Abstract: A catheter system may include a catheter adapter having a distal end, a proximal end, and a lumen extending therebetween. The system may include a catheter tube extending distally from the catheter adapter. The system may include an extension tube coupled to the proximal end of the catheter adapter. The extension tube may be extendable. The system may include a locking mechanism coupled to the extension tube and removably coupled to the proximal end of the catheter adapter. The system may include a needle hub removably coupled to a proximal end of the extension tube and an introducer needle extending through the catheter tube. A proximal end of the introducer needle may be secured within the needle hub.

Abstract: Aspects of the present disclosure include methods for flow cytometrically sorting a sample with particles, such as cells, based on order of identification. Methods according to certain embodiments include introducing the sample into a flow cytometer; flowing the introduced sample in a flow stream; irradiating the sample in the flow stream with a light source; detecting light from cells in the sample flowing in the flow stream; identifying phenotypes of cells in the sample flowing in the flow stream based on one or more data signals generated from the detected light; and dynamically sorting into partitions cells of the sample that have a phenotype of a collection of predetermined phenotypes based on order of identification. Systems for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.

Abstract: Packages comprising a film surrounding the medical device are described and including a tear-enabling feature and a gripping feature enabling a user to use a finger, a thumb or an end of a tool to apply a sufficient tearing force to cause the tear-enabling feature to tear and move the first end of the package away from the second end of the package using only one hand and to expose the medical device to be accessed for use. Also described are methods of packaging a medical device.

Abstract: A catheter assembly may include a cannula. The cannula may include a distal tip, an elongated tubular shaft, and an inner lumen formed by the elongated tubular shaft. A first portion of the elongated tubular shaft may have a first outer diameter. The first portion may be proximate the distal tip. A second portion of the elongated tubular shaft may have a second outer diameter. The second outer diameter may be greater than the first outer diameter. The catheter assembly may also include a catheter adapter, which may include a catheter and a catheter hub. The second portion of the elongated tubular shaft may be at least partially disposed in the catheter hub.

Abstract: Disclosed herein include systems, methods, compositions, and kits for determining protein expression and gene expression simultaneously and for sample indexing. In some embodiments, an oligonucleotide associated with a cellular component-binding reagent (e.g., an antibody) comprises one or more of a unique molecular label sequence, a primer adapter, antibody-specific barcode sequence, an alignment sequence, and/or a poly(A) sequence. In some embodiments, the oligonucleotide is associated with the cellular component-binding reagent via a linker (e.g., 5AmMC12).

Abstract: Disclosed herein include systems, methods, compositions, and kits for immune repertoire profiling. There are provided, in some embodiments, primer panels enabling the determination of the nucleotide sequence of the complete variable region of nucleic acids encoding mouse B cell receptor (BCR) and T cell receptor (TCR) polypeptides. In some embodiments, the method comprises single cell transcriptomic analysis.

Abstract: Aspects of the present disclosure include methods for identifying one or more components of a sample in a flow stream using a dynamic algorithm (e.g., a machine learning algorithm). Methods according to certain embodiments include detecting light from a sample having particles in a flow stream, generating a data signal of parameters of the particles from the detected light, generating an image based on the data signal, comparing the image with one or more image classification parameters and classifying one or more components of the image using a dynamic algorithm that updates the image classification parameters based on the classified components in the image. Systems and integrated circuit devices programmed for practicing the subject methods, such as on a flow cytometer, are also provided.

Abstract: A medication filling device and system are provided. The filling device is configured to attach to a medication delivery device and includes a vial attachment component configured to attach to a medication vial. The vial attachment component includes a pump, operable in forward and reverse directions, and an empty vial detection unit configured to detect whether a vial attached to the vial attachment component is empty. The filling device further includes a processor configured to receive a signal from the empty vial detection unit indicating whether a vial attached to the vial attachment component is empty, and a user interface configured to output an indication to a user indicating whether the vial is empty.

Abstract: A medical device operable to deliver a fluid to a patient, including a base having a base body and a hollow cannula for insertion into a patient, the hollow cannula being one of fixed to the base and movable relative to the base to a patient insertion position. The base body includes a fluid pathway that is one of fluidly connected with the hollow cannula and fluidly connectable with the hollow cannula. The fluid pathway includes a pathway portion sealed with a sealer, and the pathway portion includes an adsorbent operable to modify a fluid traversing the pathway portion by removing one or more compounds or substances from the fluid prior to delivery of the fluid to the patient through the hollow cannula.

