Patents Assigned to Beecham Group p.l.c.
  • Patent number: 5449509
    Abstract: An oral hygiene composition for use in the treatment of dentine hypersensitivity comprises a water soluble strontium salt and a water soluble potassium salt, together with a dentally acceptable excipient. Preferably, the composition is in the form of a dentifrice comprising an abrasive silica and a thickening silica, and optionally includes an ionic fluorine-containing compound.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: September 12, 1995
    Assignee: Beecham Group p.l.c.
    Inventors: Robert J. Jackson, Susan A. Duke, Mark A. Wicks
  • Patent number: 5436266
    Abstract: Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: July 25, 1995
    Assignee: Beecham Group p.l.c.
    Inventors: Geoffrey H. Baker, Merle Beal
  • Patent number: 5384112
    Abstract: A partially neutralized aluminium salt, wherein at least 25% of the total aluminium is present in a form which has a Relative Retention Time (as hereinbefore defined) in the range 0.82 to 0.91 and/or an .sup.27 Al NMR spectrum wherein 8% to 25% of the total area under the spectrum from 140 ppm to -80 ppm is contained in a peak at approximately 63 ppm, is new and useful as an antiperspirant compound.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: January 24, 1995
    Assignee: Beecham Group p.l.c.
    Inventor: Quinten R. M. Clarkson
  • Patent number: 5371092
    Abstract: The method of using paroxetine or a pharmaceutically acceptable salt thereof for the treatment of senile dementia.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: December 6, 1994
    Assignee: Beecham Group, p.l.c.
    Inventor: Anthony M. Johnson
  • Patent number: 5362739
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 represents ##STR2## and the remainder of the variables are defined in the specification are useful in the treatment and/or prophylaxis of dementia in mammals.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: November 8, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Barry S. Orlek, Steven M. Bromidge, Richard E. Faulkner, deceased
  • Patent number: 5356886
    Abstract: The present invention provides antiviral compounds of Formula (I), and pharmaceutically acceptable salts thereof: ##STR1## wherein X is --CH.sub.2 O or --CH.sub.2 ;R.sub.1 is hydroxy or amino;R.sub.2 is hydrogen or amino;R.sub.3 is hydrogen, hydroxymethyl or acyloxymethyl, wherein the acyl group of said acyloxymethyl is selected from the group consisting of C.sub.1-7 alkanoyl and benzoyl optionally substituted in the phenyl ring by one, two or three substituents selected from the group consisting of fluoro, chloro, bromo, C.sub.1-4 alkyl and C.sub.1-4 alkoxy, wherein the alkyl moiety of said C.sub.1-4 alkyl and C.sub.1-4 alkoxy substituents is selected from the group consisting of methyl, ethyl, n- and iso-propyl, n-, sec-, iso- and tert-butyl,R.sub.4 is a group of formula: ##STR2## wherein R.sub.5 and R.sub.6 are independent selected from hydrogen, C.sub.1-6 alkyl and phenyl optionally substituted by one, two or three substituents selected from the group consisting of fluoro, chloro, bromo, C.sub.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: October 18, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Michael R. Harnden, Martin J. Parratt
  • Patent number: 5356914
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 represents a 1,2,5,6-tetrahydropyridin-3-yl group N-substituted by R.sub.10 wherein R.sub.10 represents OH; a group hydrolysable in vivo to OH or hydrogen; C.sub.1-8 alkoxy; C.sub.2-8 alkenyloxy; C.sub.2-8 alkynyloxy; C.sub.3-8 cycloalkyloxy; or COR.sub.13 wherein R.sub.13 represents hydrogen, C.sub.1-8 alkyl, phenyl or phenyl C.sub.1-4 alkyl; in which any phenyl moiety is optionally substituted by up to 3 substituents independently selected from C.sub.1-6 alkoxy, C.sub.1-6 alkyl, halo, C.sub.1-6 alkoxycarbonyl, cyano, C.sub.1-6 alkylthio or C.sub.1-6 alkylsulphonyl; enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia in mammals.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: October 18, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Steven M. Bromidge, Barry S. Orlek, Steven Dabbs
