Abstract: The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.

Abstract: The present invention relates to an active targeted water-solubility macromolecule polymer, conjugate with interferon and pharmaceutical composition comprising the conjugate. The targeted agent includes, for example, glucose, galatose and the like, as well as their derivates. The conjugate of the present invention is well in water-solubility and have long physiological cycle half-life period, and have specific recognition to pathology organize, improved and increased medication effect of interferon to Hepatitis B, Hepatitis C etc. infectivity sickness and cancer, infect complication etc.

Abstract: The present invention discloses conjugates of polyethylene glycol and flavone or flavonoid drugs. The conjugates are formed by attaching PEG to the flavone derivatives such as puerarin, daidzein, baicalein and baicalin to improve their water solubility and circulation half-lives in the body. Because PEG is non-toxic and non-immunogenic, PEG conjugated drug molecules will have better therapeutic effects and convenience in administration.