Abstract: The present invention provides a novel use of fibroblast growth factor 2 (FGF-2), i.e., a use of FGF-2 in preparation of medicine. The uses of the medicine are the following (a) and/or (b) and/or (c): (a) the prevention and/or treatment of lung injury; (b) the prevention and/or treatment of influenza; (c) the prevention and/or treatment of diseases caused by influenza viruses.
Type:
Grant
Filed:
August 9, 2013
Date of Patent:
December 3, 2019
Assignee:
BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY
Inventors:
Xiliang Wang, Chengyu Jiang, Penghui Yang, Xin Liu, Yueqiang Duan, Li Xing, Chengcai Lai
Abstract: The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2?O-methyltransferase.
Type:
Application
Filed:
September 23, 2013
Publication date:
August 20, 2015
Applicants:
Agency for Science, Technology and Research, Novartis AG, Beijing Institute of Microbiology and Epidemiology