Patents Assigned to Becton, Dickinson & Company
  • Methods for determining detector gain in a flow cytometer
    Patent number: 11781964
    Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include determining a background data signal from a photodetector at a plurality of detector gains, irradiating the photodetector with a light source at a plurality of different light intensities, generating data signals from the photodetector for the plurality of light intensities at each detector gain and adjusting the photodetector to the detector gain that corresponds to the lowest light irradiation intensity that generates a data signal resolvable from the background data signal. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: October 10, 2023
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Shreyas Bhaban, Peter Mage
  • Hazardous contaminant collection kit and rapid testing
    Patent number: 11782042
    Abstract: Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection kit provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The kit also provides open and closed fluid transfer mechanism to transfer the collected fluid to a detection device while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: October 10, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Weston F. Harding, Erik K. Witt, Austin Jason Mckinnon, Ray Isaacson, Bart Peterson, Marcel Arantes Souza, Matthew Oshinski
  • Measurement of protein expression using reagents with barcoded oligonucleotide sequences
    Patent number: 11782059
    Abstract: Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: October 10, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Fan, Olaf Zoellner
  • Tube crimping arrangement for drug delivery device
    Patent number: 11779701
    Abstract: A drug delivery system for injecting a medicament is provided. The system includes a container configured to receive a medicament; a drive assembly which, upon actuation, is configured to expel the medicament from the container; a needle for injecting the medicament to a patient; a fluid path assembly comprising a tube in fluid communication with the container and the needle for conducting fluid from the container to the needle; and a tube crimping arrangement configured to engage the tube to block fluid flow through the tube. The drive assembly causes the tube crimping arrangement to engage the tube after a dose of the medicament has been delivered to the patient through the needle.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: October 10, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Jamie Anthony Salter, Oliver Charles Gazeley, David Aubrey Plumptre, James Alexander Senior, Gareth James Lewis, Malcolm Stanley Boyd, Javier Eduardo Nadal
  • Connector for system for closed transfer of fluids
    Patent number: 11779747
    Abstract: A system for closed transfer of fluids includes a syringe adapter including a cannula having a first end and a second end with the second end positioned within the housing, and a seal arrangement positioned within the housing and movable within the housing with the seal arrangement including a membrane. The system including a second component including a membrane and a locking mechanism. The second component configured to be received by the syringe adapter such that the membrane of the seal arrangement engages the membrane of the second component. The locking mechanism including a biasing member and an engagement member positioned on the biasing member, with the engagement member configured to engage a portion of the housing of the syringe adapter to secure the second component to the syringe adapter when the second component is received by the syringe adapter.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: October 10, 2023
    Assignee: Becton Dickinson and Company Limited
    Inventor: Laurie Sanders
  • Flush enhancing male luer tip design for syringes and any luer connector
    Patent number: 11779745
    Abstract: A luer connection device is disclosed having a housing including a side wall having an inside surface defining a lumen with a central axis, an proximal end, and a distal end including a male luer tip within the lumen having a central flow diverter extending outwardly from the central axis to direct a fluid to a circumferential dead space distal to the male luer tip. A luer connection device is also disclosed having a flow expansion channel disposed in the lumen tapering outward from the wall of tubular housing and partially extending along a longitudinal axis from the tip opening toward the base opening for increasing mixing and flow through a circumferential dead space in the fluid path distal to the male luer tip.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: October 10, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Marty L. Stout, Jonathan Karl Burkholz, S. Ray Isaacson
  • Apparatus and method for quantitative characterization of a light detector
    Patent number: 11781963
    Abstract: Aspects of the present disclosure include methods for determining a parameter of a photodetector (e.g., a photodetector in a particle analyzer). Methods according to certain embodiments include irradiating a photodetector positioned in a particle analyzer with a light source (e.g., a continuous wave light source) at a first intensity for a first predetermined time interval, irradiating the photodetector with the light source at a second intensity for a second predetermined time interval, integrating data signals from the photodetector over a period of time that includes the first predetermined interval and the second predetermined interval and determining one or more parameters of the photodetector based on the integrated data signals. Systems (e.g., particle analyzers) having light source and a photodetector for practicing the subject methods are also described.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: October 10, 2023
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Fedor Ilkov, Shreyas Bhaban
  • Catheter assembly
    Patent number: 11779734
    Abstract: A catheter assembly including a catheter carried by a catheter adapter, a needle having a sharp distal tip and disposed in the catheter such that in a first needle position, the needle extending beyond the catheter, a septum actuator having openings, the septum actuator disposed in the catheter adapter and configured to pierce a septum, and a spring clip disposed in the septum actuator and engaging the openings of the septum actuator in the first needle position.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: October 10, 2023
    Assignee: Becton, Dickinson and Company
    Inventor: S. Ray Isaacson
  • ROTATIONAL METERING PUMP FOR INSULIN PATCH
    Publication number: 20230310737
    Abstract: A rotary pump for a fluid metering system is provided. The rotary pump reciprocates, and is reversed by a signal from a limit switch that is deflected by an actuator arm on a rotating sleeve of the pump system.
    Type: Application
    Filed: December 3, 2021
    Publication date: October 5, 2023
    Applicant: Becton, Dickinson and Company
    Inventors: Alessandro Pizzochero, J. Richard Gyory, Kenneth Focht, Justin Fisk, Joseph Gordon, Matthew Perry, Ajit D'Souza, Christopher Petroff
  • Disinfection Device For Female Connectors
    Publication number: 20230310679
    Abstract: A device for connection to a female medical connector is disclosed, the device includes a cap, a scrubbing foam, an elastic sealing lip, and an absorbent material. The cap is configured to define a chamber to contain an absorbent material and disinfectant or antimicrobial agent. The cap may include one or more threads adapted to engage with a female luer connector. The device may also include a peelable seal to maintain sterility prior to use and to prevent the disinfectant or the antimicrobial agent from exiting the chamber prior to use. Also described are methods of disinfecting a medical connector.
