Abstract: A probiotics and prebiotics compound preparation and a processing method thereof are provided. The processing method includes the following processing steps: (1) before production, disinfecting hands of personnel, equipment and tools with alcohol at the concentration of 72 percent; (2) respectively drying stachyose, fructo-oligosaccharide, galactooligosaccharide, isomaltooligosaccharide, lactobacillus rhamnosus HN001 and bifidobacterium lactis; (3) mixing 25 to 35 parts of the stachyose, 15 to 25 parts of the fructo-oligosaccharide, 35 to 45 parts of the galactooligosaccharide, 5 to 15 parts of the isomaltooligosaccharide and 0.05 to 0.1 part of caffeine; (4) pasteurizing the mixed saccharide; and (5) respectively adding the lactobacillus rhamnosus HN001 and the bifidobacterium lactis Bi-07 into the mixed saccharide according to a ratio of 3×108 CFU/g. The compound preparation prepared by adopting the method may effectively complete intestinal floras, thereby relieving a burden of allergic dermatitis.