Abstract: The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.

Abstract: The invention relates to a method for forming at least one flat-tube insertion slot in a header tube. A sawcut is introduced into the header tube during a sawing step, and the slot is configured, during a subsequent punching step, by means of a slot punch, which punches into the region of the sawcut. A rimmed opening can be configured during the punching step by using a slot punch with a larger width and/or length relative to the sawcut. The sawcut is preferably introduced to a depth less that the wall thickness of the header tube. The respective web region(s) between chamber of a multi-chamber header tube can be compressed during the punching operation to a level lower than that of a header-tube wall region functioning as a flat-tube insertion stop, in order to form a chamber-connecting duct.

Abstract: In a brazed condenser for an air conditioner, such as a motor vehicle air conditioner, a collecting tube connected with a collector is a prefabricated as a one-piece tube which is connected by tack weld seams with the collector before brazing the collecting tube and the collector together.

Abstract: The invention relates to a heat exchanger for an air-conditioning system (54) of a motor vehicle having a plurality of conducting members (102) for a refrigerant, between which air can flow for heat exchange purposes. In order to provide a heat exchanger which supplies refrigerating output even when the compressor is switched off, the conducting members (102) are penetrated by one or more storage members (114) in which a storage medium is contained.

Abstract: The invention relates to a plate-type heat exchanger having a plate block comprising partition plates which delimit flow channel layers between the plates. According to the invention, the partition plates have a solid or folded edge, which projects out of the plane of at least one main side of the partition plates at the edge side, along closed-edge regions which are spaced apart from one another in the peripheral direction by means of intervening open-edge regions. In the plate block, this solid or folded edge is joined in a fluid-tight manner to the opposite edge region of an adjoining partition plate and functions as a lateral boundary for the associated flow channel layer. Such heat exchangers may be used, for example, in automobiles and reactors of fuel cell systems.

Abstract: The invention relates to an air-conditioner having a heat exchanger, such as an evaporator, for example, with a reservoir for a cold storage medium.

Abstract: A stabilized protein preparation is described which contains no antithrombin III and is protected against loss of activity during pasteurization by the addition of stabilizers which comprise one or more saccharides as a mixture with more than 0.5 mol/l of one or more amino acids chosen from the group arginine, lysine, histidine, phenylalanine, tryptophan, tyrosine, aspartic acid and its salts or glutamic acid and its salts. Glycine and/or glutamine can also be additionally added to each of these amino acids. A process for the viral inactivation or viral depletion of a protein preparation of this type which contains the abovementioned stabilizers and is subjected to pasteurization or viral depletion by filtration, centrifugation or treatment with detergents or bactericidal or virucidal agents is also described.

Abstract: The invention provides a charge air cooler, especially for motor vehicles, having a finned-tube block. The finned-tube block includes flat tubes through which charge air can flow and at least one fin member attached to the flat tubes. At least one fin member includes rows of webs and web crosspieces, the rows offset relative to each other by a predetermined distance. At least one web and/or one web crosspiece possesses at least one vortex generator.

Abstract: An axial-flow fan (1) is arranged on a viscous coupling (4). Fin-like stabilizers (5) are provided in the region of the blade roots, that is to say in the hub region, and these fin-like stabilizers (5) segregate the hub flow and the blade flow. In addition, a radial blade element (6) can be provided and are assigned in each case to these stabilizers and can be integrated with the surface of the stabilizer (5) to form a common surface. These special flow-conducting elements can favorably influence the fan flow in its hub region in such a way as to improve the fan output.

Abstract: A process for the preparation in pure form of the protease activating blood clotting factor VII and/or its proenzyme by use of one or more affinity chromatography separation processes and/or fractional precipitation is described, in which the affinity chromatography separation process used is adsorption on

Abstract: The invention relates to a method of refrigerant level monitoring in a refrigerant circuit of an air-conditioning or heat-pump system having a compressor and a refrigerant which may, depending on the operating point, be operated in the supercritical range. The method includes standstill level monitoring with the compressor switched off and/or in-operation level monitoring with the compressor switched on. In the case of in-operation level monitoring, the refrigerant overheat (dTü) at the evaporator is registered and, in the event of excessive overheat, it is concluded that there is underfilling. At a standstill, the pressure and temperature of the refrigerant are registered, and it is concluded that there is an improper refrigerant filling level if the pressure (pKM) lies below a minimum pressure value (pmin) or the temperature (TKM) lies above a maximum saturation temperature value (TS) with the pressure being outside a predefinable intended pressure range ([pu,po]).

