ports extending from a position intermediate the first and second ends of the piercing member to the second end of the piercing member. The first and second fluid ports and a portion of the piercing member define a V-shaped profile at the second end of the piercing member.

Abstract: Systems and methods for imaging and image-based analysis of test devices can include a background device for a lateral flow assay test strip. In one aspect, the background device can include a test strip portion sized and shaped to guide placement, on the background device, of the lateral flow assay test strip; a background portion at least partially surrounding the test strip portion; and one or more features of the background portion. The one or more features can include line detection fiducials, position fiducials, modulation transfer function fiducials, motion blur detection fiducials, and/or RGB balanced areas for evaluation of lighting conditions.

Abstract: A biological liquid collection device designed to draw blood using an “atmospheric-balanced vacuum” to ensure the blood is exposed to the sample atmospheric partial pressure oxygen and partial pressure carbon dioxide levels as found in standard arterial blood gas syringes, resulting in blood gas sample stabilization during collection and a superior vacuum shelf-life by reducing the gas permeation rate through the plastic tube. The biological liquid collection device comprises a collection module for receiving a biological liquid sample, an evacuated container having an open end and a closed end wherein the evacuated container contains the collection module therein, and a closure for closing the open end of the evacuated container. The evacuated container comprises a gas composition that is substantially equal to the gas composition of the atmosphere outside of the evacuated container. A method for forming the atmospherically balanced vacuum collection device is also provided.

Abstract: Methods for characterizing spillover spreading originating from a first fluorochrome in fluorescent flow cytometer data collected for a second fluorochrome are provided. In some embodiments, methods include partitioning the fluorescent flow cytometer data according to the intensity of the data relative to the first fluorochrome. In embodiments, methods also include estimating with a first linear regression a zero-adjusted standard deviation for the intensity of light collected from the second fluorochrome for each of the partitioned quantiles based on the assumption that the intensity of light collected from the first fluorochrome is zero, and obtaining with a second linear regression a spillover spreading coefficient from the zero-adjusted standard deviations. Systems and computer-readable media for characterizing spillover spreading originating from a first fluorochrome in fluorescent flow cytometer data collected for a second fluorochrome are also provided.

Abstract: Water soluble polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers including branched non-ionic water soluble groups (WSG) comprising two or more water soluble polymers. In some cases, the branched non-ionic water soluble groups (WSG) of the present disclosure are capable of imparting solubility in water in excess of 50 mg/mL to the multichromophore. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are aggregation-resistant labelled specific binding members that include the subject water soluble polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

Abstract: Aspects of the present disclosure include methods for characterizing particles of a sample in a flow stream. Methods according to certain embodiments include detecting light from a sample having cells in a flow stream, generating an image of an object in the flow stream in an interrogation region and determining whether the object in the flow stream is an aggregate based on the generated image. Systems having a processor with memory operably coupled to the processor having instructions stored thereon, which when executed by the processor, cause the processor to generate an image of an object in a flow stream and to determine whether the object is an aggregate are also described. Integrated circuit devices (e.g., field programmable gate arrays) having programming for practicing the subject methods are also provided.

Abstract: A syringe adapter includes a housing, a cannula having a first end and a second end with the second end of the cannula positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway with a membrane received by the passageway. The collet includes a locking member connected to the body of the collet. The membrane includes a body having a first end and a second end with the collet movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted. The passageway of the body of the collet includes a narrowed portion configured to compress a portion of the body of the membrane.

Abstract: A system for capture of dose delivery information is provided. The system includes a medication delivery device, a dose information capture device adapted to be attached to the medication delivery device, and a target element adapted to be attached to the medication delivery device. The target element comprises a magnet or ferrous element and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device. The dose information capture device includes a magnetic position sensor adapted to detect a position of the target element. As an alternative to magnetic sensing, MEMS flow sensors, and the like may also be used. Exemplary systems preferably transmit dose information in real time to remote devices for further processing.

Abstract: A wearable medical device (e.g., wearable drug delivery pump) sends a request to another device for generation of an audible or vibratory notification at the other device, which is helpful when the wearable medical device is obscured by a user's clothing or the user is vision or hearing impaired. The other device receiving the request to generate a notification can be a remote controller or smartphone paired with the wearable medical device, or a smart watch or a Bluetooth (BT)-enabled headset or other device paired with the remote controller. The wearable medical device is configured with a BT stack that allows the device to pair with its controller in a secure bonded relationship, but to send signals requiring less security (e.g., requests for generation of notifications) to other devices (e.g., a BT-enabled headset or smart watch) using a more ubiquitous wireless protocol such as a standard BT protocol with broadcast mode.