    Type: Application
    Filed: March 30, 2022
    Publication date: October 5, 2023
    Applicant: Becton, Dickinson and Company
    Inventors: Manish Kumar, Hemant Vilas Belsare, Praveen Nalawade
  • ROTATIONAL METERING PUMP WITH CAM-DRIVEN VALVING SHUTTLE INTERLOCK
    Publication number: 20230313787
    Abstract: A rotary pump for a fluid metering system is provided. The rotary pump reciprocates, and is reversed by a signal from a limit switch that is deflected by an actuator arm on a rotating sleeve of the pump system. The rotary pump includes a plunger and optional stopper formed from a two-shot molding process, and including seals overmolded onto the head of the plunger and the head of the optional stopper.
    Type: Application
    Filed: September 28, 2021
    Publication date: October 5, 2023
    Applicant: Becton, Dickinson and Company
    Inventor: Alessandro E. PIZZOCHERO
  • Device for the attached flow of blood
    Patent number: 11771352
    Abstract: A collection device (10) which directs a flow of blood into a container (14) and provides a controlled blood flow path that ensures blood flow from a collection site to a collection container is disclosed.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: October 3, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Kishore K. Bokka Srinivasa Rao, Jayeon Kim, Milan Ivosevic
  • Cell sorting using a high throughput fluorescence flow cytometer
    Patent number: 11774343
    Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: October 3, 2023
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Eric D. Diebold, Keegan Owsley, Jonathan Lin
  • Catheter adapters
    Patent number: 11771882
    Abstract: A catheter adapter may include a catheter adapter body and a catheter adapter channel formed within the catheter adapter body. The catheter adapter body may include a proximal end, a distal end, an inferior surface, and a superior surface. The inferior surface of the catheter adapter body may be configured to abut against a surface area of a patient's skin, and an angle formed between the surface area of the patient's skin and a longitudinal axis of the catheter adapter channel may be greater than 4 degrees.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: October 3, 2023
    Assignee: Becton, Dickinson and Company
    Inventor: Joseph Spataro
  • Force sensing resistor for liquid low-volume detection and occlusion sensing and methods and apparatuses for flow sensing along fluid path in fluid delivery device
    Patent number: 11771824
    Abstract: A system and method is provided for detecting fluid low-volume and occlusion in a device using force sensing resistor (FSR) sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: October 3, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Alessandro Pizzochero, J. Richard Gyory, Joseph Iskandar
  • Method of sample preparation for maldi and automated system therefor
    Patent number: 11774332
    Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: October 3, 2023
    Assignee: BECTON DICKINSON AND COMPANY
    Inventors: Timothy Wiles, John D. Mantlo
  • High throughput multiomics sample analysis
    Patent number: 11773441
    Abstract: Disclosed herein include systems, methods, compositions, and kits for sample analysis. Nucleic acid fragments comprising a capture sequence (or a complement thereof) can be generated from double-stranded genomic deoxyribonucleic acid (gDNA), barcoded to generate single-stranded DNA (ssDNA) fragments, and sequenced. Information relating to the gDNA (e.g., genome, chromatin accessibility, methylome) can be determined based on the sequences of the ssDNA fragments in the sequencing data obtained.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: October 3, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Fan, Elisabeth Marie Walczak
  • Using random priming to obtain full-length V(D)J information for immune repertoire sequencing
    Patent number: 11773436
    Abstract: Disclosed herein include systems, methods, compositions, and kits for labeling nucleic acid targets in a sample. In some embodiments, nucleic acid targets (e.g., mRNAs) are initially barcoded on the 3? end and are subsequently barcoded on the 5? end following a template switching reaction and intermolecular and/or intramolecular hybridization and extension. 5?- and/or 3?-barcoded nucleic acid targets can serve as templates for amplification reactions and/or random priming and extension reactions to generate a sequencing library. The method can comprise generating a full-length sequence of the nucleic acid target by aligning a plurality of sequencing reads. Immune repertoire profiling methods are also provided in some embodiments.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: October 3, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Chang, Margaret Nakamoto
  • Assay for by amplification and detection of AP65-1 gene
    Patent number: 11773457
    Abstract: A region of the Trichomonas vaginalis AP65-1 gene has been identified which is useful for performing amplification assays to determine specifically whether T. vaginalis is present in the sample being tested. Oligonucleotides useful for performing thermal Strand Displacement Assay (tSDA) reactions on this gene are disclosed. The disclosed oligonucleotides can be used in an assay which is specific for multiple strains of T. vaginalis and which does not show cross reactivity with the genomes of other microorganisms or with human DNA.
    Type: Grant
    Filed: August 21, 2021
    Date of Patent: October 3, 2023
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventor: Ray A. McMillian
  • Disinfection Cap
    Publication number: 20230293750
    Abstract: A disinfection cap for a male medical connector comprising a housing, a scrubbing foam having a plurality of slits disposed within a first cavity of the housing, a central post extending from the closed bottom of the housing and positioned within the first cavity of the housing, a foam jacket disposed on the central post and having a plurality of slits; and a central plug disposed in the center of the central post extending from the top wall of the central post and extending into the second cavity of the foam jacket. The inner surface of the foam jacket defines a second cavity.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 21, 2023
    Applicant: Becton, Dickinson and Company
    Inventors: Balaji Kannan, Karthik MR, Prasad Govindaraj, Manish Kumar