  • Patent number: 5334384
    Abstract: A process for the separation of streptokinase from contaminating proteins in a streptokinase-containing mixture, which comprises treating the mixture with a reducing agent to reduce disulphide bridges in the contaminating proteins to free thiol groups, contacting the mixture with a reagent R-X wherein R is a group capable of reacting with a free thiol group and X is a group R.sup.1 capable of reacting with a free thiol group or is a thiol-containing matrix, and thereafter separating the resulting chemically modified contaminating proteins from the mixture to provide streptokinase in a form substantially free of contaminating proteins.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: August 2, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Christopher J. Mannix, Richard A. G. Smith, Ceri J. Lewis, Julian S. Harber
  • Patent number: 5328922
    Abstract: A class of compounds identified as N-(1-methyl-1H-indol-5-yl)-(2,3 or 4-pyridyl)ureas, derivatives thereof, methods for their preparation, pharmaceutical compositions containing same and their 5-HT receptor antagonist activity are believed to be of potential use in the treatment of a variety of CNS disorders are described herein.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: July 12, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Ian T. Forbes, Roger T. Martin
  • Patent number: 5324724
    Abstract: Azabicyclic compounds, processes for their preparation and their use in the treatment and/or prophylaxis of dementia in animals.
    Type: Grant
    Filed: September 1, 1992
    Date of Patent: June 28, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Barry S. Orlek, Richard E. Faulkner
  • Patent number: 5322951
    Abstract: An intermediate compound of Formula (V): ##STR1## wherein G is COQ.sub.1 and Q.sub.1 represents chloro, bromo, C.sub.1-4 alkoxy, PhO--, Cl.sub.5 C.sub.6 O--, Cl.sub.3 CO--, succinimidyloxy or imidazolyloxy; the remainder of the terms R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and Y are defined in the specification. The intermediates of Formula V are useful for preparing 1-(2,3-dihydro-1-carboxamide final products wherein said final products possess 5-HT M-receptor antagonist activity.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: June 21, 1994
    Assignee: Beecham Group, p.l.c.
    Inventors: Francis D. King, Karen A. Joiner
  • Patent number: 5314901
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R.sub.1 represents a 1,2,5,6-tetrahydropyridin-3-yl group N-substituted by R.sub.10 wherein R.sub.10 represents hydrogen, C.sub.1-2 alkyl, prop-2-enyl, prop-2-ynyl or cyclopropyl, R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4, or a group NHR.sub.6, or NR.sub.7 R.sub.8 where R.sub.6, R.sub.7 and R.sub.8 are independently C.sub.1-2 alkyl; and R.sub.3 is chloro, fluoro, bromo, methoxy, C.sub.1-3 alkyl substituted by one, two or three halogen atoms, or R.sub.3 is a group (CH.sub.2).sub.n R.sub.9 where R.sub.9 is --CN, --SH or --SCH.sub.3 and n is 0 or 1, with the proviso that when n is 0, R.sub.9 is not --SH; enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia in mammals.
    Type: Grant
    Filed: February 23, 1993
    Date of Patent: May 24, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Steven M. Bromidge, Barry S. Orlek, Steven Dabbs
  • Patent number: 5310750
    Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1 and R.sup.2 may each represent hydrogen or alkyl providing that at least one of R.sup.1 or R.sup.2 represents alkyl;R.sup.3 and R.sup.4 each represent hydrogen or R.sup.3 and R.sup.4 together represent a bond;n represents an integer 1 or 2;and m represents an integer 1 or 2; a composition containing such a compound and the method of using such compounds and compositions in medicine.
    Type: Grant
    Filed: March 1, 1991
    Date of Patent: May 10, 1994
    Assignee: Beecham Group P.L.C.