Abstract: Medical articles formed from a polyurethane-based resin including a modifying oligomer provide enhanced properties. A modifying oligomer incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by a diisocyanate, a polyglycol, and a diol chain extender has at least one, preferably two, alcohol moieties (C—OH) and a functional moiety. Exemplary modifying oligomers are: a diol-containing perfluoropolyether incorporated into the backbone, a monofunctional polysiloxane (e.g., monodialcohol-terminated polydimethylsiloxane) incorporated as the side chain, and combinations thereof. Medical articles herein are self-lubricating and/or anti-fouling.

Abstract: Insulin injection syringes are disclosed that include two types of components, namely, durable components that that do not contact the fluid path and can be reused, and disposable or single-use components that contact the fluid path and are not reused. The durable components do not contact the fluid path so that sterility is not affected. Two different syringe components include a reusable outer sleeve containing scale markings for the syringe and a reusable syringe plunger are provided as durable components in embodiments of the present invention. Syringes manufactured according to the present invention can employ one or both of these durable components. Methods for making, using and packaging such syringes are also disclosed.

Abstract: Medical devices capable of filling liquid into a syringe barrel while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel having a tapered sidewall portion for permitting air to vent from the chamber and preventing liquid from exiting the chamber, a plunger rod, and stopper. Another exemplary medical device includes a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel, a plunger rod and stopper. Also described is a medical device including a syringe barrel, plunger rod and stopper having a porous plug. Described is a medical device including a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel and a porous membrane disposed over the air venting grooves, a plunger rod and stopper. Methods for filling a syringe barrel with a liquid are also provided.

Abstract: A needle actuator assembly for a drug delivery system includes a needle actuator body having a guide surface, a needle shuttle having a cam surface, with the needle shuttle moveable along a vertical axis between a first position and a second position. The needle shuttle is configured to move between the first and second position through engagement between the guide surface of the needle actuator body and the cam surface of the needle shuttle. The assembly further including a needle received by the needle shuttle.

Abstract: Methods and systems for determining a drop delay of a flow stream in a flow cytometer are provided. Aspects of the methods according to certain embodiments include capturing an image of the flow stream to obtain an imaged flow stream, identifying a disturbance at a break off point in the imaged flow stream and calculating the drop delay of the flow stream based on the identified disturbance. Systems for practicing the subject methods having an imaging sensor for capturing one or more images of the flow stream and a processor configured to identify a disturbance at a break off in the imaged flow stream and calculating the drop delay using the imaged flow stream are also provided. Non-transitory computer readable storage mediums are also described.

Abstract: Components of medical devices include polypropylene-poly(ethylene oxide) amphiphilic graft copolymers (PP-g-PEO) in their base polymer formulations. The base polymeric formulations comprise at least a polymer or co-polymer of propylene. These components are suitable for solvent-bonding with other components and enhance bond strength of the medical devices.

Abstract: Disclosed herein include systems, methods, compositions, and kits for determining expressions of proteins and genes simultaneously, and for sample indexing. The method can comprise extending a cellular component-binding reagent specific oligonucleotide hybridized to an oligonucleotide barcode to generate an extended cellular component-binding reagent specific oligonucleotide. The extended cellular component-binding reagent specific oligonucleotide can be separated from the oligonucleotide barcodes. The separated extended cellular component-binding reagent specific oligonucleotide can be amplified separately from barcoded cDNA.

Abstract: Components of medical devices include polyethylene-poly(ethylene oxide) amphiphilic graft copolymers (PE-g-PEO) in their base polymer formulations. The base polymeric formulations comprise at least a polymer or co-polymer of ethylene. These components are suitable for solvent-bonding with other components and enhance bond strength of the medical devices.

Abstract: Drug delivery safety devices having trigger activation systems activated by pressure against the skin of a patient and which automatically shield the needle after withdrawing the needle from the skin of the patient.

Abstract: A closure and a container assembly are disclosed. The closure includes a first visual identifier and a second visual identifier, wherein the second visual identifier is different from the first visual identifier. The first visual identifier may be a first color, and the second visual identifier may be a second color. At least one of the first and/or second visual identifier may include a fluorescent compound having a characteristic fluorescent spectra. The first visual identifier and the second visual identifier may be provided on the annular skirt of the closure. The fluorescent compound may be provided on at least one of the closure and the container assembly and can be used to facilitate automated visualization of the fluorescent compound under fluorescence excitation light.

Abstract: Water solvated polymeric dyes and polymeric tandem dyes are provided. The polymeric dyes include a water solvated light harvesting multichromophore having a conjugated segment of aryl or heteroaryl co-monomers linked via covalent bonds, vinylene groups or ethynylene groups. The polymeric tandem dyes further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labeled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labeling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.