Patents Assigned to Beijing Cotimes Biotech Co., Ltd.
  • Blood markers for diagnosing epithelium derived cancers and monoclonal antibodies thereof
    Patent number: 9840551
    Abstract: The present invention provides uses of cytokeratins as markers for diagnosing epithelium derived cancers. The present invention provides cancer-related epitopes of cytokeratins and monoclonal antibodies which specifically recognize the epitopes. The present invention also provides methods for the early screen, diagnosis or prognosis of epithelium derived cancers in subjects, methods for the evaluation of therapeutic effect of related medicaments or therapies, and kits for accomplishing the methods.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: December 12, 2017
    Assignee: Beijing Cotimes Biotech Co. Ltd.
    Inventors: Enyun Shen, Yang Song, Shiqi Ren
  • HER3 antibodies and uses thereof
    Patent number: 9637543
    Abstract: Provided herein are antibodies specific for HER3. Also provided are methods of treating cancer in a subject comprising administering an effective amount of the antibodies described herein to the subject.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: May 2, 2017
    Assignees: THE UAB RESEARCH FOUNDATION, BEIJING COTIMES BIOTECH CO., LTD.
    Inventors: Tong Zhou, Donald J. Buchsbaum, Enyun Shen, Xian Chen
  • Blood markers for diagnosing epithelium derived cancers and monoclonal antibodies thereof
    Patent number: 9255142
    Abstract: The present invention provides uses of cytokeratins as markers for diagnosing epithelium derived cancers. The present invention provides cancer-related epitopes of cytokeratins and monoclonal antibodies which specifically recognize the epitopes. The present invention also provides methods for the early screen, diagnosis or prognosis of epithelium derived cancers in subjects, methods for the evaluation of therapeutic effect of related medicaments or therapies, and kits for accomplishing the methods.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: February 9, 2016
    Assignee: BEIJING COTIMES BIOTECH CO., LTD.
    Inventors: Enyun Shen, Yang Song, Shiqi Ren
  • Gelsolin binding agent compositions and uses of same
    Patent number: 8367356
    Abstract: The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination, to detect a gelsolin polypeptide (a.k.a., the target polypeptide) in a test sample as well as to purify native gelsolin proteins. Gelsolin binding agents are also useful to diagnose, a gelsolin related medical condition in subjects in need thereof. Kits to detect gelsolin in biological samples are provided by the present invention.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: February 5, 2013
    Assignee: Beijing Cotimes Biotech Co., Ltd.
    Inventors: Enyun Shen, Zheng Yu, Min Zhou, Fei Guo