    Inventors: John M. Berge, Michael A. Cawthorne
  • Patent number: 5278170
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 represents ##STR2## in which each of p and q independently represents an integer of 2 to 4, r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1;R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4, or a group NHR.sub.6 or NR.sub.7 R.sub.8 where R.sub.6, R.sub.7 and R.sub.8 are independently C.sub.1-2 alkyl; andR.sub.3 is chloro, fluoro, bromo, cyclopropyl, C.sub.1-3 alkyl substituted by one, two or three halogen atoms, or R.sub.3 is a group (CH.sub.2).sub.n R.sub.9 where R.sub.9 is --CN, --OH, --OCH.sub.3, --SH, --SCH.sub.3, --C.tbd.CH or --CH.dbd.CH.sub.2 and n is O or 1, with the proviso that when n is 0, R.sub.9 is not --OH or --SH.
    Type: Grant
    Filed: October 30, 1991
    Date of Patent: January 11, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Barry S. Orlek, Steven M. Bromidge, Steven Dabbs
  • Patent number: 5275816
    Abstract: 7 .alpha.-formamido cephalosporin derivatives having a 3[N-(optionally substituted)aminothiopyridinium thiomethyl] substituent have anti-bacterial activity and are of use in anti-bacterial therapy. Processes for the preparation thereof and intermediates for use in these processes are also disclosed.
    Type: Grant
    Filed: September 4, 1990
    Date of Patent: January 4, 1994
    Assignee: Beecham Group p.l.c.
    Inventors: Clive L. Branch, Angela W. Guest, Stephen C. Finch
  • Patent number: 5264436
    Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein:Z represents a residue of a substituted or unsubstituted aryl group,A.sub.1 represents a substituted or unsubstituted methylene group or a substituted or unsubstituted ethylene group;A.sub.2 represents a substituted or unsubstituted methylene group or a substituted or unsubstituted ethylene group;providing that at least one of A.sup.1 or A.sup.2 represents a substituted methylene group or a substituted ethylene group,X represents O or NR.sup.o wherein R.sup.
    Type: Grant
    Filed: September 16, 1991
    Date of Patent: November 23, 1993
    Assignee: Beecham Group p.l.c.
    Inventors: John M. Berge, Lee J. Beeley
  • Patent number: 5260445
    Abstract: Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein:A.sup.1 represents a substituted or unsubstituted aromatic heterocyclyl group;R.sup.1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group;R.sup.2 and R.sup.3 each represent hydrogen, or R.sup.2 and R.sup.3 together represent a bond;A.sup.2 represents a benzene ring having in total up to five substituents; andn represents an integer in the range of from 2 to 6; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: November 9, 1993
    Assignee: Beecham Group p.l.c.
    Inventor: Richard M. Hindley
  • Patent number: 5254557
    Abstract: A compound of formula (IA) in the form of a pharmaceutically acceptable microfine powder is disclosed.
    Type: Grant
    Filed: June 1, 1992
    Date of Patent: October 19, 1993
    Assignee: Beecham Group p.l.c.
    Inventors: Derek R. Buckle, David G. Smith, Frederick Cassidy
  • Patent number: 5254555
    Abstract: Compounds of the formula (I) or pharmaceutically acceptable salts thereof ##STR1## where R.sub.2 -R.sub.7, Y, a and b are as defined, are useful in the treatment of hypertension and respiratory tract disorders.
    Type: Grant
    Filed: March 19, 1992
    Date of Patent: October 19, 1993
    Assignee: Beecham Group p.l.c.
    Inventors: Geoffrey Stemp, John M. Evans, Gordon Burrell
  • Patent number: 5252575
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; andR.sub.2 is C.sub.1-6 alkyl;which are pro-drugs for 9-(3-hydroxyprop-1-oxy)guanine having antiviral activity, a process for their preparation and their use as pharmaceuticals.
    Type: Grant
    Filed: May 21, 1992
    Date of Patent: October 12, 1993
    Assignee: Beecham Group p.l.c.
    Inventors: Michael R. Harnden, Paul G. Wyatt, Leslie J. A. Jennings