Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: A vascular access system which may be configured for blood draw may include a housing, which may include a distal end, a proximal end, and a slot disposed between the distal end and the proximal end. The slot may include a notch. The vascular access system may include a cannula hub, which may be disposed within the housing and movable with respect to the slot. The cannula hub may include a tab extending through the slot. The vascular access system may include a cannula extending distally from the cannula hub. In response to the tab being disposed within the notch, a distal tip of the cannula may be disposed within the housing. In response to advancing the tab along the slot to a distal end of the slot, the distal tip of the cannula is disposed distal to the distal end of the housing.

Abstract: Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.

Abstract: An introducer needle may include a proximal end, a distal tip, and a needle lumen extending therebetween. The introducer needle may include a wall defining the needle lumen, a first notch formed through the wall, and a second notch formed through the wall. A catheter system may include a catheter adapter, a catheter extending distally from the distal end of the catheter adapter, a flash chamber coupled to the introducer needle, and the introducer needle, which may extend through the catheter. The first and second notches and the flash chamber may facilitate pressure-driven blood flow into the catheter for improved flashback and detection of transfixation when the catheter is primed prior to insertion into vasculature of a patient or otherwise.

Abstract: A smart syringe system and method are provided. The system includes a smart syringe and an external device. The syringe obtains data of a dose administered to a patient and wirelessly transmit the data to the external device. Alternately, the external device obtains the data via an image of the syringe. The external device may execute an application configured to process the data and display information of the dose.

Abstract: An injection pen, comprising a housing, a lead screw axially moveable in the housing, a dose set member for dose setting and dose correcting, threadably connected to the housing and having a first mating feature, a setback member having a second mating feature for engaging the first mating feature, a clicker that generates an audible or tactile indication during operation, the clicker being operatively connected to the dose set member, and a push button operatively connected to the setback member to cause the second mating feature to engage the first mating feature during an injection, the push button receiving the clicker, wherein the first mating feature is disengaged from the second mating feature during dose setting and dose correcting and engaged with the second mating feature during an injection.

Abstract: A drug delivery device system with mutable indicia and method for using same are provided. The drug delivery device system includes a syringe and/or syringe components (e.g., needle shield, needle guard), or autoinjector pen, or wearable autoinjector with mutable indicia and a software application for an external device to analyze images of the mutable indicia to automatically determine and record status of the drug delivery device. The mutable indicia or codes on the drug delivery device or its components represent different medical events such as dose completion, dose amount, and safety feature deployment or removal and can be detected by and otherwise logged by the external device. The external device may execute an application configured to further process data obtained via captured images of mutable indicia and display related information (e.g., fluid remaining in syringe barrel, delivered dose, and so on).

Abstract: Medical articles formed from ionically bonding an ionic polymer and an active agent provide enhanced properties. The ionic polymer may be one or more of an anionic polymer, a cationic polymer, and a zwitterionic polymer. The device may also include a nonionic polymer. Medical articles herein have antimicrobial, anti-fouling, and/or antithrombotic characteristics.

Abstract: Medical articles formed from ionically bonding an ionic polymer and an active agent provide enhanced properties. The ionic polymer may be one or more of an anionic polymer, a cationic polymer, and a zwitterionic polymer. The device may also include a nonionic polymer. Medical articles herein have antimicrobial, anti-fouling, and/or antithrombotic characteristics.

Abstract: Disclosed herein include systems, methods, compositions, and kits for determining protein expression and gene expression simultaneously and for sample indexing. In some embodiments, an oligonucleotide associated with a cellular component-binding reagent (e.g., an antibody) comprises one or more of a unique molecular label sequence, a primer adapter, antibody-specific barcode sequence, an alignment sequence, and/or a poly(A) sequence. In some embodiments, the oligonucleotide is associated with the cellular component-binding reagent via a linker (e.g., 5AmMC12).

Abstract: Packages comprising a film surrounding the medical device are described and including a tear-enabling feature and a gripping feature enabling a user to use a finger, a thumb or an end of a tool to apply a sufficient tearing force to cause the tear-enabling feature to tear and move the first end of the package away from the second end of the package using only one hand and to expose the medical device to be accessed for use. Also described are methods of packaging a medical device.