Abstract: The invention relates to a serpentine heat exchanger having a first serpentine tube block (12a) comprising one or more adjacent first serpentine tube sections with parallel through-flow and a second serpentine tube block (12b) disposed behind the first and comprising one or more adjacent second serpentine tube sections with parallel through-flow. According to the invention, at least one of the second serpentine tube sections is connected in series for flow purposes via a diversion section (10, 11) to a first serpentine tube section lying adjacent thereto.

Abstract: The invention relates to a vehicle cooling system (1) for a temperature-raising device (4), especially a drive battery or fuel cell, preferably for an electric or hybrid vehicle. The system has a coolant (7) that cools the device (4) with the involvement of an air-conditioning system (8) that serves for air-conditioning of the vehicle passenger compartment. It is preferred that the coolant (7) be a liquid coolant, which is carried in a cooling circuit (2) and for cooling of the liquid to be thermally integrated into the refrigeration circuit (3) of the air-conditioning system. The invention further relates to a method for cooling a temperature-raising vehicle device.

Abstract: The invention relates to an air-conditioner having a heat exchanger, such as an evaporator, for example, with a reservoir for a cold storage medium.

Abstract: A description is given of a module carrier for various diverse heat exchangers for a motor vehicle engine, which comprises a supporting frame, to which the coolant/air cooler and at least one air-conditioning condenser is fitted. The supporting frame comprises a lower part with a crossmember 2 as base and two side parts 3, 4 projecting vertically therefrom, to define upwardly open compartments 6, 7, 6′, 7′ in the lower part for the insertion of at least the coolant/air cooler and the air-conditioning condenser 9. These upwardly open compartments are closed off by an upper support 5, which interconnects the free ends of the side parts 3, 4 to form the supporting frame and which secures the inserted heat exchangers 8, 9 in their positions.

Abstract: The invention relates to a heat exchanger, particularly of cross-current design, through which at least two separate media can flow. It comprises plates which are stacked on one another and which are spaced apart from one another in some areas and are in contact with one another in other areas, so that flow paths are formed between respectively adjacent plates in a heat exchange region. The plates have apertures adjacent to the heat exchange region, and the plates are spaced apart from one another by means of shaped-out portions of the plates. Areas succeeding one another about the circumference of the plates have apertures, and these areas are alternately shaped out in opposite directions from the plane of the plates.

Abstract: Disclosed is a heating and/or air-conditioning system for a vehicle and a method for adjusting a recirculating air fraction of the inlet air delivered to a passenger compartment of a vehicle in order to avoid exceeding a predetermined limit value of at least one air parameter, in particular the carbon dioxide fraction and/or the humidity in the passenger compartment air. The method provides that one or more secondary parameters be obtained and analyzed for indirect determination of the air parameter, and that the recirculating air fraction be adjusted as a function of the analysis.

Abstract: A process for the preparation of a pure form of protein, wherein the protein is protease activating blood clotting factor VII, the proenzyme for the protease, or a mixture of both the-protease and the proenzyme, is described. The protein is obtained from biological fluids or through genetic engineering and is isolated by anion- and/or cation-exchange chromatography at a pH below the isoelectric point of the protein to be isolated, or by a combination of anion- or cation-exchange chromatography with a chromatography process and/or fractional precipitation at pH between 2.5 and 9.0.

Abstract: A process for the preparation in pure form of the protease activating blood clotting factor VII and/or its proenzyme by the use of a chromatography separation processes and/or fractional precipitation is described. The process used may include adsorption on calcium phosphate/hydroxyapatite, a hydrophobic matrix, a chelate matrix, a matrix on which heparin or a substance related to heparin, such as heparin sulfate or dextran sulfate, is immobilized, or a matrix that is coated with an immobilized monoclonal or polyclonal antibody directed against the protein to be isolated, or F(ab) or F(ab)2 fragments of antibodies directed against the protein to be isolated. A pharmaceutical preparation and a reagent are described which contain the said protease and/or its proenzyme.

Abstract: The device is used to cool a vehicle appliance, in particular a battery or a fuel cell, by means of a coolant. It has a plurality of identically designed cooling elements, through which coolant can flow, which can be brought into bearing contact to cool at least one component of the vehicle appliance. It includes a first cooling-element side and a second cooling-element side which is on the opposite side from the first cooling-element side. The cooling-element sides have connection openings, which form inlet and outlet openings for the coolant and are in communication with the interior space of the cooling element. In this arrangement, it is provided for the first and second cooling-element sides each to have at least two connection openings.