Abstract: Provided are an anaerobic ammoxidation synergistic nitrogen removal process device of municipal sewage main and side streams and an application method thereof, comprising a municipal sewage raw water tank (1), a biological reaction pool (2), a secondary sedimentation pool (3), a sludge digestion solution raw water tank (4) and a sludge digestion solution AOB strengthening pool (5); wherein, the municipal sewage raw water tank (1) is connected with a water inlet valve (2.2) of the biological reaction pool (2) through a water inlet pump (2.1) of the biological reaction pool (2); the biological reaction pool (2) is connected with the secondary sedimentation pool (3) through a secondary sedimentation pool connection pipe (3.3); the sludge digestion solution raw water tank (4) is connected with a water outlet valve (4.1) of the sludge digestion solution raw water tank (4) through a water inlet pump (4.