Abstract: A syringe is provided. The syringe includes a syringe barrel including an open proximal end, a closed distal end, and a sidewall extending therebetween. The syringe also includes: a plunger having an annular sidewall configured to seal against an interior surface of the sidewall of the syringe barrel, the plunger being configured to move through the syringe barrel in proximal and distal directions; a pump in fluid communication with an interior volume of the syringe barrel, the pump being configured to draw fluid from the syringe barrel; and a nozzle including a lumen in fluid communication with the pump and configured to receive fluid drawn from the syringe barrel by the pump and to expel the fluid through a distal end of the lumen. The pump can be a valve-less piston pump.

Abstract: A needle protection device may include a hub, a housing disposed within the lumen of the hub, and a needle. The housing may include a tubular portion, which may include two arms coupled thereto. Each of the arms may include a first end coupled to the tubular portion, a second end disposed within the tubular portion, and a bent portion therebetween. The second end of the first arm and the second end of the second arm may form a duckbill valve. A needle may extend through the housing. Withdrawing a sharp distal tip of the needle in a proximal direction beyond the second end of each of the arms may close the duckbill valve and facilitate removal of the housing from the hub. Shielding the sharp distal tip of the needle in this manner may prevent blood spatter and exposure to blood and blood-borne pathogens.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger, and plunger driver assembly comprising double-acting, telescoping lead screws that is located behind and outside of the barrel. Simultaneously and counter-rotating sleeve screw and center screw telescope out of a nested configuration of the plunger driver assembly and into the reservoir at a rate of double their individual and equal pitch and lead parameters when the sleeve screw is rotated. A threaded nut and gear anchor disposed on an end of the barrel receive the sleeve screw and the threaded nut causes the sleeve screw to translate and rotate in response to motor operation. A distal end of the center screw can be keyed to a plunger pusher for anti-rotation constraint when the motor is imparting rotation on the threaded nut and sleeve screw.

Abstract: Methods of assembling a controller for a commissioning device are provided. A method includes extending a delivery table in a first horizontal direction, the delivery table having a storage end and a retrieval end, disposing two elongated clamping jaws above the delivery table, extending, in a second horizontal direction perpendicular to the first horizontal direction, a first guide and a second guide that are parallel and spaced from one another in the first horizontal direction, coupling at least four clamping jaw carriages to the first and second guides, wherein at least two clamping jaw carriages separated from one another in the first horizontal direction are coupled to a single clamping jaw, respectively, and coupling at least four drive elements to a clamping jaw drive unit.

Abstract: An infusion system having an integrated inserter and infusion set (10) for containing and placing a flexible catheter (40), and a retractable introducer needle (26), wherein the catheter (40) is isolated from movement after placement. The integrated inserter and infusion set (10) includes a hub (20), having a user push button (30) to activate the device for catheter (40) placement. An adhesive liner (34) can be provided to cover an adhesive layer (36), such as pressure sensitive adhesive (PSA), on the bottom of the device (10).

Abstract: An imaging module to obtain an image of an entire bottle in one image frame. The imaging module places the bottle in an auxiliary mirror module (AMM). The module has a quasi-conical shaped mirror which offers a reflection of the bottle placed in the AMM. That reflection is the source of an image obtained by an imaging assembly. The imaging assembly can be a lens/camera assembly or a photo sensor that will detect photo fluorescence.

Abstract: A dual chamber syringe facilitates selective drug mixing, dosing, and administration, as well as pre- or post-administration flushing with a single syringe instrument. A syringe barrel incorporates an outlet, as well as variable-volume, primary and secondary fluid chambers, separated by a floating stopper. The floating stopper defines a dome-shaped split septum with a central slit at its apex. The split septum is a bi-stable valve, closing the central slit by compression in its meridial dimension when the septum is in a first, relaxed state, and opening the central slit when the septum is buckled or flipped under tension in the meridial dimension in a second state. Buckling of the septum wall is caused solely by differential fluid pressure applied by a single plunger, without physical contact of the septum with any other structure within the syringe.

Abstract: Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.

Abstract: Capillary-based pressure threshold sensors are provided for liquids that exploit the properties of hydrophobic, superhydrophobic, oleophobic and amphiphobic porous membranes to detect when fluid passes through the membrane in the event of the pressure across the membrane rising above the breakthrough pressure of a fluid. Example implementations are provided of different configurations for a capillary-based pressure threshold sensor, and of how a capillary-based pressure threshold sensor is used in a medication delivery device or other fluid delivery devices to detect occlusion or other fluid flow condition.