Abstract: A catheter system may include a catheter adapter having a distal end, a proximal end, and a lumen extending therebetween. The system may include a catheter tube extending distally from the catheter adapter. The system may include an extension tube coupled to the proximal end of the catheter adapter. The extension tube may be extendable. The system may include a locking mechanism coupled to the extension tube and removably coupled to the proximal end of the catheter adapter. The system may include a needle hub removably coupled to a proximal end of the extension tube and an introducer needle extending through the catheter tube. A proximal end of the introducer needle may be secured within the needle hub.

Abstract: Disclosed herein include systems, methods, compositions, and kits for immune repertoire profiling. There are provided, in some embodiments, primer panels enabling the determination of the nucleotide sequence of the complete variable region of nucleic acids encoding mouse B cell receptor (BCR) and T cell receptor (TCR) polypeptides. In some embodiments, the method comprises single cell transcriptomic analysis.

Abstract: Aspects of the present disclosure include methods for identifying one or more components of a sample in a flow stream using a dynamic algorithm (e.g., a machine learning algorithm). Methods according to certain embodiments include detecting light from a sample having particles in a flow stream, generating a data signal of parameters of the particles from the detected light, generating an image based on the data signal, comparing the image with one or more image classification parameters and classifying one or more components of the image using a dynamic algorithm that updates the image classification parameters based on the classified components in the image. Systems and integrated circuit devices programmed for practicing the subject methods, such as on a flow cytometer, are also provided.

Abstract: A catheter assembly may include a cannula. The cannula may include a distal tip, an elongated tubular shaft, and an inner lumen formed by the elongated tubular shaft. A first portion of the elongated tubular shaft may have a first outer diameter. The first portion may be proximate the distal tip. A second portion of the elongated tubular shaft may have a second outer diameter. The second outer diameter may be greater than the first outer diameter. The catheter assembly may also include a catheter adapter, which may include a catheter and a catheter hub. The second portion of the elongated tubular shaft may be at least partially disposed in the catheter hub.

Abstract: Aspects of the present disclosure include methods for flow cytometrically sorting a sample with particles, such as cells, based on order of identification. Methods according to certain embodiments include introducing the sample into a flow cytometer; flowing the introduced sample in a flow stream; irradiating the sample in the flow stream with a light source; detecting light from cells in the sample flowing in the flow stream; identifying phenotypes of cells in the sample flowing in the flow stream based on one or more data signals generated from the detected light; and dynamically sorting into partitions cells of the sample that have a phenotype of a collection of predetermined phenotypes based on order of identification. Systems for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.

Abstract: A medication filling device and system are provided. The filling device is configured to attach to a medication delivery device and includes a vial attachment component configured to attach to a medication vial. The vial attachment component includes a pump, operable in forward and reverse directions, and an empty vial detection unit configured to detect whether a vial attached to the vial attachment component is empty. The filling device further includes a processor configured to receive a signal from the empty vial detection unit indicating whether a vial attached to the vial attachment component is empty, and a user interface configured to output an indication to a user indicating whether the vial is empty.

Abstract: Medical articles formed from a polyurethane-based resin including a modifying oligomer provide enhanced properties. A modifying oligomer incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by a diisocyanate, a polyglycol, and a diol chain extender has at least one, preferably two, alcohol moieties (C—OH) and a functional moiety. Exemplary modifying oligomers are: a diol-containing perfluoropolyether incorporated into the backbone, a monofunctional polysiloxane (e.g., monodialcohol-terminated polydimethylsiloxane) incorporated as the side chain, and combinations thereof. Medical articles herein are self-lubricating and/or anti-fouling.

Abstract: A medical device operable to deliver a fluid to a patient, including a base having a base body and a hollow cannula for insertion into a patient, the hollow cannula being one of fixed to the base and movable relative to the base to a patient insertion position. The base body includes a fluid pathway that is one of fluidly connected with the hollow cannula and fluidly connectable with the hollow cannula. The fluid pathway includes a pathway portion sealed with a sealer, and the pathway portion includes an adsorbent operable to modify a fluid traversing the pathway portion by removing one or more compounds or substances from the fluid prior to delivery of the fluid to the patient through the hollow cannula.

Abstract: Insulin injection syringes are disclosed that include two types of components, namely, durable components that that do not contact the fluid path and can be reused, and disposable or single-use components that contact the fluid path and are not reused. The durable components do not contact the fluid path so that sterility is not affected. Two different syringe components include a reusable outer sleeve containing scale markings for the syringe and a reusable syringe plunger are provided as durable components in embodiments of the present invention. Syringes manufactured according to the present invention can employ one or both of these durable components. Methods for making, using and packaging such syringes are also disclosed.