Abstract: This disclosure describes the use of a phosphodiesterase-5 (PDE5) inhibitor to reduce an individual's desire to smoke and/or frequency of smoking. In some embodiments, the PDE5 inhibitor is sildenafil (e.g., Viagra).
Type:
Application
Filed:
November 13, 2020
Publication date:
February 9, 2023
Applicants:
BEHAVIORAL DIAGNOSTICS, LLC, UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Eric A. HOFFMAN, Albert Tao-man LEUNG, Alejandro Comellas, Alicia GERKE, Robert PHILIBERT
Abstract: The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder.