Patents Assigned to Beigene, Ltd.
-
Publication number: 20240150361Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.Type: ApplicationFiled: January 11, 2024Publication date: May 9, 2024Applicant: BeiGene, Ltd.Inventors: Jing LI, Haibo ZHAO, Zhiwei WANG
-
Publication number: 20240096462Abstract: Systems and methods are disclosed for reducing redundancy in medical database management. An example system may include an application program interface communicatively linked to a user interface associated with each of: a plurality of hospital information systems, a plurality of source devices associated with each of the plurality of hospital information systems, and a plurality of electronic data management systems. The system may further include a mapping module configured to map lexical tokens between patient-specific data forms used by each of the system components. An example method may performed by a computing device having one or more processors may include receiving, from the source devices, patient-specific health data; generating updates to patient-specific electronic health records (EHR) for patients; generating patient-specific electronic data capture (EDC) data associated with the patients, and updating electronic data management systems with the patient-specific EDC data.Type: ApplicationFiled: November 30, 2023Publication date: March 21, 2024Applicant: BEIGENE, LTD.Inventors: Geoffrey KIM, Bobby Y. REDDY, Joel Choi PARK, Rajuli LALL
-
Patent number: 11905294Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.Type: GrantFiled: November 23, 2021Date of Patent: February 20, 2024Assignee: BeiGene, Ltd.Inventors: Jing Li, Haibo Zhao, Zhiwei Wang
-
Patent number: 11875885Abstract: Systems and methods are disclosed for reducing redundancy in medical database management. An example system may include an application program interface communicatively linked to a user interface associated with each of: a plurality of hospital information systems, a plurality of source devices associated with each of the plurality of hospital information systems, and a plurality of electronic data management systems. The system may further include a mapping module configured to map lexical tokens between patient-specific data forms used by each of the system components. An example method may performed by a computing device having one or more processors may include receiving, from the source devices, patient-specific health data; generating updates to patient-specific electronic health records (EHR) for patients; generating patient-specific electronic data capture (EDC) data associated with the patients, and updating electronic data management systems with the patient-specific EDC data.Type: GrantFiled: March 28, 2023Date of Patent: January 16, 2024Assignee: BEIGENE, LTD.Inventors: Geoffrey Kim, Bobby Y. Reddy, Joel Choi Park, Rajuli Lall
-
Patent number: 11725012Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.Type: GrantFiled: July 8, 2021Date of Patent: August 15, 2023Assignee: BEIGENE, LTD.Inventors: Jing Li, Haibo Zhao, Zhiwei Wang
-
Patent number: 11636930Abstract: Systems and methods are disclosed for reducing redundancy in medical database management. An example system may include an application program interface communicatively linked to a user interface associated with each of: a plurality of hospital information systems, a plurality of source devices associated with each of the plurality of hospital information systems, and a plurality of electronic data management systems. The system may further include a mapping module configured to map lexical tokens between patient-specific data forms used by each of the system components. An example method may performed by a computing device having one or more processors may include receiving, from the source devices, patient-specific health data; generating updates to patient-specific electronic health records (EHR) for patients; generating patient-specific electronic data capture (EDC) data associated with the patients, and updating electronic data management systems with the patient-specific EDC data.Type: GrantFiled: May 31, 2022Date of Patent: April 25, 2023Assignee: BeiGene, Ltd.Inventors: Geoffrey Kim, Bobby Y. Reddy, Joel Choi Park, Rajuli Lail
-
Patent number: 11597768Abstract: Disclosed herein is method for the prevention, delay of progression or treatment of hepatocellular carcinoma in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of an anti-PD-1 antibody, which is an antibody or a fragment antigen binding thereof, specifically binding to human PD-1.Type: GrantFiled: June 26, 2018Date of Patent: March 7, 2023Assignee: BEIGENE, LTD.Inventors: Lai Wang, Kang Li, Qinzhou Qi, Jeannie Hou, Zhong Wu
-
Patent number: 11555038Abstract: The present invention relates to a crystalline form of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide (Compound 1) for inhibiting Btk, methods of preparation thereof and pharmaceutical compositions, and use of the crystalline form above in the treatment of a disease, or in the manufacturing of a medicament for the treatment of a disease, such as an allergic disease, an autoimmune disease, an inflammatory disease, and a cancer.Type: GrantFiled: January 25, 2018Date of Patent: January 17, 2023Assignee: BEIGENE, LTD.Inventors: Yunhang Guo, Desheng Yu, Zhiwei Wang
-
Patent number: 11512132Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) ligand (PD-L1) and inhibit PD-L1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD-L1-mediated functions.Type: GrantFiled: December 5, 2019Date of Patent: November 29, 2022Assignee: BEIGENE, LTD.Inventors: Kang Li, Jing Song, Tong Zhang, Yucheng Li, Zhiying Ren, Yanshen Kang
-
Patent number: 11472811Abstract: Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as an A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as an A2A receptor antagonist.Type: GrantFiled: April 8, 2019Date of Patent: October 18, 2022Assignee: BEIGENE, LTD.Inventors: Guoliang Zhang, Changyou Zhou
-
Patent number: 11472788Abstract: Disclosed herein are novel benzoimidazoles and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain novel benzoimidazoles that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.Type: GrantFiled: November 24, 2018Date of Patent: October 18, 2022Assignee: BEIGENE, LTD.Inventors: Hexiang Wang, Yunhang Guo, Zhiwei Wang, Changyou Zhou
-
Patent number: 11420968Abstract: Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.Type: GrantFiled: April 29, 2019Date of Patent: August 23, 2022Assignee: BEIGENE, LTD.Inventors: Yunhang Guo, Hai Xue, Zhiwei Wang, Hanzi Sun
-
Patent number: 11393566Abstract: Systems and methods are disclosed for reducing redundancy in medical database management. An example system may include an application program interface communicatively linked to a user interface associated with each of: a plurality of hospital information systems, a plurality of source devices associated with each of the plurality of hospital information systems, and a plurality of electronic data management systems. The system may further include a mapping module configured to map lexical tokens between patient-specific data forms used by each of the system components. An example method may performed by a computing device having one or more processors may include receiving, from the source devices, patient-specific health data; generating updates to patient-specific electronic health records (EHR) for patients; generating patient-specific electronic data capture (EDC) data associated with the patients, and updating electronic data management systems with the patient-specific EDC data.Type: GrantFiled: July 13, 2021Date of Patent: July 19, 2022Assignee: BEIGENE, LTD.Inventors: Geoffrey Kim, Bobby Y. Reddy, Joel Choi Park, Rajuli Lall
-
Patent number: 11377449Abstract: Disclosed herein is a tri-substituted phenyl Btk inhibitors with improved dual selectivity, a method and a composition for inhibiting Btk and treating disease associated with undesirable Btk activity (Btk-related diseases).Type: GrantFiled: August 12, 2018Date of Patent: July 5, 2022Assignee: BEIGENE, LTD.Inventors: Zhiwei Wang, Yunhang Guo, Desheng Yu
-
Patent number: 11220506Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.Type: GrantFiled: September 7, 2018Date of Patent: January 11, 2022Assignee: BEIGENE, LTD.Inventors: Jing Li, Haibo Zhao, Zhiwei Wang
-
Patent number: 11214616Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.Type: GrantFiled: December 29, 2018Date of Patent: January 4, 2022Assignee: BEIGENE, LTD.Inventors: Tong Zhang, Liu Xue, Qi Liu, Min Wei, Kang Li
-
Patent number: 11203637Abstract: Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders that may be modulated by Tim-3-mediated functions.Type: GrantFiled: August 25, 2017Date of Patent: December 21, 2021Assignee: BEIGENE, LTD.Inventors: Tong Zhang, Liu Xue, Qi Liu, Hao Peng, Min Wei, Kang Li
-
Patent number: 11202782Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.Type: GrantFiled: September 27, 2017Date of Patent: December 21, 2021Assignee: BEIGENE, LTD.Inventors: Lai Wang, Zhiyu Tang, Lusong Luo, Min Wei, Kang Li, Jing Song, Tong Zhang, Hexiang Wang, Bo Ren, Changyou Zhou
-
Patent number: 11136323Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.Type: GrantFiled: December 7, 2017Date of Patent: October 5, 2021Assignee: BEIGENE, LTD.Inventors: Jing Li, Haibo Zhao, Zhiwei Wang
-
Patent number: 10899763Abstract: Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.Type: GrantFiled: February 27, 2018Date of Patent: January 26, 2021Assignee: BEIGENE, LTD.Inventors: Hexiang Wang, Xianzhao Kuang, Changyou Zhou